Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets

Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus with no specific treatment or vaccine available. Here, the authors develop a DNA vaccine for SFTSV that is protective against lethal challenge in ferrets and show that anti-envelope antibodies are important for...

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Autores principales: Jeong-Eun Kwak, Young-Il Kim, Su-Jin Park, Min-Ah Yu, Hyeok-Il Kwon, Sukyeong Eo, Tae-Shin Kim, Joon Seok, Won-Suk Choi, Ju Hwan Jeong, Hyojin Lee, Youngran Cho, Jin Ah Kwon, Moonsup Jeong, Joel N. Maslow, Yong-Eun Kim, Haili Jeon, Kee K. Kim, Eui-Cheol Shin, Min-Suk Song, Jae U. Jung, Young Ki Choi, Su-Hyung Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/070e15f3b66f4dec8015fa9c64ead744
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Sumario:Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus with no specific treatment or vaccine available. Here, the authors develop a DNA vaccine for SFTSV that is protective against lethal challenge in ferrets and show that anti-envelope antibodies are important for protection.

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