Genotype by random environmental interactions gives an advantage to non-favored minor alleles

Abstract Fixation probability, the probability that the frequency of a newly arising mutation in a population will eventually reach unity, is a fundamental quantity in evolutionary genetics. Here we use a number of models (several versions of the Moran model and the haploid Wright-Fisher model) to e...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. Mahdipour-Shirayeh, A. H. Darooneh, A. D. Long, N. L. Komarova, M. Kohandel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0715a41feeaa488ab42f9cc9614299d2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0715a41feeaa488ab42f9cc9614299d2
record_format	dspace
spelling	oai:doaj.org-article:0715a41feeaa488ab42f9cc9614299d22021-12-02T11:40:43ZGenotype by random environmental interactions gives an advantage to non-favored minor alleles10.1038/s41598-017-05375-02045-2322https://doaj.org/article/0715a41feeaa488ab42f9cc9614299d22017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05375-0https://doaj.org/toc/2045-2322Abstract Fixation probability, the probability that the frequency of a newly arising mutation in a population will eventually reach unity, is a fundamental quantity in evolutionary genetics. Here we use a number of models (several versions of the Moran model and the haploid Wright-Fisher model) to examine fixation probabilities for a constant size population where the fitness is a random function of both allelic state and spatial position, despite neither allele being favored on average. The concept of fitness varying with respect to both genotype and environment is important in models of cancer initiation and progression, bacterial dynamics, and drug resistance. Under our model spatial heterogeneity redefines the notion of neutrality for a newly arising mutation, as such mutations fix at a higher rate than that predicted under neutrality. The increased fixation probability appears to be due to rare alleles having an advantage. The magnitude of this effect can be large, and is an increasing function of the spatial variance and skew in fitness. The effect is largest when the fitness values of the mutants and wild types are anti-correlated across environments. We discuss results for both a spatial ring geometry of cells (such as that of a colonic crypt), a 2D lattice and a mass-action (complete graph) arrangement.A. Mahdipour-ShirayehA. H. DaroonehA. D. LongN. L. KomarovaM. KohandelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Mahdipour-Shirayeh A. H. Darooneh A. D. Long N. L. Komarova M. Kohandel Genotype by random environmental interactions gives an advantage to non-favored minor alleles
description	Abstract Fixation probability, the probability that the frequency of a newly arising mutation in a population will eventually reach unity, is a fundamental quantity in evolutionary genetics. Here we use a number of models (several versions of the Moran model and the haploid Wright-Fisher model) to examine fixation probabilities for a constant size population where the fitness is a random function of both allelic state and spatial position, despite neither allele being favored on average. The concept of fitness varying with respect to both genotype and environment is important in models of cancer initiation and progression, bacterial dynamics, and drug resistance. Under our model spatial heterogeneity redefines the notion of neutrality for a newly arising mutation, as such mutations fix at a higher rate than that predicted under neutrality. The increased fixation probability appears to be due to rare alleles having an advantage. The magnitude of this effect can be large, and is an increasing function of the spatial variance and skew in fitness. The effect is largest when the fitness values of the mutants and wild types are anti-correlated across environments. We discuss results for both a spatial ring geometry of cells (such as that of a colonic crypt), a 2D lattice and a mass-action (complete graph) arrangement.
format	article
author	A. Mahdipour-Shirayeh A. H. Darooneh A. D. Long N. L. Komarova M. Kohandel
author_facet	A. Mahdipour-Shirayeh A. H. Darooneh A. D. Long N. L. Komarova M. Kohandel
author_sort	A. Mahdipour-Shirayeh
title	Genotype by random environmental interactions gives an advantage to non-favored minor alleles
title_short	Genotype by random environmental interactions gives an advantage to non-favored minor alleles
title_full	Genotype by random environmental interactions gives an advantage to non-favored minor alleles
title_fullStr	Genotype by random environmental interactions gives an advantage to non-favored minor alleles
title_full_unstemmed	Genotype by random environmental interactions gives an advantage to non-favored minor alleles
title_sort	genotype by random environmental interactions gives an advantage to non-favored minor alleles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0715a41feeaa488ab42f9cc9614299d2
work_keys_str_mv	AT amahdipourshirayeh genotypebyrandomenvironmentalinteractionsgivesanadvantagetononfavoredminoralleles AT ahdarooneh genotypebyrandomenvironmentalinteractionsgivesanadvantagetononfavoredminoralleles AT adlong genotypebyrandomenvironmentalinteractionsgivesanadvantagetononfavoredminoralleles AT nlkomarova genotypebyrandomenvironmentalinteractionsgivesanadvantagetononfavoredminoralleles AT mkohandel genotypebyrandomenvironmentalinteractionsgivesanadvantagetononfavoredminoralleles
_version_	1718395560595030016

Genotype by random environmental interactions gives an advantage to non-favored minor alleles

Ejemplares similares