Artificially controlled degradable nanoparticles for contrast switch MRI and programmed cancer therapy

Tianyang Yun,1 Yuxin Liu,2 Shaoqiong Yi,1 Qi Jia,2 Yang Liu,1 Jing Zhou21Department of Thoracic Surgery, Chinese People’s Liberation Army General Hospital, Beijing 100853, People’s Republic of China; 2Department of Chemistry, Capital Normal University, Beijing 100048, People&...

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Autores principales:	Yun T, Liu Y, Yi S, Jia Q, Zhou J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	photothermal degradable controllable drug release synergistic therapy magnetic resonance imaging Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/06f20d974b024222aa228e04d978f376
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spelling	oai:doaj.org-article:06f20d974b024222aa228e04d978f3762021-12-02T09:59:50ZArtificially controlled degradable nanoparticles for contrast switch MRI and programmed cancer therapy1178-2013https://doaj.org/article/06f20d974b024222aa228e04d978f3762018-10-01T00:00:00Zhttps://www.dovepress.com/artificially-controlled-degradable-nanoparticles-for-contrast-switch-m-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Tianyang Yun,1 Yuxin Liu,2 Shaoqiong Yi,1 Qi Jia,2 Yang Liu,1 Jing Zhou21Department of Thoracic Surgery, Chinese People’s Liberation Army General Hospital, Beijing 100853, People’s Republic of China; 2Department of Chemistry, Capital Normal University, Beijing 100048, People’s Republic of China Background: Utilizing the permeability enhancement and irreversible biomolecule denaturation caused by hyperthermia, photothermal-chemo synergistic therapy has shown great potential in clinical cancer treatment.Purpose: The objective of this study was to provide a novel controlled drug release method to improve the efficiency of photothermal-chemo synergistic therapy.Patients and methods: HCT116 tumor-bearing mice were selected as modal for the study of cancer theranostics efficiency. The T2 to T1 magnetic resonance imaging contrast switch was studied in vivo. Analyses of the tumor growth of mice were carried out to evaluate the tumor therapy efficiency.Results: we developed novel artificially controlled degradable Co3O4 nanoparticles and explored their potential in drug delivery/release. In the presence of ascorbic acid (AA), the designed nanomaterials can be degraded via a redox process and hence release the loaded drugs. Importantly, the AA, in the lack of l-gulonolactone oxidase, cannot be synthesized in the body of typical mammal including human, which suggested that the degradation process can be controlled artificially. Moreover, the obtained nanoparticles have outstanding photothermal conversion efficiency and their degradation can also result in an magnetic resonance imaging contrast enhancement switch from T2 to T1, which benefits the cancer theranostics.Conclusion: Our results illustrated that the artificially controlled degradable nanoparticles can serve as an alternative candidate for controllable drug release as well as a platform for highly efficient photothermal-chemo synergistic cancer theranostics.Keywords: photothermal, degradable, controllable drug release, synergistic therapy, MRIYun TLiu YYi SJia QLiu YZhou JDove Medical Pressarticlephotothermaldegradablecontrollable drug releasesynergistic therapymagnetic resonance imagingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 6647-6659 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	photothermal degradable controllable drug release synergistic therapy magnetic resonance imaging Medicine (General) R5-920
spellingShingle	photothermal degradable controllable drug release synergistic therapy magnetic resonance imaging Medicine (General) R5-920 Yun T Liu Y Yi S Jia Q Liu Y Zhou J Artificially controlled degradable nanoparticles for contrast switch MRI and programmed cancer therapy
description	Tianyang Yun,1 Yuxin Liu,2 Shaoqiong Yi,1 Qi Jia,2 Yang Liu,1 Jing Zhou21Department of Thoracic Surgery, Chinese People’s Liberation Army General Hospital, Beijing 100853, People’s Republic of China; 2Department of Chemistry, Capital Normal University, Beijing 100048, People’s Republic of China Background: Utilizing the permeability enhancement and irreversible biomolecule denaturation caused by hyperthermia, photothermal-chemo synergistic therapy has shown great potential in clinical cancer treatment.Purpose: The objective of this study was to provide a novel controlled drug release method to improve the efficiency of photothermal-chemo synergistic therapy.Patients and methods: HCT116 tumor-bearing mice were selected as modal for the study of cancer theranostics efficiency. The T2 to T1 magnetic resonance imaging contrast switch was studied in vivo. Analyses of the tumor growth of mice were carried out to evaluate the tumor therapy efficiency.Results: we developed novel artificially controlled degradable Co3O4 nanoparticles and explored their potential in drug delivery/release. In the presence of ascorbic acid (AA), the designed nanomaterials can be degraded via a redox process and hence release the loaded drugs. Importantly, the AA, in the lack of l-gulonolactone oxidase, cannot be synthesized in the body of typical mammal including human, which suggested that the degradation process can be controlled artificially. Moreover, the obtained nanoparticles have outstanding photothermal conversion efficiency and their degradation can also result in an magnetic resonance imaging contrast enhancement switch from T2 to T1, which benefits the cancer theranostics.Conclusion: Our results illustrated that the artificially controlled degradable nanoparticles can serve as an alternative candidate for controllable drug release as well as a platform for highly efficient photothermal-chemo synergistic cancer theranostics.Keywords: photothermal, degradable, controllable drug release, synergistic therapy, MRI
format	article
author	Yun T Liu Y Yi S Jia Q Liu Y Zhou J
author_facet	Yun T Liu Y Yi S Jia Q Liu Y Zhou J
author_sort	Yun T
title	Artificially controlled degradable nanoparticles for contrast switch MRI and programmed cancer therapy
title_short	Artificially controlled degradable nanoparticles for contrast switch MRI and programmed cancer therapy
title_full	Artificially controlled degradable nanoparticles for contrast switch MRI and programmed cancer therapy
title_fullStr	Artificially controlled degradable nanoparticles for contrast switch MRI and programmed cancer therapy
title_full_unstemmed	Artificially controlled degradable nanoparticles for contrast switch MRI and programmed cancer therapy
title_sort	artificially controlled degradable nanoparticles for contrast switch mri and programmed cancer therapy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/06f20d974b024222aa228e04d978f376
work_keys_str_mv	AT yunt artificiallycontrolleddegradablenanoparticlesforcontrastswitchmriandprogrammedcancertherapy AT liuy artificiallycontrolleddegradablenanoparticlesforcontrastswitchmriandprogrammedcancertherapy AT yis artificiallycontrolleddegradablenanoparticlesforcontrastswitchmriandprogrammedcancertherapy AT jiaq artificiallycontrolleddegradablenanoparticlesforcontrastswitchmriandprogrammedcancertherapy AT liuy artificiallycontrolleddegradablenanoparticlesforcontrastswitchmriandprogrammedcancertherapy AT zhouj artificiallycontrolleddegradablenanoparticlesforcontrastswitchmriandprogrammedcancertherapy
_version_	1718397807047475200

Artificially controlled degradable nanoparticles for contrast switch MRI and programmed cancer therapy

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