Hydrogels: 3D Drug Delivery Systems for Nanoparticles and Extracellular Vesicles

Synthetic and naturally occurring nano-sized particles present versatile vehicles for the delivery of therapy in a range of clinical settings. Their small size and modifiable physicochemical properties support refinement of targeting capabilities, immune response, and therapeutic cargo, but rapid cl...

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Autores principales:	Yashna Chabria, Garry P. Duffy, Aoife J Lowery, Róisín M. Dwyer
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanoparticles extracellular vesicles hydrogels biocompatible bioscaffolds tissue regeneration Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0712083151174e13ab19ca0c45c5b6e1
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spelling	oai:doaj.org-article:0712083151174e13ab19ca0c45c5b6e12021-11-25T16:50:54ZHydrogels: 3D Drug Delivery Systems for Nanoparticles and Extracellular Vesicles10.3390/biomedicines91116942227-9059https://doaj.org/article/0712083151174e13ab19ca0c45c5b6e12021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1694https://doaj.org/toc/2227-9059Synthetic and naturally occurring nano-sized particles present versatile vehicles for the delivery of therapy in a range of clinical settings. Their small size and modifiable physicochemical properties support refinement of targeting capabilities, immune response, and therapeutic cargo, but rapid clearance from the body and limited efficacy remain a major challenge. This highlights the need for a local sustained delivery system for nanoparticles (NPs) and extracellular vesicles (EVs) at the target site that will ensure prolonged exposure, maximum efficacy and dose, and minimal toxicity. Biocompatible hydrogels loaded with therapeutic NPs/EVs hold immense promise as cell-free sustained and targeted delivery systems in a range of disease settings. These bioscaffolds ensure retention of the nano-sized particles at the target site and can also act as controlled release systems for therapeutics over a prolonged period of time. The encapsulation of stimuli sensitive components into hydrogels supports the release of the content on-demand. In this review, we highlight the prospect of the sustained and prolonged delivery of these nano-sized therapeutic entities from hydrogels for broad applications spanning tissue regeneration and cancer treatment. Further understanding of the parameters controlling the release rate of these particles and efficient transfer of cargo to target cells will be fundamental to success.Yashna ChabriaGarry P. DuffyAoife J LoweryRóisín M. DwyerMDPI AGarticlenanoparticlesextracellular vesicleshydrogelsbiocompatiblebioscaffoldstissue regenerationBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1694, p 1694 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticles extracellular vesicles hydrogels biocompatible bioscaffolds tissue regeneration Biology (General) QH301-705.5
spellingShingle	nanoparticles extracellular vesicles hydrogels biocompatible bioscaffolds tissue regeneration Biology (General) QH301-705.5 Yashna Chabria Garry P. Duffy Aoife J Lowery Róisín M. Dwyer Hydrogels: 3D Drug Delivery Systems for Nanoparticles and Extracellular Vesicles
description	Synthetic and naturally occurring nano-sized particles present versatile vehicles for the delivery of therapy in a range of clinical settings. Their small size and modifiable physicochemical properties support refinement of targeting capabilities, immune response, and therapeutic cargo, but rapid clearance from the body and limited efficacy remain a major challenge. This highlights the need for a local sustained delivery system for nanoparticles (NPs) and extracellular vesicles (EVs) at the target site that will ensure prolonged exposure, maximum efficacy and dose, and minimal toxicity. Biocompatible hydrogels loaded with therapeutic NPs/EVs hold immense promise as cell-free sustained and targeted delivery systems in a range of disease settings. These bioscaffolds ensure retention of the nano-sized particles at the target site and can also act as controlled release systems for therapeutics over a prolonged period of time. The encapsulation of stimuli sensitive components into hydrogels supports the release of the content on-demand. In this review, we highlight the prospect of the sustained and prolonged delivery of these nano-sized therapeutic entities from hydrogels for broad applications spanning tissue regeneration and cancer treatment. Further understanding of the parameters controlling the release rate of these particles and efficient transfer of cargo to target cells will be fundamental to success.
format	article
author	Yashna Chabria Garry P. Duffy Aoife J Lowery Róisín M. Dwyer
author_facet	Yashna Chabria Garry P. Duffy Aoife J Lowery Róisín M. Dwyer
author_sort	Yashna Chabria
title	Hydrogels: 3D Drug Delivery Systems for Nanoparticles and Extracellular Vesicles
title_short	Hydrogels: 3D Drug Delivery Systems for Nanoparticles and Extracellular Vesicles
title_full	Hydrogels: 3D Drug Delivery Systems for Nanoparticles and Extracellular Vesicles
title_fullStr	Hydrogels: 3D Drug Delivery Systems for Nanoparticles and Extracellular Vesicles
title_full_unstemmed	Hydrogels: 3D Drug Delivery Systems for Nanoparticles and Extracellular Vesicles
title_sort	hydrogels: 3d drug delivery systems for nanoparticles and extracellular vesicles
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0712083151174e13ab19ca0c45c5b6e1
work_keys_str_mv	AT yashnachabria hydrogels3ddrugdeliverysystemsfornanoparticlesandextracellularvesicles AT garrypduffy hydrogels3ddrugdeliverysystemsfornanoparticlesandextracellularvesicles AT aoifejlowery hydrogels3ddrugdeliverysystemsfornanoparticlesandextracellularvesicles AT roisinmdwyer hydrogels3ddrugdeliverysystemsfornanoparticlesandextracellularvesicles
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Hydrogels: 3D Drug Delivery Systems for Nanoparticles and Extracellular Vesicles

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