ATR inhibition enables complete tumour regression in ALK-driven NB mouse models

Effective therapeutic options are still needed in neuroblastoma treatment. Here, the authors, through a comprehensive proteomics analysis, identify ATR as a potential therapeutic target of neuroblastoma and demonstrate the efficacy of the ATR inhibitor BAY1895344 in combination with the ALK tyrosine...

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Autores principales:	Joanna Szydzik, Dan E. Lind, Badrul Arefin, Yeshwant Kurhe, Ganesh Umapathy, Joachim Tetteh Siaw, Arne Claeys, Jonatan L. Gabre, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/06e9a92a8a164615981fa91b32e6d409
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spelling	oai:doaj.org-article:06e9a92a8a164615981fa91b32e6d4092021-11-28T12:31:22ZATR inhibition enables complete tumour regression in ALK-driven NB mouse models10.1038/s41467-021-27057-22041-1723https://doaj.org/article/06e9a92a8a164615981fa91b32e6d4092021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27057-2https://doaj.org/toc/2041-1723Effective therapeutic options are still needed in neuroblastoma treatment. Here, the authors, through a comprehensive proteomics analysis, identify ATR as a potential therapeutic target of neuroblastoma and demonstrate the efficacy of the ATR inhibitor BAY1895344 in combination with the ALK tyrosine kinase inhibitor lorlatinib.Joanna SzydzikDan E. LindBadrul ArefinYeshwant KurheGanesh UmapathyJoachim Tetteh SiawArne ClaeysJonatan L. GabreJimmy Van den EyndenBengt HallbergRuth H. PalmerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joanna Szydzik Dan E. Lind Badrul Arefin Yeshwant Kurhe Ganesh Umapathy Joachim Tetteh Siaw Arne Claeys Jonatan L. Gabre Jimmy Van den Eynden Bengt Hallberg Ruth H. Palmer ATR inhibition enables complete tumour regression in ALK-driven NB mouse models
description	Effective therapeutic options are still needed in neuroblastoma treatment. Here, the authors, through a comprehensive proteomics analysis, identify ATR as a potential therapeutic target of neuroblastoma and demonstrate the efficacy of the ATR inhibitor BAY1895344 in combination with the ALK tyrosine kinase inhibitor lorlatinib.
format	article
author	Joanna Szydzik Dan E. Lind Badrul Arefin Yeshwant Kurhe Ganesh Umapathy Joachim Tetteh Siaw Arne Claeys Jonatan L. Gabre Jimmy Van den Eynden Bengt Hallberg Ruth H. Palmer
author_facet	Joanna Szydzik Dan E. Lind Badrul Arefin Yeshwant Kurhe Ganesh Umapathy Joachim Tetteh Siaw Arne Claeys Jonatan L. Gabre Jimmy Van den Eynden Bengt Hallberg Ruth H. Palmer
author_sort	Joanna Szydzik
title	ATR inhibition enables complete tumour regression in ALK-driven NB mouse models
title_short	ATR inhibition enables complete tumour regression in ALK-driven NB mouse models
title_full	ATR inhibition enables complete tumour regression in ALK-driven NB mouse models
title_fullStr	ATR inhibition enables complete tumour regression in ALK-driven NB mouse models
title_full_unstemmed	ATR inhibition enables complete tumour regression in ALK-driven NB mouse models
title_sort	atr inhibition enables complete tumour regression in alk-driven nb mouse models
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06e9a92a8a164615981fa91b32e6d409
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ATR inhibition enables complete tumour regression in ALK-driven NB mouse models

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