Acute toxicity and chromosomal aberration toxicity of insect wax and its policosanol

An acute toxicity test in Sprague Dawley (SD) rats and a chromosomal aberration toxicity test in Chinese hamster lung (CHL) fibroblasts were conducted to promote the application of insect wax and its policosanol. Results of oral acute toxicity test showed that the LD50 values of insect wax and its p...

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Autores principales:	Jinju Ma, Kun Li, Wenwen Zhang, Liyi Ma, Juan Xu, Lanxiang Liu, Xiaoming Chen, Hong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Insect wax Policosanol from insect wax Acute toxicity Chromosomal aberration Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/06f3f9fa768046af85350c458b1fd791
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spelling	oai:doaj.org-article:06f3f9fa768046af85350c458b1fd7912021-11-28T04:32:01ZAcute toxicity and chromosomal aberration toxicity of insect wax and its policosanol2213-453010.1016/j.fshw.2021.11.013https://doaj.org/article/06f3f9fa768046af85350c458b1fd7912022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213453021001099https://doaj.org/toc/2213-4530An acute toxicity test in Sprague Dawley (SD) rats and a chromosomal aberration toxicity test in Chinese hamster lung (CHL) fibroblasts were conducted to promote the application of insect wax and its policosanol. Results of oral acute toxicity test showed that the LD50 values of insect wax and its policosanol were higher than 5000 mg/kg. The rats showed no obvious toxic symptoms and survived, suggesting that these substances were not toxic. The chromosomal aberration rates of the CHL cells incubated with insect wax for 3–6 h under metabolic activation conditions and for 3–6 h and 24 h under non-metabolic activation conditions were lower than 5%. No significant difference was found compared with the negative control group. Also, no significant difference in chromosomal aberration rates was found between each dose group of policosanol under metabolic or non-metabolic activation conditions and the negative control group. Therefore, the chromosomal aberration rates of CHL cells treated with insect wax and its policosanol were negative regardless of metabolic activation conditions. These results indicate the absence of acute toxicity and potential chromosomal aberration in the tested dose range of insect wax and its policosanol.Jinju MaKun LiWenwen ZhangLiyi MaJuan XuLanxiang LiuXiaoming ChenHong ZhangKeAi Communications Co., Ltd.articleInsect waxPolicosanol from insect waxAcute toxicityChromosomal aberrationNutrition. Foods and food supplyTX341-641ENFood Science and Human Wellness, Vol 11, Iss 2, Pp 356-365 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Insect wax Policosanol from insect wax Acute toxicity Chromosomal aberration Nutrition. Foods and food supply TX341-641
spellingShingle	Insect wax Policosanol from insect wax Acute toxicity Chromosomal aberration Nutrition. Foods and food supply TX341-641 Jinju Ma Kun Li Wenwen Zhang Liyi Ma Juan Xu Lanxiang Liu Xiaoming Chen Hong Zhang Acute toxicity and chromosomal aberration toxicity of insect wax and its policosanol
description	An acute toxicity test in Sprague Dawley (SD) rats and a chromosomal aberration toxicity test in Chinese hamster lung (CHL) fibroblasts were conducted to promote the application of insect wax and its policosanol. Results of oral acute toxicity test showed that the LD50 values of insect wax and its policosanol were higher than 5000 mg/kg. The rats showed no obvious toxic symptoms and survived, suggesting that these substances were not toxic. The chromosomal aberration rates of the CHL cells incubated with insect wax for 3–6 h under metabolic activation conditions and for 3–6 h and 24 h under non-metabolic activation conditions were lower than 5%. No significant difference was found compared with the negative control group. Also, no significant difference in chromosomal aberration rates was found between each dose group of policosanol under metabolic or non-metabolic activation conditions and the negative control group. Therefore, the chromosomal aberration rates of CHL cells treated with insect wax and its policosanol were negative regardless of metabolic activation conditions. These results indicate the absence of acute toxicity and potential chromosomal aberration in the tested dose range of insect wax and its policosanol.
format	article
author	Jinju Ma Kun Li Wenwen Zhang Liyi Ma Juan Xu Lanxiang Liu Xiaoming Chen Hong Zhang
author_facet	Jinju Ma Kun Li Wenwen Zhang Liyi Ma Juan Xu Lanxiang Liu Xiaoming Chen Hong Zhang
author_sort	Jinju Ma
title	Acute toxicity and chromosomal aberration toxicity of insect wax and its policosanol
title_short	Acute toxicity and chromosomal aberration toxicity of insect wax and its policosanol
title_full	Acute toxicity and chromosomal aberration toxicity of insect wax and its policosanol
title_fullStr	Acute toxicity and chromosomal aberration toxicity of insect wax and its policosanol
title_full_unstemmed	Acute toxicity and chromosomal aberration toxicity of insect wax and its policosanol
title_sort	acute toxicity and chromosomal aberration toxicity of insect wax and its policosanol
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/06f3f9fa768046af85350c458b1fd791
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Acute toxicity and chromosomal aberration toxicity of insect wax and its policosanol

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