A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response

Abstract Dendritic Cells (DCs) recognize infectious non-self molecules and engage the adaptive immune system thereby initiating long lasting, antigen-specific responses. As such, the ability to activate DCs is considered a key tool to enhance the efficacy and quality of vaccination. Here we report a...

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Autores principales:	Emiliano Manzo, Adele Cutignano, Dario Pagano, Carmela Gallo, Giusi Barra, Genoveffa Nuzzo, Clementina Sansone, Adrianna Ianora, Konrad Urbanek, Daniela Fenoglio, Francesca Ferrera, Cinzia Bernardi, Alessia Parodi, Giuseppe Pasquale, Antonio Leonardi, Gilberto Filaci, Raffaele De Palma, Angelo Fontana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06e4ee2dc6c9413e9898903048ad0136
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spelling	oai:doaj.org-article:06e4ee2dc6c9413e9898903048ad01362021-12-02T16:05:59ZA new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response10.1038/s41598-017-05969-82045-2322https://doaj.org/article/06e4ee2dc6c9413e9898903048ad01362017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05969-8https://doaj.org/toc/2045-2322Abstract Dendritic Cells (DCs) recognize infectious non-self molecules and engage the adaptive immune system thereby initiating long lasting, antigen-specific responses. As such, the ability to activate DCs is considered a key tool to enhance the efficacy and quality of vaccination. Here we report a novel immunomodulatory sulfolipid named β-SQDG18 that prototypes a class of natural-derived glycolipids able to prime human DCs by a TLR2/TLR4-independent mechanism and trigger an efficient immune response in vivo. β-SQDG18 induces maturation of DC with the upregulation of MHC II molecules and co-stimulatory proteins (CD83, CD86), as well as pro-inflammatory cytokines (IL-12 and INF-γ). Mice immunized with OVA associated to β-SQDG18 (1:500) produced a titer of anti-OVA Ig comparable to traditional adjuvants. In an experimental model of melanoma, vaccination of C57BL/6 mice with β-SQDG18-adjuvanted hgp10 peptide elicited a protective response with a reduction in tumour growth and increase in survival.Emiliano ManzoAdele CutignanoDario PaganoCarmela GalloGiusi BarraGenoveffa NuzzoClementina SansoneAdrianna IanoraKonrad UrbanekDaniela FenoglioFrancesca FerreraCinzia BernardiAlessia ParodiGiuseppe PasqualeAntonio LeonardiGilberto FilaciRaffaele De PalmaAngelo FontanaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emiliano Manzo Adele Cutignano Dario Pagano Carmela Gallo Giusi Barra Genoveffa Nuzzo Clementina Sansone Adrianna Ianora Konrad Urbanek Daniela Fenoglio Francesca Ferrera Cinzia Bernardi Alessia Parodi Giuseppe Pasquale Antonio Leonardi Gilberto Filaci Raffaele De Palma Angelo Fontana A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response
description	Abstract Dendritic Cells (DCs) recognize infectious non-self molecules and engage the adaptive immune system thereby initiating long lasting, antigen-specific responses. As such, the ability to activate DCs is considered a key tool to enhance the efficacy and quality of vaccination. Here we report a novel immunomodulatory sulfolipid named β-SQDG18 that prototypes a class of natural-derived glycolipids able to prime human DCs by a TLR2/TLR4-independent mechanism and trigger an efficient immune response in vivo. β-SQDG18 induces maturation of DC with the upregulation of MHC II molecules and co-stimulatory proteins (CD83, CD86), as well as pro-inflammatory cytokines (IL-12 and INF-γ). Mice immunized with OVA associated to β-SQDG18 (1:500) produced a titer of anti-OVA Ig comparable to traditional adjuvants. In an experimental model of melanoma, vaccination of C57BL/6 mice with β-SQDG18-adjuvanted hgp10 peptide elicited a protective response with a reduction in tumour growth and increase in survival.
format	article
author	Emiliano Manzo Adele Cutignano Dario Pagano Carmela Gallo Giusi Barra Genoveffa Nuzzo Clementina Sansone Adrianna Ianora Konrad Urbanek Daniela Fenoglio Francesca Ferrera Cinzia Bernardi Alessia Parodi Giuseppe Pasquale Antonio Leonardi Gilberto Filaci Raffaele De Palma Angelo Fontana
author_facet	Emiliano Manzo Adele Cutignano Dario Pagano Carmela Gallo Giusi Barra Genoveffa Nuzzo Clementina Sansone Adrianna Ianora Konrad Urbanek Daniela Fenoglio Francesca Ferrera Cinzia Bernardi Alessia Parodi Giuseppe Pasquale Antonio Leonardi Gilberto Filaci Raffaele De Palma Angelo Fontana
author_sort	Emiliano Manzo
title	A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response
title_short	A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response
title_full	A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response
title_fullStr	A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response
title_full_unstemmed	A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response
title_sort	new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/06e4ee2dc6c9413e9898903048ad0136
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A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response

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