NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy

Cervical cancer is one of the most prevalent gynaecological malignancies worldwide and is related to human papillomavirus (HPV) infection, viral persistence, progression, and invasion. Therefore, the immune response is linked to HPV status. Natural killer (NK) cells play a central role against virus...

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Autores principales:	Adriana Gutiérrez-Hoya, Isabel Soto-Cruz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cervical cancer NK cells HPV immune system immunotherapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/070e4ddd1d124dc7b1fd5db5b8b6c760
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spelling	oai:doaj.org-article:070e4ddd1d124dc7b1fd5db5b8b6c7602021-11-25T17:11:33ZNK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy10.3390/cells101131042073-4409https://doaj.org/article/070e4ddd1d124dc7b1fd5db5b8b6c7602021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3104https://doaj.org/toc/2073-4409Cervical cancer is one of the most prevalent gynaecological malignancies worldwide and is related to human papillomavirus (HPV) infection, viral persistence, progression, and invasion. Therefore, the immune response is linked to HPV status. Natural killer (NK) cells play a central role against virus-infected cells and tumours through a delicate balance between activating and inhibitory receptors and secretion of cytokines and chemokines. These cells also play a crucial role in tumour immunosurveillance. For these reasons, there is growing interest in harnessing NK cells as an immunotherapy for cervical cancer. These studies are diverse and include many strategies such as transferring activated autologous or allogeneic NK cells, improving the activation and cytolytic activity of NK cells using cytokines or analogues and modifying chimeric antigen receptors to increase specificity and targeting NK cells. However, research regarding the application of NK cells in immunotherapy is limited. This article focuses on recent discoveries about using NK cells to prevent and treat cervical cancer and the possibility of cellular immunotherapy becoming one of the best strategies to exploit the immune system to fight tumours.Adriana Gutiérrez-HoyaIsabel Soto-CruzMDPI AGarticlecervical cancerNK cellsHPVimmune systemimmunotherapyBiology (General)QH301-705.5ENCells, Vol 10, Iss 3104, p 3104 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cervical cancer NK cells HPV immune system immunotherapy Biology (General) QH301-705.5
spellingShingle	cervical cancer NK cells HPV immune system immunotherapy Biology (General) QH301-705.5 Adriana Gutiérrez-Hoya Isabel Soto-Cruz NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy
description	Cervical cancer is one of the most prevalent gynaecological malignancies worldwide and is related to human papillomavirus (HPV) infection, viral persistence, progression, and invasion. Therefore, the immune response is linked to HPV status. Natural killer (NK) cells play a central role against virus-infected cells and tumours through a delicate balance between activating and inhibitory receptors and secretion of cytokines and chemokines. These cells also play a crucial role in tumour immunosurveillance. For these reasons, there is growing interest in harnessing NK cells as an immunotherapy for cervical cancer. These studies are diverse and include many strategies such as transferring activated autologous or allogeneic NK cells, improving the activation and cytolytic activity of NK cells using cytokines or analogues and modifying chimeric antigen receptors to increase specificity and targeting NK cells. However, research regarding the application of NK cells in immunotherapy is limited. This article focuses on recent discoveries about using NK cells to prevent and treat cervical cancer and the possibility of cellular immunotherapy becoming one of the best strategies to exploit the immune system to fight tumours.
format	article
author	Adriana Gutiérrez-Hoya Isabel Soto-Cruz
author_facet	Adriana Gutiérrez-Hoya Isabel Soto-Cruz
author_sort	Adriana Gutiérrez-Hoya
title	NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy
title_short	NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy
title_full	NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy
title_fullStr	NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy
title_full_unstemmed	NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy
title_sort	nk cell regulation in cervical cancer and strategies for immunotherapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/070e4ddd1d124dc7b1fd5db5b8b6c760
work_keys_str_mv	AT adrianagutierrezhoya nkcellregulationincervicalcancerandstrategiesforimmunotherapy AT isabelsotocruz nkcellregulationincervicalcancerandstrategiesforimmunotherapy
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NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy

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