Sam68 promotes hepatic gluconeogenesis via CRTC2

Sam68 promotes hepatic gluconeogenesis via CRTC2

Hepatic gluconeogenesis is important for glucose homeostasis and a therapeutic target for type 2 diabetes. Here, the authors show that the RNA-binding adaptor protein Sam68 promotes the expression level of gluconeogenic genes and increases blood glucose levels by stabilizing the transcriptional coac...

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Autores principales: Aijun Qiao, Junlan Zhou, Shiyue Xu, Wenxia Ma, Chan Boriboun, Teayoun Kim, Baolong Yan, Jianxin Deng, Liu Yang, Eric Zhang, Yuhua Song, Yongchao C. Ma, Stephane Richard, Chunxiang Zhang, Hongyu Qiu, Kirk M. Habegger, Jianyi Zhang, Gangjian Qin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/06ee0683d6c7406d8c7218d61e9eae37
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Sumario:Hepatic gluconeogenesis is important for glucose homeostasis and a therapeutic target for type 2 diabetes. Here, the authors show that the RNA-binding adaptor protein Sam68 promotes the expression level of gluconeogenic genes and increases blood glucose levels by stabilizing the transcriptional coactivator CRTC2, while hepatic Sam68 deletion alleviates hyperglycemia in mice.

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