Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting

The ability of HIV to alternate between acute and latent forms is thought to rely on a transcriptional feedback loop where polymerase pausing is released by the viral protein Tat. Here, the authors show that viral genome transcription can occur in a burst-like stochastic manner in the absence of Tat...

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Autores principales:	Katjana Tantale, Encar Garcia-Oliver, Marie-Cécile Robert, Adèle L’Hostis, Yueyuxiao Yang, Nikolay Tsanov, Rachel Topno, Thierry Gostan, Alja Kozulic-Pirher, Meenakshi Basu-Shrivastava, Kamalika Mukherjee, Vera Slaninova, Jean-Christophe Andrau, Florian Mueller, Eugenia Basyuk, Ovidiu Radulescu, Edouard Bertrand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/07173f9934654a55b481d64dbbdee8ab
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spelling	oai:doaj.org-article:07173f9934654a55b481d64dbbdee8ab2021-12-02T16:17:57ZStochastic pausing at latent HIV-1 promoters generates transcriptional bursting10.1038/s41467-021-24462-52041-1723https://doaj.org/article/07173f9934654a55b481d64dbbdee8ab2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24462-5https://doaj.org/toc/2041-1723The ability of HIV to alternate between acute and latent forms is thought to rely on a transcriptional feedback loop where polymerase pausing is released by the viral protein Tat. Here, the authors show that viral genome transcription can occur in a burst-like stochastic manner in the absence of Tat.Katjana TantaleEncar Garcia-OliverMarie-Cécile RobertAdèle L’HostisYueyuxiao YangNikolay TsanovRachel TopnoThierry GostanAlja Kozulic-PirherMeenakshi Basu-ShrivastavaKamalika MukherjeeVera SlaninovaJean-Christophe AndrauFlorian MuellerEugenia BasyukOvidiu RadulescuEdouard BertrandNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katjana Tantale Encar Garcia-Oliver Marie-Cécile Robert Adèle L’Hostis Yueyuxiao Yang Nikolay Tsanov Rachel Topno Thierry Gostan Alja Kozulic-Pirher Meenakshi Basu-Shrivastava Kamalika Mukherjee Vera Slaninova Jean-Christophe Andrau Florian Mueller Eugenia Basyuk Ovidiu Radulescu Edouard Bertrand Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting
description	The ability of HIV to alternate between acute and latent forms is thought to rely on a transcriptional feedback loop where polymerase pausing is released by the viral protein Tat. Here, the authors show that viral genome transcription can occur in a burst-like stochastic manner in the absence of Tat.
format	article
author	Katjana Tantale Encar Garcia-Oliver Marie-Cécile Robert Adèle L’Hostis Yueyuxiao Yang Nikolay Tsanov Rachel Topno Thierry Gostan Alja Kozulic-Pirher Meenakshi Basu-Shrivastava Kamalika Mukherjee Vera Slaninova Jean-Christophe Andrau Florian Mueller Eugenia Basyuk Ovidiu Radulescu Edouard Bertrand
author_facet	Katjana Tantale Encar Garcia-Oliver Marie-Cécile Robert Adèle L’Hostis Yueyuxiao Yang Nikolay Tsanov Rachel Topno Thierry Gostan Alja Kozulic-Pirher Meenakshi Basu-Shrivastava Kamalika Mukherjee Vera Slaninova Jean-Christophe Andrau Florian Mueller Eugenia Basyuk Ovidiu Radulescu Edouard Bertrand
author_sort	Katjana Tantale
title	Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting
title_short	Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting
title_full	Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting
title_fullStr	Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting
title_full_unstemmed	Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting
title_sort	stochastic pausing at latent hiv-1 promoters generates transcriptional bursting
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07173f9934654a55b481d64dbbdee8ab
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Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting

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