Effect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents

Aim. To consider homocysteinemia in children and adolescents with diabetes mellitus (DM1) as an independent risk factor of diabetic nephro- and retinopathy (DN and DR). Materials and methods. Twenty nine adolescents (19 girls and 10 boys) with DM1 were examined. DN and DR were diagnosed in conform...

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Autores principales:	Zh V Shutskaya, E B Bashnina, O V Mochkin, T A Dubinina, T Yu Tryasova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	diabetic nephropathy diabetic retinopathy adolescents homocysteinemia Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/06f3b25335e345678047a5617ef2bf14
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spelling	oai:doaj.org-article:06f3b25335e345678047a5617ef2bf142021-11-14T09:00:13ZEffect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents2072-03512072-037810.14341/2072-0351-5423https://doaj.org/article/06f3b25335e345678047a5617ef2bf142009-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5423https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To consider homocysteinemia in children and adolescents with diabetes mellitus (DM1) as an independent risk factor of diabetic nephro- and retinopathy (DN and DR). Materials and methods. Twenty nine adolescents (19 girls and 10 boys) with DM1 were examined. DN and DR were diagnosed in conformity with medical aid standards for DM1patients. Plasma homocysteine level was measured by IEA. Results. Plasma homocysteine level in DN patients was higher (6.4?1.6, n=10) than in DR group (5.3?1.7, n=9) and controls (5.6?1.8, n=10). Patients of all study groups werecomparable in terms of age, DM duration, and HbA1c level. Conclusion. Plasma homocysteine level in DN patients was higher than in DR and control groups. It gives reason to consider this parameter as an independent risk factor alongwith some others in pathogenesis of diabetic microangiopathies (in the first place, nephropathy). Adolescents with DM1 and elevated plasma homocysteine level need additionalcorrection by specific medicines.Zh V ShutskayaE B BashninaO V MochkinT A DubininaT Yu TryasovaEndocrinology Research Centrearticlediabetic nephropathydiabetic retinopathyadolescentshomocysteinemiaNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 1, Pp 52-53 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetic nephropathy diabetic retinopathy adolescents homocysteinemia Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetic nephropathy diabetic retinopathy adolescents homocysteinemia Nutritional diseases. Deficiency diseases RC620-627 Zh V Shutskaya E B Bashnina O V Mochkin T A Dubinina T Yu Tryasova Effect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents
description	Aim. To consider homocysteinemia in children and adolescents with diabetes mellitus (DM1) as an independent risk factor of diabetic nephro- and retinopathy (DN and DR). Materials and methods. Twenty nine adolescents (19 girls and 10 boys) with DM1 were examined. DN and DR were diagnosed in conformity with medical aid standards for DM1patients. Plasma homocysteine level was measured by IEA. Results. Plasma homocysteine level in DN patients was higher (6.4?1.6, n=10) than in DR group (5.3?1.7, n=9) and controls (5.6?1.8, n=10). Patients of all study groups werecomparable in terms of age, DM duration, and HbA1c level. Conclusion. Plasma homocysteine level in DN patients was higher than in DR and control groups. It gives reason to consider this parameter as an independent risk factor alongwith some others in pathogenesis of diabetic microangiopathies (in the first place, nephropathy). Adolescents with DM1 and elevated plasma homocysteine level need additionalcorrection by specific medicines.
format	article
author	Zh V Shutskaya E B Bashnina O V Mochkin T A Dubinina T Yu Tryasova
author_facet	Zh V Shutskaya E B Bashnina O V Mochkin T A Dubinina T Yu Tryasova
author_sort	Zh V Shutskaya
title	Effect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents
title_short	Effect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents
title_full	Effect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents
title_fullStr	Effect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents
title_full_unstemmed	Effect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents
title_sort	effect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/06f3b25335e345678047a5617ef2bf14
work_keys_str_mv	AT zhvshutskaya effectofhomocysteinemiaonthedevelopmentofdiabeticnephroandretinopathyinadolescents AT ebbashnina effectofhomocysteinemiaonthedevelopmentofdiabeticnephroandretinopathyinadolescents AT ovmochkin effectofhomocysteinemiaonthedevelopmentofdiabeticnephroandretinopathyinadolescents AT tadubinina effectofhomocysteinemiaonthedevelopmentofdiabeticnephroandretinopathyinadolescents AT tyutryasova effectofhomocysteinemiaonthedevelopmentofdiabeticnephroandretinopathyinadolescents
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Effect of homocysteinemia on the development of diabetic nephro- and retinopathy in adolescents

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