Sam68 promotes hepatic gluconeogenesis via CRTC2

Hepatic gluconeogenesis is important for glucose homeostasis and a therapeutic target for type 2 diabetes. Here, the authors show that the RNA-binding adaptor protein Sam68 promotes the expression level of gluconeogenic genes and increases blood glucose levels by stabilizing the transcriptional coac...

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Autores principales:	Aijun Qiao, Junlan Zhou, Shiyue Xu, Wenxia Ma, Chan Boriboun, Teayoun Kim, Baolong Yan, Jianxin Deng, Liu Yang, Eric Zhang, Yuhua Song, Yongchao C. Ma, Stephane Richard, Chunxiang Zhang, Hongyu Qiu, Kirk M. Habegger, Jianyi Zhang, Gangjian Qin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/06ee0683d6c7406d8c7218d61e9eae37
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spelling	oai:doaj.org-article:06ee0683d6c7406d8c7218d61e9eae372021-12-02T17:38:25ZSam68 promotes hepatic gluconeogenesis via CRTC210.1038/s41467-021-23624-92041-1723https://doaj.org/article/06ee0683d6c7406d8c7218d61e9eae372021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23624-9https://doaj.org/toc/2041-1723Hepatic gluconeogenesis is important for glucose homeostasis and a therapeutic target for type 2 diabetes. Here, the authors show that the RNA-binding adaptor protein Sam68 promotes the expression level of gluconeogenic genes and increases blood glucose levels by stabilizing the transcriptional coactivator CRTC2, while hepatic Sam68 deletion alleviates hyperglycemia in mice.Aijun QiaoJunlan ZhouShiyue XuWenxia MaChan BoribounTeayoun KimBaolong YanJianxin DengLiu YangEric ZhangYuhua SongYongchao C. MaStephane RichardChunxiang ZhangHongyu QiuKirk M. HabeggerJianyi ZhangGangjian QinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aijun Qiao Junlan Zhou Shiyue Xu Wenxia Ma Chan Boriboun Teayoun Kim Baolong Yan Jianxin Deng Liu Yang Eric Zhang Yuhua Song Yongchao C. Ma Stephane Richard Chunxiang Zhang Hongyu Qiu Kirk M. Habegger Jianyi Zhang Gangjian Qin Sam68 promotes hepatic gluconeogenesis via CRTC2
description	Hepatic gluconeogenesis is important for glucose homeostasis and a therapeutic target for type 2 diabetes. Here, the authors show that the RNA-binding adaptor protein Sam68 promotes the expression level of gluconeogenic genes and increases blood glucose levels by stabilizing the transcriptional coactivator CRTC2, while hepatic Sam68 deletion alleviates hyperglycemia in mice.
format	article
author	Aijun Qiao Junlan Zhou Shiyue Xu Wenxia Ma Chan Boriboun Teayoun Kim Baolong Yan Jianxin Deng Liu Yang Eric Zhang Yuhua Song Yongchao C. Ma Stephane Richard Chunxiang Zhang Hongyu Qiu Kirk M. Habegger Jianyi Zhang Gangjian Qin
author_facet	Aijun Qiao Junlan Zhou Shiyue Xu Wenxia Ma Chan Boriboun Teayoun Kim Baolong Yan Jianxin Deng Liu Yang Eric Zhang Yuhua Song Yongchao C. Ma Stephane Richard Chunxiang Zhang Hongyu Qiu Kirk M. Habegger Jianyi Zhang Gangjian Qin
author_sort	Aijun Qiao
title	Sam68 promotes hepatic gluconeogenesis via CRTC2
title_short	Sam68 promotes hepatic gluconeogenesis via CRTC2
title_full	Sam68 promotes hepatic gluconeogenesis via CRTC2
title_fullStr	Sam68 promotes hepatic gluconeogenesis via CRTC2
title_full_unstemmed	Sam68 promotes hepatic gluconeogenesis via CRTC2
title_sort	sam68 promotes hepatic gluconeogenesis via crtc2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06ee0683d6c7406d8c7218d61e9eae37
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Sam68 promotes hepatic gluconeogenesis via CRTC2

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