A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection

A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection

ABSTRACT Encephalomyocarditis virus (EMCV) is a picornavirus that produces lytic infections in murine and human cells. Employing a genome-wide CRISPR-Cas9 knockout screen to find host factors required for EMCV infection, we identified a role for ADAM9 in EMCV infection. CRISPR-mediated deletion of A...

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Autores principales: Lindsey E. Bazzone, Michael King, Christopher R. MacKay, Pyae P. Kyawe, Paul Meraner, Daniel Lindstrom, Joselyn Rojas-Quintero, Caroline A. Owen, Jennifer P. Wang, Abraham L. Brass, Evelyn A. Kurt-Jones, Robert W. Finberg
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
a disintegrin and metalloproteinase 9 domain (ADAM9)
encephalomyocarditis virus
functional genomic screen
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/0718071866f9446d8c16a518b045e864
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https://doaj.org/article/0718071866f9446d8c16a518b045e864

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