INTERRELATIONSHIP BETWEEN EFFICIENCY OF CANCER TREATMENT AND STATE OF IMMUNE SYSTEM IN PATIENTS WITH LARYNGEAL AND HYPOPHARYNGEAL CANCER

Abstract. We have studied possible interrelationships between immune system state and efficiency of neoadjuvant chemoradiotherapy in patients with cancer of larynx and hypopharynx. The neoadjuvant treatment consisted of 2 courses of paclitaxel (175 mg/m2), carboplatin (AUC-6 in 3-4 weeks), followed...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M. N. Stakheyeva, E. L. Choinzonov, S. Yu. Chizhevskaya, V. A. Bychkov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immune system head and neck cancer antitumor treatment efficiency Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/06ec0286b2de4157948308994b1c65dd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:06ec0286b2de4157948308994b1c65dd
record_format	dspace
spelling	oai:doaj.org-article:06ec0286b2de4157948308994b1c65dd2021-11-18T08:03:43ZINTERRELATIONSHIP BETWEEN EFFICIENCY OF CANCER TREATMENT AND STATE OF IMMUNE SYSTEM IN PATIENTS WITH LARYNGEAL AND HYPOPHARYNGEAL CANCER1563-06252313-741X10.15789/1563-0625-2013-6-553-562https://doaj.org/article/06ec0286b2de4157948308994b1c65dd2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/674https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We have studied possible interrelationships between immune system state and efficiency of neoadjuvant chemoradiotherapy in patients with cancer of larynx and hypopharynx. The neoadjuvant treatment consisted of 2 courses of paclitaxel (175 mg/m2), carboplatin (AUC-6 in 3-4 weeks), followed by radiation therapy at a multifraction dose schedule (1.2 Gy 2 times daily in 4 h, total cumulated dose was estimated as isoeffective dose of 40 Gy). A better response to chemotherapy by paclitaxel and carboplatin in the patients with cancer of larynx and hypopharynx had been associated with higher percentage of CD56+ cells and IgM levels in peripheral blood, as measured before starting cancer treatment. After completing the neoadjuvant chemo- and radiotherapy, we noted an increase in total lymphocyte counts, CD4+, CD8+, CD56+ cell numbers and IgG levels in the patients with pronounced response to chemotherapy, thus suggesting some induction of immune response in cancer patients during cytostatic therapy. These data presume a relationship between the state of immune system in the patients with head-and-neck cancer, and their response to neoadjuvant chemo- and radiotherapy. On the basis of these findings, one may suggest that immunological mechanisms make take an important part in promotion of antitumor effects produced by standard cancer treatment.M. N. StakheyevaE. L. ChoinzonovS. Yu. ChizhevskayaV. A. BychkovSPb RAACIarticleimmune systemhead and neck cancerantitumor treatmentefficiencyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 6, Pp 553-562 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immune system head and neck cancer antitumor treatment efficiency Immunologic diseases. Allergy RC581-607
spellingShingle	immune system head and neck cancer antitumor treatment efficiency Immunologic diseases. Allergy RC581-607 M. N. Stakheyeva E. L. Choinzonov S. Yu. Chizhevskaya V. A. Bychkov INTERRELATIONSHIP BETWEEN EFFICIENCY OF CANCER TREATMENT AND STATE OF IMMUNE SYSTEM IN PATIENTS WITH LARYNGEAL AND HYPOPHARYNGEAL CANCER
description	Abstract. We have studied possible interrelationships between immune system state and efficiency of neoadjuvant chemoradiotherapy in patients with cancer of larynx and hypopharynx. The neoadjuvant treatment consisted of 2 courses of paclitaxel (175 mg/m2), carboplatin (AUC-6 in 3-4 weeks), followed by radiation therapy at a multifraction dose schedule (1.2 Gy 2 times daily in 4 h, total cumulated dose was estimated as isoeffective dose of 40 Gy). A better response to chemotherapy by paclitaxel and carboplatin in the patients with cancer of larynx and hypopharynx had been associated with higher percentage of CD56+ cells and IgM levels in peripheral blood, as measured before starting cancer treatment. After completing the neoadjuvant chemo- and radiotherapy, we noted an increase in total lymphocyte counts, CD4+, CD8+, CD56+ cell numbers and IgG levels in the patients with pronounced response to chemotherapy, thus suggesting some induction of immune response in cancer patients during cytostatic therapy. These data presume a relationship between the state of immune system in the patients with head-and-neck cancer, and their response to neoadjuvant chemo- and radiotherapy. On the basis of these findings, one may suggest that immunological mechanisms make take an important part in promotion of antitumor effects produced by standard cancer treatment.
format	article
author	M. N. Stakheyeva E. L. Choinzonov S. Yu. Chizhevskaya V. A. Bychkov
author_facet	M. N. Stakheyeva E. L. Choinzonov S. Yu. Chizhevskaya V. A. Bychkov
author_sort	M. N. Stakheyeva
title	INTERRELATIONSHIP BETWEEN EFFICIENCY OF CANCER TREATMENT AND STATE OF IMMUNE SYSTEM IN PATIENTS WITH LARYNGEAL AND HYPOPHARYNGEAL CANCER
title_short	INTERRELATIONSHIP BETWEEN EFFICIENCY OF CANCER TREATMENT AND STATE OF IMMUNE SYSTEM IN PATIENTS WITH LARYNGEAL AND HYPOPHARYNGEAL CANCER
title_full	INTERRELATIONSHIP BETWEEN EFFICIENCY OF CANCER TREATMENT AND STATE OF IMMUNE SYSTEM IN PATIENTS WITH LARYNGEAL AND HYPOPHARYNGEAL CANCER
title_fullStr	INTERRELATIONSHIP BETWEEN EFFICIENCY OF CANCER TREATMENT AND STATE OF IMMUNE SYSTEM IN PATIENTS WITH LARYNGEAL AND HYPOPHARYNGEAL CANCER
title_full_unstemmed	INTERRELATIONSHIP BETWEEN EFFICIENCY OF CANCER TREATMENT AND STATE OF IMMUNE SYSTEM IN PATIENTS WITH LARYNGEAL AND HYPOPHARYNGEAL CANCER
title_sort	interrelationship between efficiency of cancer treatment and state of immune system in patients with laryngeal and hypopharyngeal cancer
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/06ec0286b2de4157948308994b1c65dd
work_keys_str_mv	AT mnstakheyeva interrelationshipbetweenefficiencyofcancertreatmentandstateofimmunesysteminpatientswithlaryngealandhypopharyngealcancer AT elchoinzonov interrelationshipbetweenefficiencyofcancertreatmentandstateofimmunesysteminpatientswithlaryngealandhypopharyngealcancer AT syuchizhevskaya interrelationshipbetweenefficiencyofcancertreatmentandstateofimmunesysteminpatientswithlaryngealandhypopharyngealcancer AT vabychkov interrelationshipbetweenefficiencyofcancertreatmentandstateofimmunesysteminpatientswithlaryngealandhypopharyngealcancer
_version_	1718422461518708736

INTERRELATIONSHIP BETWEEN EFFICIENCY OF CANCER TREATMENT AND STATE OF IMMUNE SYSTEM IN PATIENTS WITH LARYNGEAL AND HYPOPHARYNGEAL CANCER

Ejemplares similares