The role of NMDAR antibody in the etiopathogenesis of schizophrenia

Damla Timucin,1 Osman Ozdemir,2 Mehmet Parlak3 1Department of Psychiatry, University of Health Sciences, Van Training and Research Hospital, Van, 2Department of Psychiatry, 3Department of Microbiology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey Abstract: Many authors have re...

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Autores principales:	Timucin D, Ozdemir O, Parlak M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	schizophrenia N-acetyl d-aspartate receptor glutamate antibody Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/07108052c5ed46b1b5d810fd9cdb5a87
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spelling	oai:doaj.org-article:07108052c5ed46b1b5d810fd9cdb5a872021-12-02T06:02:18ZThe role of NMDAR antibody in the etiopathogenesis of schizophrenia1178-2021https://doaj.org/article/07108052c5ed46b1b5d810fd9cdb5a872016-09-01T00:00:00Zhttps://www.dovepress.com/the-role-of-nmdar-antibody-in-the-etiopathogenesis-of-schizophrenia-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Damla Timucin,1 Osman Ozdemir,2 Mehmet Parlak3 1Department of Psychiatry, University of Health Sciences, Van Training and Research Hospital, Van, 2Department of Psychiatry, 3Department of Microbiology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey Abstract: Many authors have reported the presence of serum NMDAR antibodies in varying proportions of patients with schizophrenia; however, many others have not been able to confirm this. Because of the contradictory findings reported in various studies, more definitive research on this issue is required. Hence, we have investigated the NR1 subunit of NMDAR antibodies in patients with schizophrenia (n=49) and healthy controls (n=48). None of the investigated patients with schizophrenia and none of the healthy controls showed positive antibody against the NR1 subunit of the NMDAR. On the basis of this result, we conclude that the NR1 subunit of the NMDAR antibodies does not seem to have a role in schizophrenia. Keywords: schizophrenia, N-acetyl d-aspartate receptor, glutamate, antibodyTimucin DOzdemir OParlak MDove Medical PressarticleschizophreniaN-acetyl d-aspartate receptorglutamateantibodyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2327-2332 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia N-acetyl d-aspartate receptor glutamate antibody Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	schizophrenia N-acetyl d-aspartate receptor glutamate antibody Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Timucin D Ozdemir O Parlak M The role of NMDAR antibody in the etiopathogenesis of schizophrenia
description	Damla Timucin,1 Osman Ozdemir,2 Mehmet Parlak3 1Department of Psychiatry, University of Health Sciences, Van Training and Research Hospital, Van, 2Department of Psychiatry, 3Department of Microbiology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey Abstract: Many authors have reported the presence of serum NMDAR antibodies in varying proportions of patients with schizophrenia; however, many others have not been able to confirm this. Because of the contradictory findings reported in various studies, more definitive research on this issue is required. Hence, we have investigated the NR1 subunit of NMDAR antibodies in patients with schizophrenia (n=49) and healthy controls (n=48). None of the investigated patients with schizophrenia and none of the healthy controls showed positive antibody against the NR1 subunit of the NMDAR. On the basis of this result, we conclude that the NR1 subunit of the NMDAR antibodies does not seem to have a role in schizophrenia. Keywords: schizophrenia, N-acetyl d-aspartate receptor, glutamate, antibody
format	article
author	Timucin D Ozdemir O Parlak M
author_facet	Timucin D Ozdemir O Parlak M
author_sort	Timucin D
title	The role of NMDAR antibody in the etiopathogenesis of schizophrenia
title_short	The role of NMDAR antibody in the etiopathogenesis of schizophrenia
title_full	The role of NMDAR antibody in the etiopathogenesis of schizophrenia
title_fullStr	The role of NMDAR antibody in the etiopathogenesis of schizophrenia
title_full_unstemmed	The role of NMDAR antibody in the etiopathogenesis of schizophrenia
title_sort	role of nmdar antibody in the etiopathogenesis of schizophrenia
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/07108052c5ed46b1b5d810fd9cdb5a87
work_keys_str_mv	AT timucind theroleofnmdarantibodyintheetiopathogenesisofschizophrenia AT ozdemiro theroleofnmdarantibodyintheetiopathogenesisofschizophrenia AT parlakm theroleofnmdarantibodyintheetiopathogenesisofschizophrenia AT timucind roleofnmdarantibodyintheetiopathogenesisofschizophrenia AT ozdemiro roleofnmdarantibodyintheetiopathogenesisofschizophrenia AT parlakm roleofnmdarantibodyintheetiopathogenesisofschizophrenia
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The role of NMDAR antibody in the etiopathogenesis of schizophrenia

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