Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil

Abstract Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relat...

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Autores principales:	Geovani de Oliveira Ribeiro, Antonio Charlys da Costa, Danielle Elise Gill, Edcelha Soares D’Athaide Ribeiro, Marlisson Octavio da S. Rego, Fred Julio Costa Monteiro, Fabiola Villanova, Juliana Silva Nogueira, Adriana Yurika Maeda, Renato Pereira de Souza, Roozbeh Tahmasebi, Vanessa S. Morais, Ramendra Pati Pandey, V. Samuel Raj, Sirle Abdo Salloum Scandar, Fernanda Gisele da Silva Vasami, Leandro Guaraglia D’Agostino, Paulo César Maiorka, Xutao Deng, Maurício Lacerda Nogueira, Ester Cerdeira Sabino, Eric Delwart, Élcio Leal, Mariana Sequetin Cunha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/06f8db6d04d248c3b15bf9c18c25c0a8
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spelling	oai:doaj.org-article:06f8db6d04d248c3b15bf9c18c25c0a82021-12-02T15:53:59ZGuapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil10.1038/s41598-021-83879-62045-2322https://doaj.org/article/06f8db6d04d248c3b15bf9c18c25c0a82021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83879-6https://doaj.org/toc/2045-2322Abstract Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying principles of mammalian pathogenicity. Here we describe the genetic characterization of a novel putative dISFV, termed Guapiaçu virus (GUAPV). Distinct strains of GUAPV were isolated from pools of Aedes terrens and Aedes scapularis mosquitoes. Additionally, we also detected viral GUAPV RNA in a plasma sample of an individual febrile from the Amazon region (North of Brazil). Although GUAPV did not replicate in tested mammalian cells, 3′UTR secondary structures duplication and codon usage index were similar to pathogenic flavivirus.Geovani de Oliveira RibeiroAntonio Charlys da CostaDanielle Elise GillEdcelha Soares D’Athaide RibeiroMarlisson Octavio da S. RegoFred Julio Costa MonteiroFabiola VillanovaJuliana Silva NogueiraAdriana Yurika MaedaRenato Pereira de SouzaRoozbeh TahmasebiVanessa S. MoraisRamendra Pati PandeyV. Samuel RajSirle Abdo Salloum ScandarFernanda Gisele da Silva VasamiLeandro Guaraglia D’AgostinoPaulo César MaiorkaXutao DengMaurício Lacerda NogueiraEster Cerdeira SabinoEric DelwartÉlcio LealMariana Sequetin CunhaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Geovani de Oliveira Ribeiro Antonio Charlys da Costa Danielle Elise Gill Edcelha Soares D’Athaide Ribeiro Marlisson Octavio da S. Rego Fred Julio Costa Monteiro Fabiola Villanova Juliana Silva Nogueira Adriana Yurika Maeda Renato Pereira de Souza Roozbeh Tahmasebi Vanessa S. Morais Ramendra Pati Pandey V. Samuel Raj Sirle Abdo Salloum Scandar Fernanda Gisele da Silva Vasami Leandro Guaraglia D’Agostino Paulo César Maiorka Xutao Deng Maurício Lacerda Nogueira Ester Cerdeira Sabino Eric Delwart Élcio Leal Mariana Sequetin Cunha Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil
description	Abstract Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying principles of mammalian pathogenicity. Here we describe the genetic characterization of a novel putative dISFV, termed Guapiaçu virus (GUAPV). Distinct strains of GUAPV were isolated from pools of Aedes terrens and Aedes scapularis mosquitoes. Additionally, we also detected viral GUAPV RNA in a plasma sample of an individual febrile from the Amazon region (North of Brazil). Although GUAPV did not replicate in tested mammalian cells, 3′UTR secondary structures duplication and codon usage index were similar to pathogenic flavivirus.
format	article
author	Geovani de Oliveira Ribeiro Antonio Charlys da Costa Danielle Elise Gill Edcelha Soares D’Athaide Ribeiro Marlisson Octavio da S. Rego Fred Julio Costa Monteiro Fabiola Villanova Juliana Silva Nogueira Adriana Yurika Maeda Renato Pereira de Souza Roozbeh Tahmasebi Vanessa S. Morais Ramendra Pati Pandey V. Samuel Raj Sirle Abdo Salloum Scandar Fernanda Gisele da Silva Vasami Leandro Guaraglia D’Agostino Paulo César Maiorka Xutao Deng Maurício Lacerda Nogueira Ester Cerdeira Sabino Eric Delwart Élcio Leal Mariana Sequetin Cunha
author_facet	Geovani de Oliveira Ribeiro Antonio Charlys da Costa Danielle Elise Gill Edcelha Soares D’Athaide Ribeiro Marlisson Octavio da S. Rego Fred Julio Costa Monteiro Fabiola Villanova Juliana Silva Nogueira Adriana Yurika Maeda Renato Pereira de Souza Roozbeh Tahmasebi Vanessa S. Morais Ramendra Pati Pandey V. Samuel Raj Sirle Abdo Salloum Scandar Fernanda Gisele da Silva Vasami Leandro Guaraglia D’Agostino Paulo César Maiorka Xutao Deng Maurício Lacerda Nogueira Ester Cerdeira Sabino Eric Delwart Élcio Leal Mariana Sequetin Cunha
author_sort	Geovani de Oliveira Ribeiro
title	Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil
title_short	Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil
title_full	Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil
title_fullStr	Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil
title_full_unstemmed	Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil
title_sort	guapiaçu virus, a new insect-specific flavivirus isolated from two species of aedes mosquitoes from brazil
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/06f8db6d04d248c3b15bf9c18c25c0a8
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Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil

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