Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sensitivity to Aurora kinase inhibitors.

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Autores principales:	Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
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spelling	oai:doaj.org-article:06e749d7f425413a87006cc1366f2c042021-12-02T16:28:01ZIntegrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer10.1038/s41467-021-24841-y2041-1723https://doaj.org/article/06e749d7f425413a87006cc1366f2c042021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24841-yhttps://doaj.org/toc/2041-1723RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sensitivity to Aurora kinase inhibitors.Athea VichasAmanda K. RileyNaomi T. NkinsiShriya KamlapurkarPhoebe C. R. ParrishApril LoFujiko DukeJennifer ChenIris FungJacqueline WatsonMatthew ReesAustin M. GabelJames D. ThomasRobert K. BradleyJohn K. LeeEmily M. HatchMarina K. BaineNatasha RekhtmanMarc LadanyiFederica PiccioniAlice H. BergerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Athea Vichas Amanda K. Riley Naomi T. Nkinsi Shriya Kamlapurkar Phoebe C. R. Parrish April Lo Fujiko Duke Jennifer Chen Iris Fung Jacqueline Watson Matthew Rees Austin M. Gabel James D. Thomas Robert K. Bradley John K. Lee Emily M. Hatch Marina K. Baine Natasha Rekhtman Marc Ladanyi Federica Piccioni Alice H. Berger Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
description	RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sensitivity to Aurora kinase inhibitors.
format	article
author	Athea Vichas Amanda K. Riley Naomi T. Nkinsi Shriya Kamlapurkar Phoebe C. R. Parrish April Lo Fujiko Duke Jennifer Chen Iris Fung Jacqueline Watson Matthew Rees Austin M. Gabel James D. Thomas Robert K. Bradley John K. Lee Emily M. Hatch Marina K. Baine Natasha Rekhtman Marc Ladanyi Federica Piccioni Alice H. Berger
author_facet	Athea Vichas Amanda K. Riley Naomi T. Nkinsi Shriya Kamlapurkar Phoebe C. R. Parrish April Lo Fujiko Duke Jennifer Chen Iris Fung Jacqueline Watson Matthew Rees Austin M. Gabel James D. Thomas Robert K. Bradley John K. Lee Emily M. Hatch Marina K. Baine Natasha Rekhtman Marc Ladanyi Federica Piccioni Alice H. Berger
author_sort	Athea Vichas
title	Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
title_short	Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
title_full	Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
title_fullStr	Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
title_full_unstemmed	Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
title_sort	integrative oncogene-dependency mapping identifies rit1 vulnerabilities and synergies in lung cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
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Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

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