Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome

Takotsubo syndrome is a serious complication of labor. Although the pathophysiologic role of excessive sympathetic activation is established in this process, concurrent vagal responses have not been adequately described. Moreover, it remains unclear whether autonomic activity depends on the mode of...

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Autores principales:	Georgios E. Papadopoulos, Theoxaris I. Evaggelou, Errikos K. Moulias, Orestis Tsonis, Konstantinos C. Zekios, Dimitrios N. Nikas, Petros Tzimas, Minas Paschopoulos, Theofilos M. Kolettis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sympathetic responses vagal responses cesarean delivery vaginal delivery Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/0715ce9168b94514939bf11005a9b7de
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spelling	oai:doaj.org-article:0715ce9168b94514939bf11005a9b7de2021-11-25T18:00:23ZAutonomic Responses during Labor: Potential Implications for Takotsubo Syndrome10.3390/jcdd81101522308-3425https://doaj.org/article/0715ce9168b94514939bf11005a9b7de2021-11-01T00:00:00Zhttps://www.mdpi.com/2308-3425/8/11/152https://doaj.org/toc/2308-3425Takotsubo syndrome is a serious complication of labor. Although the pathophysiologic role of excessive sympathetic activation is established in this process, concurrent vagal responses have not been adequately described. Moreover, it remains unclear whether autonomic activity depends on the mode of delivery. Here, we explored the hypothesis that the different management of cesarean and vaginal delivery may elicit diverse responses affecting both autonomic arms. For this aim, continuous electrocardiographic recording was performed in 20 women during labor, and non-invasive indices of sympathetic and vagal activity were compared between the two modes of delivery. We report sympathetic prevalence during cesarean delivery, caused by marked vagal withdrawal, whereas autonomic activity was rather stable during vaginal delivery. These differences may be attributed to the effects of anesthesia during cesarean delivery, along with the protective effects of oxytocin administration during vaginal delivery. Our results provide further insights on autonomic responses during labor that may prove useful in the prevention of complications, such as takotsubo syndrome.Georgios E. PapadopoulosTheoxaris I. EvaggelouErrikos K. MouliasOrestis TsonisKonstantinos C. ZekiosDimitrios N. NikasPetros TzimasMinas PaschopoulosTheofilos M. KolettisMDPI AGarticlesympathetic responsesvagal responsescesarean deliveryvaginal deliveryDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Cardiovascular Development and Disease, Vol 8, Iss 152, p 152 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sympathetic responses vagal responses cesarean delivery vaginal delivery Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	sympathetic responses vagal responses cesarean delivery vaginal delivery Diseases of the circulatory (Cardiovascular) system RC666-701 Georgios E. Papadopoulos Theoxaris I. Evaggelou Errikos K. Moulias Orestis Tsonis Konstantinos C. Zekios Dimitrios N. Nikas Petros Tzimas Minas Paschopoulos Theofilos M. Kolettis Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome
description	Takotsubo syndrome is a serious complication of labor. Although the pathophysiologic role of excessive sympathetic activation is established in this process, concurrent vagal responses have not been adequately described. Moreover, it remains unclear whether autonomic activity depends on the mode of delivery. Here, we explored the hypothesis that the different management of cesarean and vaginal delivery may elicit diverse responses affecting both autonomic arms. For this aim, continuous electrocardiographic recording was performed in 20 women during labor, and non-invasive indices of sympathetic and vagal activity were compared between the two modes of delivery. We report sympathetic prevalence during cesarean delivery, caused by marked vagal withdrawal, whereas autonomic activity was rather stable during vaginal delivery. These differences may be attributed to the effects of anesthesia during cesarean delivery, along with the protective effects of oxytocin administration during vaginal delivery. Our results provide further insights on autonomic responses during labor that may prove useful in the prevention of complications, such as takotsubo syndrome.
format	article
author	Georgios E. Papadopoulos Theoxaris I. Evaggelou Errikos K. Moulias Orestis Tsonis Konstantinos C. Zekios Dimitrios N. Nikas Petros Tzimas Minas Paschopoulos Theofilos M. Kolettis
author_facet	Georgios E. Papadopoulos Theoxaris I. Evaggelou Errikos K. Moulias Orestis Tsonis Konstantinos C. Zekios Dimitrios N. Nikas Petros Tzimas Minas Paschopoulos Theofilos M. Kolettis
author_sort	Georgios E. Papadopoulos
title	Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome
title_short	Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome
title_full	Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome
title_fullStr	Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome
title_full_unstemmed	Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome
title_sort	autonomic responses during labor: potential implications for takotsubo syndrome
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0715ce9168b94514939bf11005a9b7de
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_version_	1718411722108174336

Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome

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