An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity
Pre-clinical cell culture models capturing the heterogeneity of childhood kidney tumours are limited. Here, the authors establish and characterise an organoid biobank of tumour and matched normal organoid cultures from over 50 children with different subtypes of kidney cancer.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/06e35408aaed4de9ae4266eeecb8d988 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:06e35408aaed4de9ae4266eeecb8d988 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:06e35408aaed4de9ae4266eeecb8d9882021-12-02T14:41:13ZAn organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity10.1038/s41467-020-15155-62041-1723https://doaj.org/article/06e35408aaed4de9ae4266eeecb8d9882020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15155-6https://doaj.org/toc/2041-1723Pre-clinical cell culture models capturing the heterogeneity of childhood kidney tumours are limited. Here, the authors establish and characterise an organoid biobank of tumour and matched normal organoid cultures from over 50 children with different subtypes of kidney cancer.Camilla CalandriniFrans SchutgensRurika OkaThanasis MargaritisTito CandelliLuka MathijsenCarola AmmerlaanRavian L. van IneveldSepide DerakhshanSanne de HaanEmmy DolmanPhilip LijnzaadLars CustersHarry BegthelHindrik H. D. KerstensLindy L. VisserMaarten RookmaakerMarianne VerhaarGodelieve A. M. TytgatPatrick KemmerenRonald R. de KrijgerReem Al-SaadiKathy Pritchard-JonesMarcel KoolAnne C. RiosMarry M. van den Heuvel-EibrinkJan J. MolenaarRuben van BoxtelFrank C. P. HolstegeHans CleversJarno DrostNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Camilla Calandrini Frans Schutgens Rurika Oka Thanasis Margaritis Tito Candelli Luka Mathijsen Carola Ammerlaan Ravian L. van Ineveld Sepide Derakhshan Sanne de Haan Emmy Dolman Philip Lijnzaad Lars Custers Harry Begthel Hindrik H. D. Kerstens Lindy L. Visser Maarten Rookmaaker Marianne Verhaar Godelieve A. M. Tytgat Patrick Kemmeren Ronald R. de Krijger Reem Al-Saadi Kathy Pritchard-Jones Marcel Kool Anne C. Rios Marry M. van den Heuvel-Eibrink Jan J. Molenaar Ruben van Boxtel Frank C. P. Holstege Hans Clevers Jarno Drost An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity |
| description |
Pre-clinical cell culture models capturing the heterogeneity of childhood kidney tumours are limited. Here, the authors establish and characterise an organoid biobank of tumour and matched normal organoid cultures from over 50 children with different subtypes of kidney cancer. |
| format |
article |
| author |
Camilla Calandrini Frans Schutgens Rurika Oka Thanasis Margaritis Tito Candelli Luka Mathijsen Carola Ammerlaan Ravian L. van Ineveld Sepide Derakhshan Sanne de Haan Emmy Dolman Philip Lijnzaad Lars Custers Harry Begthel Hindrik H. D. Kerstens Lindy L. Visser Maarten Rookmaaker Marianne Verhaar Godelieve A. M. Tytgat Patrick Kemmeren Ronald R. de Krijger Reem Al-Saadi Kathy Pritchard-Jones Marcel Kool Anne C. Rios Marry M. van den Heuvel-Eibrink Jan J. Molenaar Ruben van Boxtel Frank C. P. Holstege Hans Clevers Jarno Drost |
| author_facet |
Camilla Calandrini Frans Schutgens Rurika Oka Thanasis Margaritis Tito Candelli Luka Mathijsen Carola Ammerlaan Ravian L. van Ineveld Sepide Derakhshan Sanne de Haan Emmy Dolman Philip Lijnzaad Lars Custers Harry Begthel Hindrik H. D. Kerstens Lindy L. Visser Maarten Rookmaaker Marianne Verhaar Godelieve A. M. Tytgat Patrick Kemmeren Ronald R. de Krijger Reem Al-Saadi Kathy Pritchard-Jones Marcel Kool Anne C. Rios Marry M. van den Heuvel-Eibrink Jan J. Molenaar Ruben van Boxtel Frank C. P. Holstege Hans Clevers Jarno Drost |
| author_sort |
Camilla Calandrini |
| title |
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity |
| title_short |
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity |
| title_full |
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity |
| title_fullStr |
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity |
| title_full_unstemmed |
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity |
| title_sort |
organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/06e35408aaed4de9ae4266eeecb8d988 |
| work_keys_str_mv |
AT camillacalandrini anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT fransschutgens anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT rurikaoka anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT thanasismargaritis anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT titocandelli anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT lukamathijsen anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT carolaammerlaan anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT ravianlvanineveld anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT sepidederakhshan anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT sannedehaan anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT emmydolman anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT philiplijnzaad anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT larscusters anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT harrybegthel anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT hindrikhdkerstens anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT lindylvisser anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT maartenrookmaaker anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT marianneverhaar anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT godelieveamtytgat anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT patrickkemmeren anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT ronaldrdekrijger anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT reemalsaadi anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT kathypritchardjones anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT marcelkool anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT annecrios anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT marrymvandenheuveleibrink anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT janjmolenaar anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT rubenvanboxtel anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT frankcpholstege anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT hansclevers anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT jarnodrost anorganoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT camillacalandrini organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT fransschutgens organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT rurikaoka organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT thanasismargaritis organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT titocandelli organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT lukamathijsen organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT carolaammerlaan organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT ravianlvanineveld organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT sepidederakhshan organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT sannedehaan organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT emmydolman organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT philiplijnzaad organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT larscusters organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT harrybegthel organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT hindrikhdkerstens organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT lindylvisser organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT maartenrookmaaker organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT marianneverhaar organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT godelieveamtytgat organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT patrickkemmeren organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT ronaldrdekrijger organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT reemalsaadi organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT kathypritchardjones organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT marcelkool organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT annecrios organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT marrymvandenheuveleibrink organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT janjmolenaar organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT rubenvanboxtel organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT frankcpholstege organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT hansclevers organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity AT jarnodrost organoidbiobankforchildhoodkidneycancersthatcapturesdiseaseandtissueheterogeneity |
| _version_ |
1718389971447971840 |