Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus with no specific treatment or vaccine available. Here, the authors develop a DNA vaccine for SFTSV that is protective against lethal challenge in ferrets and show that anti-envelope antibodies are important for...

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Autores principales:	Jeong-Eun Kwak, Young-Il Kim, Su-Jin Park, Min-Ah Yu, Hyeok-Il Kwon, Sukyeong Eo, Tae-Shin Kim, Joon Seok, Won-Suk Choi, Ju Hwan Jeong, Hyojin Lee, Youngran Cho, Jin Ah Kwon, Moonsup Jeong, Joel N. Maslow, Yong-Eun Kim, Haili Jeon, Kee K. Kim, Eui-Cheol Shin, Min-Suk Song, Jae U. Jung, Young Ki Choi, Su-Hyung Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/070e15f3b66f4dec8015fa9c64ead744
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spelling	oai:doaj.org-article:070e15f3b66f4dec8015fa9c64ead7442021-12-02T16:58:13ZDevelopment of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets10.1038/s41467-019-11815-42041-1723https://doaj.org/article/070e15f3b66f4dec8015fa9c64ead7442019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11815-4https://doaj.org/toc/2041-1723Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus with no specific treatment or vaccine available. Here, the authors develop a DNA vaccine for SFTSV that is protective against lethal challenge in ferrets and show that anti-envelope antibodies are important for protection.Jeong-Eun KwakYoung-Il KimSu-Jin ParkMin-Ah YuHyeok-Il KwonSukyeong EoTae-Shin KimJoon SeokWon-Suk ChoiJu Hwan JeongHyojin LeeYoungran ChoJin Ah KwonMoonsup JeongJoel N. MaslowYong-Eun KimHaili JeonKee K. KimEui-Cheol ShinMin-Suk SongJae U. JungYoung Ki ChoiSu-Hyung ParkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeong-Eun Kwak Young-Il Kim Su-Jin Park Min-Ah Yu Hyeok-Il Kwon Sukyeong Eo Tae-Shin Kim Joon Seok Won-Suk Choi Ju Hwan Jeong Hyojin Lee Youngran Cho Jin Ah Kwon Moonsup Jeong Joel N. Maslow Yong-Eun Kim Haili Jeon Kee K. Kim Eui-Cheol Shin Min-Suk Song Jae U. Jung Young Ki Choi Su-Hyung Park Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets
description	Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne virus with no specific treatment or vaccine available. Here, the authors develop a DNA vaccine for SFTSV that is protective against lethal challenge in ferrets and show that anti-envelope antibodies are important for protection.
format	article
author	Jeong-Eun Kwak Young-Il Kim Su-Jin Park Min-Ah Yu Hyeok-Il Kwon Sukyeong Eo Tae-Shin Kim Joon Seok Won-Suk Choi Ju Hwan Jeong Hyojin Lee Youngran Cho Jin Ah Kwon Moonsup Jeong Joel N. Maslow Yong-Eun Kim Haili Jeon Kee K. Kim Eui-Cheol Shin Min-Suk Song Jae U. Jung Young Ki Choi Su-Hyung Park
author_facet	Jeong-Eun Kwak Young-Il Kim Su-Jin Park Min-Ah Yu Hyeok-Il Kwon Sukyeong Eo Tae-Shin Kim Joon Seok Won-Suk Choi Ju Hwan Jeong Hyojin Lee Youngran Cho Jin Ah Kwon Moonsup Jeong Joel N. Maslow Yong-Eun Kim Haili Jeon Kee K. Kim Eui-Cheol Shin Min-Suk Song Jae U. Jung Young Ki Choi Su-Hyung Park
author_sort	Jeong-Eun Kwak
title	Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets
title_short	Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets
title_full	Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets
title_fullStr	Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets
title_full_unstemmed	Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets
title_sort	development of a sftsv dna vaccine that confers complete protection against lethal infection in ferrets
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/070e15f3b66f4dec8015fa9c64ead744
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Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets

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