Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity

Using a transgenic mouse model that recapitulates abacavir hypersensitivity syndrome, an idiosyncratic adverse drug reaction, Susukida et al show that individual differences in the immune tolerance system affect the susceptibility to idiosyncratic drug toxicity.

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Autores principales:	Takeshi Susukida, Saki Kuwahara, Binbin Song, Akira Kazaoka, Shigeki Aoki, Kousei Ito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0708c2eab29f4f089b35989678191d1e
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spelling	oai:doaj.org-article:0708c2eab29f4f089b35989678191d1e2021-12-02T17:37:39ZRegulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity10.1038/s42003-021-02657-22399-3642https://doaj.org/article/0708c2eab29f4f089b35989678191d1e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02657-2https://doaj.org/toc/2399-3642Using a transgenic mouse model that recapitulates abacavir hypersensitivity syndrome, an idiosyncratic adverse drug reaction, Susukida et al show that individual differences in the immune tolerance system affect the susceptibility to idiosyncratic drug toxicity.Takeshi SusukidaSaki KuwaharaBinbin SongAkira KazaokaShigeki AokiKousei ItoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Takeshi Susukida Saki Kuwahara Binbin Song Akira Kazaoka Shigeki Aoki Kousei Ito Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity
description	Using a transgenic mouse model that recapitulates abacavir hypersensitivity syndrome, an idiosyncratic adverse drug reaction, Susukida et al show that individual differences in the immune tolerance system affect the susceptibility to idiosyncratic drug toxicity.
format	article
author	Takeshi Susukida Saki Kuwahara Binbin Song Akira Kazaoka Shigeki Aoki Kousei Ito
author_facet	Takeshi Susukida Saki Kuwahara Binbin Song Akira Kazaoka Shigeki Aoki Kousei Ito
author_sort	Takeshi Susukida
title	Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity
title_short	Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity
title_full	Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity
title_fullStr	Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity
title_full_unstemmed	Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity
title_sort	regulation of the immune tolerance system determines the susceptibility to hla-mediated abacavir-induced skin toxicity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0708c2eab29f4f089b35989678191d1e
work_keys_str_mv	AT takeshisusukida regulationoftheimmunetolerancesystemdeterminesthesusceptibilitytohlamediatedabacavirinducedskintoxicity AT sakikuwahara regulationoftheimmunetolerancesystemdeterminesthesusceptibilitytohlamediatedabacavirinducedskintoxicity AT binbinsong regulationoftheimmunetolerancesystemdeterminesthesusceptibilitytohlamediatedabacavirinducedskintoxicity AT akirakazaoka regulationoftheimmunetolerancesystemdeterminesthesusceptibilitytohlamediatedabacavirinducedskintoxicity AT shigekiaoki regulationoftheimmunetolerancesystemdeterminesthesusceptibilitytohlamediatedabacavirinducedskintoxicity AT kouseiito regulationoftheimmunetolerancesystemdeterminesthesusceptibilitytohlamediatedabacavirinducedskintoxicity
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Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity

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