Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Dysregulation of intracellular calcium is reported in Alzheimer’s disease. Here the authors show that loss of the mitochondrial Na+ /Ca2 + exchanger, NCLX – primary route of mitochondrial calcium efflux, precedes neuronal pathology in experimental models and contributes to Alzheimer’s disease progre...

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Autores principales: Pooja Jadiya, Devin W. Kolmetzky, Dhanendra Tomar, Antonio Di Meco, Alyssa A. Lombardi, Jonathan P. Lambert, Timothy S. Luongo, Marthe H. Ludtmann, Domenico Praticò, John W. Elrod
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/070ff9071c5f47e28fd020946d9949fc
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