The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology

Abstract We explored the independent risk factors associated with cases of spontaneous abortion in infertile patients treated with human-assisted reproductive technology (ART) and established a smooth curve fit and perform a threshold effect analysis can provide guidance and a valuable reference for...

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Autores principales:	Fei Li, AiQin Niu, XingMei Feng, Ying Yan, Ying Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0713bbb4e0d446cf91e15bda896609ff
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spelling	oai:doaj.org-article:0713bbb4e0d446cf91e15bda896609ff2021-12-02T15:02:31ZThe threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology10.1038/s41598-021-90970-52045-2322https://doaj.org/article/0713bbb4e0d446cf91e15bda896609ff2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90970-5https://doaj.org/toc/2045-2322Abstract We explored the independent risk factors associated with cases of spontaneous abortion in infertile patients treated with human-assisted reproductive technology (ART) and established a smooth curve fit and perform a threshold effect analysis can provide guidance and a valuable reference for predicting the probability of spontaneous abortion. This was a retrospective cohort study of 16,097 patients successfully conceived with ART in Shangqiu First People's Hospital from June 2013 to December 2018. Overall, 2,378 (14.77%) had an abortion and 13,719 (85.23%) did not have an abortion. Multivariate logistic regression analysis showed that female age (OR 1.050; 95% CI 1.032–1.069; P < 0.001), male age (OR 1.100; 95% CI 1.086–1.115; P < 0.001), follicular-stimulating hormone (OR 1.049; 95% CI 1.022–1.076; P < 0.001), anti-Mullerian hormone (OR 0.893; 95% CI 0.862–0.925; P < 0.001) and the number of fetuses at pregnancy diagnosis were independent factors associated with spontaneous abortion. The threshold effect analysis found that when female age > 32 years (cut-off point) old, age and the risk of spontaneous abortion were positively correlated. When follicular-stimulating hormone > 6.1 IU/L (cut-off point), follicular-stimulating hormone was positively correlated with the occurrence of spontaneous abortion, When anti-Mullerian hormone ≤ 3.1 ng/mL (cut-off point), anti-Mullerian hormone was negatively correlated with the occurrence of spontaneous abortion and there was a linear positive correlation between antral Follicle Counting and live birth. In addition, the older the male age, the higher the incidence of abortion. The smooth curve fit and threshold effect analyses can provide a more detailed estimate of the probability of spontaneous abortion for pregnant couples.Fei LiAiQin NiuXingMei FengYing YanYing ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fei Li AiQin Niu XingMei Feng Ying Yan Ying Chen The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology
description	Abstract We explored the independent risk factors associated with cases of spontaneous abortion in infertile patients treated with human-assisted reproductive technology (ART) and established a smooth curve fit and perform a threshold effect analysis can provide guidance and a valuable reference for predicting the probability of spontaneous abortion. This was a retrospective cohort study of 16,097 patients successfully conceived with ART in Shangqiu First People's Hospital from June 2013 to December 2018. Overall, 2,378 (14.77%) had an abortion and 13,719 (85.23%) did not have an abortion. Multivariate logistic regression analysis showed that female age (OR 1.050; 95% CI 1.032–1.069; P < 0.001), male age (OR 1.100; 95% CI 1.086–1.115; P < 0.001), follicular-stimulating hormone (OR 1.049; 95% CI 1.022–1.076; P < 0.001), anti-Mullerian hormone (OR 0.893; 95% CI 0.862–0.925; P < 0.001) and the number of fetuses at pregnancy diagnosis were independent factors associated with spontaneous abortion. The threshold effect analysis found that when female age > 32 years (cut-off point) old, age and the risk of spontaneous abortion were positively correlated. When follicular-stimulating hormone > 6.1 IU/L (cut-off point), follicular-stimulating hormone was positively correlated with the occurrence of spontaneous abortion, When anti-Mullerian hormone ≤ 3.1 ng/mL (cut-off point), anti-Mullerian hormone was negatively correlated with the occurrence of spontaneous abortion and there was a linear positive correlation between antral Follicle Counting and live birth. In addition, the older the male age, the higher the incidence of abortion. The smooth curve fit and threshold effect analyses can provide a more detailed estimate of the probability of spontaneous abortion for pregnant couples.
format	article
author	Fei Li AiQin Niu XingMei Feng Ying Yan Ying Chen
author_facet	Fei Li AiQin Niu XingMei Feng Ying Yan Ying Chen
author_sort	Fei Li
title	The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology
title_short	The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology
title_full	The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology
title_fullStr	The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology
title_full_unstemmed	The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology
title_sort	threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0713bbb4e0d446cf91e15bda896609ff
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The threshold effect of factors associated with spontaneous abortion in human-assisted reproductive technology

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