Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Dysregulation of intracellular calcium is reported in Alzheimer’s disease. Here the authors show that loss of the mitochondrial Na+ /Ca2 + exchanger, NCLX – primary route of mitochondrial calcium efflux, precedes neuronal pathology in experimental models and contributes to Alzheimer’s disease progre...

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Autores principales:	Pooja Jadiya, Devin W. Kolmetzky, Dhanendra Tomar, Antonio Di Meco, Alyssa A. Lombardi, Jonathan P. Lambert, Timothy S. Luongo, Marthe H. Ludtmann, Domenico Praticò, John W. Elrod
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/070ff9071c5f47e28fd020946d9949fc
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spelling	oai:doaj.org-article:070ff9071c5f47e28fd020946d9949fc2021-12-02T16:58:28ZImpaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease10.1038/s41467-019-11813-62041-1723https://doaj.org/article/070ff9071c5f47e28fd020946d9949fc2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11813-6https://doaj.org/toc/2041-1723Dysregulation of intracellular calcium is reported in Alzheimer’s disease. Here the authors show that loss of the mitochondrial Na+ /Ca2 + exchanger, NCLX – primary route of mitochondrial calcium efflux, precedes neuronal pathology in experimental models and contributes to Alzheimer’s disease progression.Pooja JadiyaDevin W. KolmetzkyDhanendra TomarAntonio Di MecoAlyssa A. LombardiJonathan P. LambertTimothy S. LuongoMarthe H. LudtmannDomenico PraticòJohn W. ElrodNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pooja Jadiya Devin W. Kolmetzky Dhanendra Tomar Antonio Di Meco Alyssa A. Lombardi Jonathan P. Lambert Timothy S. Luongo Marthe H. Ludtmann Domenico Praticò John W. Elrod Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
description	Dysregulation of intracellular calcium is reported in Alzheimer’s disease. Here the authors show that loss of the mitochondrial Na+ /Ca2 + exchanger, NCLX – primary route of mitochondrial calcium efflux, precedes neuronal pathology in experimental models and contributes to Alzheimer’s disease progression.
format	article
author	Pooja Jadiya Devin W. Kolmetzky Dhanendra Tomar Antonio Di Meco Alyssa A. Lombardi Jonathan P. Lambert Timothy S. Luongo Marthe H. Ludtmann Domenico Praticò John W. Elrod
author_facet	Pooja Jadiya Devin W. Kolmetzky Dhanendra Tomar Antonio Di Meco Alyssa A. Lombardi Jonathan P. Lambert Timothy S. Luongo Marthe H. Ludtmann Domenico Praticò John W. Elrod
author_sort	Pooja Jadiya
title	Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
title_short	Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
title_full	Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
title_fullStr	Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
title_full_unstemmed	Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
title_sort	impaired mitochondrial calcium efflux contributes to disease progression in models of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/070ff9071c5f47e28fd020946d9949fc
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Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

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