Fourier analysis of corneal Scheimpflug imaging: clinical use in keratoconus

AIM: To evaluate the clinical use of Fourier analysis of videokeratography data in the diagnosis and follow-up of keratoconus (KC). METHODS: We conducted a chart review of consecutive patients presented to our cornea clinic. A team of two experienced cornea specialists divided the patients into thre...

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Autores principales:	Dorukcan Akincioglu, Gokhan Ozge, Onder Ayyildiz, Gokcen Gokce, Umut Karaca, Fatih Mehmet Mutlu
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	fourier keratoconus scheimpflug imaging tomography topography Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/06eb58d410ad45e88240614f694aab51
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spelling	oai:doaj.org-article:06eb58d410ad45e88240614f694aab512021-11-26T04:02:12ZFourier analysis of corneal Scheimpflug imaging: clinical use in keratoconus2222-39592227-489810.18240/ijo.2021.12.23https://doaj.org/article/06eb58d410ad45e88240614f694aab512021-12-01T00:00:00Zhttp://ies.ijo.cn/en_publish/2021/12/20211223.pdfhttps://doaj.org/toc/2222-3959https://doaj.org/toc/2227-4898AIM: To evaluate the clinical use of Fourier analysis of videokeratography data in the diagnosis and follow-up of keratoconus (KC). METHODS: We conducted a chart review of consecutive patients presented to our cornea clinic. A team of two experienced cornea specialists divided the patients into three groups: normal cornea, forme fruste KC (FFKC), and clinical KC. The exclusion criteria were a history of previous ocular surgery, any accompanying corneal pathology other than KC, high myopia (>6.00 diopters), amblyopia, pregnancy, breastfeeding, or any current autoimmune disease. The data of Fourier series harmonic analysis were evaluated for their diagnostic capacity using the receiver operating characteristic (ROC) curve. A binary logistic regression analysis was also conducted to construct a diagnostic model. A total of 259 eyes showed progression in the clinical KC group and underwent a combination of accelerated corneal collagen cross-linking and topography-guided customized treatment with an excimer laser. RESULTS: The study included 1262 eyes (618 normal, 530 KC, and 114 FFKC) of 1262 patients. We observed that maximum decentration (MaxDec) was almost as good as maximum keratometry (Kmax) in detecting progressive KC. The area under the curve (AUC) was 0.95 for KC [95% confidence interval (CI): 0.93-0.96] and 0.84 for FFKC (95%CI: 0.79-0.88). Higher predictive accuracy was obtained using a model combining the spherical component, MaxDec, irregularity, and regular astigmatism in the center of the cornea (AUC: 0.97; sensitivity: 89%, and specificity: 96%). CONCLUSION: Decentration, Kmax, and posterior radii of curvatures from a 3.0-mm optical zone centered on the thinnest point of the cornea provide the highest accuracy with low reproducibility of Kmax.Dorukcan AkinciogluGokhan OzgeOnder AyyildizGokcen GokceUmut KaracaFatih Mehmet MutluPress of International Journal of Ophthalmology (IJO PRESS)articlefourierkeratoconusscheimpflug imagingtomographytopographyOphthalmologyRE1-994ENInternational Journal of Ophthalmology, Vol 14, Iss 12, Pp 1963-1969 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fourier keratoconus scheimpflug imaging tomography topography Ophthalmology RE1-994
spellingShingle	fourier keratoconus scheimpflug imaging tomography topography Ophthalmology RE1-994 Dorukcan Akincioglu Gokhan Ozge Onder Ayyildiz Gokcen Gokce Umut Karaca Fatih Mehmet Mutlu Fourier analysis of corneal Scheimpflug imaging: clinical use in keratoconus
description	AIM: To evaluate the clinical use of Fourier analysis of videokeratography data in the diagnosis and follow-up of keratoconus (KC). METHODS: We conducted a chart review of consecutive patients presented to our cornea clinic. A team of two experienced cornea specialists divided the patients into three groups: normal cornea, forme fruste KC (FFKC), and clinical KC. The exclusion criteria were a history of previous ocular surgery, any accompanying corneal pathology other than KC, high myopia (>6.00 diopters), amblyopia, pregnancy, breastfeeding, or any current autoimmune disease. The data of Fourier series harmonic analysis were evaluated for their diagnostic capacity using the receiver operating characteristic (ROC) curve. A binary logistic regression analysis was also conducted to construct a diagnostic model. A total of 259 eyes showed progression in the clinical KC group and underwent a combination of accelerated corneal collagen cross-linking and topography-guided customized treatment with an excimer laser. RESULTS: The study included 1262 eyes (618 normal, 530 KC, and 114 FFKC) of 1262 patients. We observed that maximum decentration (MaxDec) was almost as good as maximum keratometry (Kmax) in detecting progressive KC. The area under the curve (AUC) was 0.95 for KC [95% confidence interval (CI): 0.93-0.96] and 0.84 for FFKC (95%CI: 0.79-0.88). Higher predictive accuracy was obtained using a model combining the spherical component, MaxDec, irregularity, and regular astigmatism in the center of the cornea (AUC: 0.97; sensitivity: 89%, and specificity: 96%). CONCLUSION: Decentration, Kmax, and posterior radii of curvatures from a 3.0-mm optical zone centered on the thinnest point of the cornea provide the highest accuracy with low reproducibility of Kmax.
format	article
author	Dorukcan Akincioglu Gokhan Ozge Onder Ayyildiz Gokcen Gokce Umut Karaca Fatih Mehmet Mutlu
author_facet	Dorukcan Akincioglu Gokhan Ozge Onder Ayyildiz Gokcen Gokce Umut Karaca Fatih Mehmet Mutlu
author_sort	Dorukcan Akincioglu
title	Fourier analysis of corneal Scheimpflug imaging: clinical use in keratoconus
title_short	Fourier analysis of corneal Scheimpflug imaging: clinical use in keratoconus
title_full	Fourier analysis of corneal Scheimpflug imaging: clinical use in keratoconus
title_fullStr	Fourier analysis of corneal Scheimpflug imaging: clinical use in keratoconus
title_full_unstemmed	Fourier analysis of corneal Scheimpflug imaging: clinical use in keratoconus
title_sort	fourier analysis of corneal scheimpflug imaging: clinical use in keratoconus
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/06eb58d410ad45e88240614f694aab51
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Fourier analysis of corneal Scheimpflug imaging: clinical use in keratoconus

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