Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal

Cancer stem cells (CSCs) have key roles in tumor initiation and metastasis. Here, the authors show that the SUMO E1 and global sumoylation levels are high in colorectal CSCs and that depletion of the catalytic subunit of the SUMO E1, SAE2, affects CSCs self-renewal through TRIM21-mediated degradatio...

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Autores principales:	Li Du, Yi-Jia Li, Marwan Fakih, Rebecca L. Wiatrek, Marjun Duldulao, Zhenbin Chen, Peiguo Chu, Julio Garcia-Aguilar, Yuan Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/06fb9b69954d417596dc90173bdd25cb
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spelling	oai:doaj.org-article:06fb9b69954d417596dc90173bdd25cb2021-12-02T16:49:42ZRole of SUMO activating enzyme in cancer stem cell maintenance and self-renewal10.1038/ncomms123262041-1723https://doaj.org/article/06fb9b69954d417596dc90173bdd25cb2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12326https://doaj.org/toc/2041-1723Cancer stem cells (CSCs) have key roles in tumor initiation and metastasis. Here, the authors show that the SUMO E1 and global sumoylation levels are high in colorectal CSCs and that depletion of the catalytic subunit of the SUMO E1, SAE2, affects CSCs self-renewal through TRIM21-mediated degradation of the Oct1, a transcription factor for ALDH.Li DuYi-Jia LiMarwan FakihRebecca L. WiatrekMarjun DuldulaoZhenbin ChenPeiguo ChuJulio Garcia-AguilarYuan ChenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li Du Yi-Jia Li Marwan Fakih Rebecca L. Wiatrek Marjun Duldulao Zhenbin Chen Peiguo Chu Julio Garcia-Aguilar Yuan Chen Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal
description	Cancer stem cells (CSCs) have key roles in tumor initiation and metastasis. Here, the authors show that the SUMO E1 and global sumoylation levels are high in colorectal CSCs and that depletion of the catalytic subunit of the SUMO E1, SAE2, affects CSCs self-renewal through TRIM21-mediated degradation of the Oct1, a transcription factor for ALDH.
format	article
author	Li Du Yi-Jia Li Marwan Fakih Rebecca L. Wiatrek Marjun Duldulao Zhenbin Chen Peiguo Chu Julio Garcia-Aguilar Yuan Chen
author_facet	Li Du Yi-Jia Li Marwan Fakih Rebecca L. Wiatrek Marjun Duldulao Zhenbin Chen Peiguo Chu Julio Garcia-Aguilar Yuan Chen
author_sort	Li Du
title	Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal
title_short	Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal
title_full	Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal
title_fullStr	Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal
title_full_unstemmed	Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal
title_sort	role of sumo activating enzyme in cancer stem cell maintenance and self-renewal
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/06fb9b69954d417596dc90173bdd25cb
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Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal

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