A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study

Background: Statins are the most common drugs used for reducing low-density lipids (LDL). In addition to their lipid-lowering effects, they have well-documented anti-inflammatory actions. The goal of this study was to compare the effects of high dose atorvastatin and rosuvastatin on lipid profiles a...

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Autores principales:	Mahboubeh Darban, Elham Yusefabadi, Majid MirmohammadKhani, Bahram Sohrabi, Bahador Bagheri
Formato:	article
Lenguaje:	EN
Publicado:	Tabriz University of Medical Sciences 2021
Materias:	rosuvastatin atherosclerosis atorvastatin lipid profile hs-crp Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/0700fe16d23d4938a60556a0ae209610
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spelling	oai:doaj.org-article:0700fe16d23d4938a60556a0ae2096102021-11-29T05:53:56ZA Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study2383-288610.34172/PS.2021.5https://doaj.org/article/0700fe16d23d4938a60556a0ae2096102021-12-01T00:00:00Zhttps://ps.tbzmed.ac.ir/PDF/ps-27-568.pdfhttps://doaj.org/toc/2383-2886Background: Statins are the most common drugs used for reducing low-density lipids (LDL). In addition to their lipid-lowering effects, they have well-documented anti-inflammatory actions. The goal of this study was to compare the effects of high dose atorvastatin and rosuvastatin on lipid profiles and high sensitivity C Reactive Protein (hs-CRP) in patients undergoing percutaneous coronary intervention (PCI). Methods: The study was done between October 2017 and September 2018 in Semnan KowsarHospital. In this randomized trial, 69 patients with atherosclerotic coronary artery disease were randomly assigned 1:1 to receive atorvastatin (80 mg daily) or rosuvastatin (40 mg daily) for4 months. Levels of hs-CRP and lipid profiles including cholesterol, triglyceride, low-density lipids (LDL), and high-density lipids (HDL) were measured and compared before and after the treatments. Lipid profiles were measured at baseline, 2 months, and 4 months of the treatment. Results: Sixty patients completed the study. The mean age was 61.1 ± 6.6 years with an excess of males. After 4 months, both drugs could significantly reduce LDL levels, however, the between-group differences were not statistically significant. Rosuvastatin significantly increased HDL levels (p < 0.05). In addition, triglyceride levels had a significant reduction in both groups, yet the differences were not significant. Both drugs caused significant reductions in hs-CRP levels(p < 0.05). Moreover, the effects of treatments were seen in drug naïve patients as well as patients who were on statins prior to the trial. Conclusion: The results indicate that high dose therapies with atorvastatin and rosuvastatin have similar effects on lipid profiles and hs-CRP levels in patients undergoing PCI.Mahboubeh DarbanElham YusefabadiMajid MirmohammadKhaniBahram SohrabiBahador BagheriTabriz University of Medical Sciencesarticlerosuvastatinatherosclerosisatorvastatinlipid profilehs-crpPharmacy and materia medicaRS1-441ENPharmaceutical Sciences, Vol 27, Iss 4, Pp 568-574 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rosuvastatin atherosclerosis atorvastatin lipid profile hs-crp Pharmacy and materia medica RS1-441
spellingShingle	rosuvastatin atherosclerosis atorvastatin lipid profile hs-crp Pharmacy and materia medica RS1-441 Mahboubeh Darban Elham Yusefabadi Majid MirmohammadKhani Bahram Sohrabi Bahador Bagheri A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study
description	Background: Statins are the most common drugs used for reducing low-density lipids (LDL). In addition to their lipid-lowering effects, they have well-documented anti-inflammatory actions. The goal of this study was to compare the effects of high dose atorvastatin and rosuvastatin on lipid profiles and high sensitivity C Reactive Protein (hs-CRP) in patients undergoing percutaneous coronary intervention (PCI). Methods: The study was done between October 2017 and September 2018 in Semnan KowsarHospital. In this randomized trial, 69 patients with atherosclerotic coronary artery disease were randomly assigned 1:1 to receive atorvastatin (80 mg daily) or rosuvastatin (40 mg daily) for4 months. Levels of hs-CRP and lipid profiles including cholesterol, triglyceride, low-density lipids (LDL), and high-density lipids (HDL) were measured and compared before and after the treatments. Lipid profiles were measured at baseline, 2 months, and 4 months of the treatment. Results: Sixty patients completed the study. The mean age was 61.1 ± 6.6 years with an excess of males. After 4 months, both drugs could significantly reduce LDL levels, however, the between-group differences were not statistically significant. Rosuvastatin significantly increased HDL levels (p < 0.05). In addition, triglyceride levels had a significant reduction in both groups, yet the differences were not significant. Both drugs caused significant reductions in hs-CRP levels(p < 0.05). Moreover, the effects of treatments were seen in drug naïve patients as well as patients who were on statins prior to the trial. Conclusion: The results indicate that high dose therapies with atorvastatin and rosuvastatin have similar effects on lipid profiles and hs-CRP levels in patients undergoing PCI.
format	article
author	Mahboubeh Darban Elham Yusefabadi Majid MirmohammadKhani Bahram Sohrabi Bahador Bagheri
author_facet	Mahboubeh Darban Elham Yusefabadi Majid MirmohammadKhani Bahram Sohrabi Bahador Bagheri
author_sort	Mahboubeh Darban
title	A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study
title_short	A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study
title_full	A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study
title_fullStr	A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study
title_full_unstemmed	A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study
title_sort	comparison on effects of high dose rosuvastatin versus high dose atorvastatin on lipid profile and crp level in patients undergoing percutaneous coronary intervention: a randomized study
publisher	Tabriz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/0700fe16d23d4938a60556a0ae209610
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A Comparison on Effects of High Dose Rosuvastatin versus High Dose Atorvastatin on Lipid Profile and CRP Level in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Study

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