Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype

Abstract Breast cancer is the most common cancer in women worldwide and metastatic dissemination is the principal factor related to death by this disease. Breast cancer stem cells (bCSC) are thought to be responsible for metastasis and chemoresistance. In this study, based on whole transcriptome ana...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	W. A. da Silveira, P. V. B. Palma, R. D. Sicchieri, R. A. R. Villacis, L. R. M. Mandarano, T. M. G. Oliveira, H. M. R. Antonio, J. M. Andrade, V. F. Muglia, S. R. Rogatto, C. Theillet, S. du Manoir, D. G. Tiezzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0719ec218d9b4cb0a91c0d2eacbe4d9f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0719ec218d9b4cb0a91c0d2eacbe4d9f
record_format	dspace
spelling	oai:doaj.org-article:0719ec218d9b4cb0a91c0d2eacbe4d9f2021-12-02T15:06:11ZTranscription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype10.1038/s41598-017-02761-62045-2322https://doaj.org/article/0719ec218d9b4cb0a91c0d2eacbe4d9f2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02761-6https://doaj.org/toc/2045-2322Abstract Breast cancer is the most common cancer in women worldwide and metastatic dissemination is the principal factor related to death by this disease. Breast cancer stem cells (bCSC) are thought to be responsible for metastasis and chemoresistance. In this study, based on whole transcriptome analysis from putative bCSC and reverse engineering of transcription control networks, we identified two networks associated with this phenotype. One controlled by SNAI2, TWIST1, BNC2, PRRX1 and TBX5 drives a mesenchymal or CSC-like phenotype. The second network is controlled by the SCML4, ZNF831, SP140 and IKZF3 transcription factors which correspond to immune response modulators. Immune response network expression is correlated with pathological response to chemotherapy, and in the Basal subtype is related to better recurrence-free survival. In patient-derived xenografts, the expression of these networks in patient tumours is predictive of engraftment success. Our findings point out a potential molecular mechanism underlying the balance between immune surveillance and EMT activation in breast cancer. This molecular mechanism may be useful to the development of new target therapies.W. A. da SilveiraP. V. B. PalmaR. D. SicchieriR. A. R. VillacisL. R. M. MandaranoT. M. G. OliveiraH. M. R. AntonioJ. M. AndradeV. F. MugliaS. R. RogattoC. TheilletS. du ManoirD. G. TiezziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q W. A. da Silveira P. V. B. Palma R. D. Sicchieri R. A. R. Villacis L. R. M. Mandarano T. M. G. Oliveira H. M. R. Antonio J. M. Andrade V. F. Muglia S. R. Rogatto C. Theillet S. du Manoir D. G. Tiezzi Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype
description	Abstract Breast cancer is the most common cancer in women worldwide and metastatic dissemination is the principal factor related to death by this disease. Breast cancer stem cells (bCSC) are thought to be responsible for metastasis and chemoresistance. In this study, based on whole transcriptome analysis from putative bCSC and reverse engineering of transcription control networks, we identified two networks associated with this phenotype. One controlled by SNAI2, TWIST1, BNC2, PRRX1 and TBX5 drives a mesenchymal or CSC-like phenotype. The second network is controlled by the SCML4, ZNF831, SP140 and IKZF3 transcription factors which correspond to immune response modulators. Immune response network expression is correlated with pathological response to chemotherapy, and in the Basal subtype is related to better recurrence-free survival. In patient-derived xenografts, the expression of these networks in patient tumours is predictive of engraftment success. Our findings point out a potential molecular mechanism underlying the balance between immune surveillance and EMT activation in breast cancer. This molecular mechanism may be useful to the development of new target therapies.
format	article
author	W. A. da Silveira P. V. B. Palma R. D. Sicchieri R. A. R. Villacis L. R. M. Mandarano T. M. G. Oliveira H. M. R. Antonio J. M. Andrade V. F. Muglia S. R. Rogatto C. Theillet S. du Manoir D. G. Tiezzi
author_facet	W. A. da Silveira P. V. B. Palma R. D. Sicchieri R. A. R. Villacis L. R. M. Mandarano T. M. G. Oliveira H. M. R. Antonio J. M. Andrade V. F. Muglia S. R. Rogatto C. Theillet S. du Manoir D. G. Tiezzi
author_sort	W. A. da Silveira
title	Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype
title_short	Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype
title_full	Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype
title_fullStr	Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype
title_full_unstemmed	Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype
title_sort	transcription factor networks derived from breast cancer stem cells control the immune response in the basal subtype
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0719ec218d9b4cb0a91c0d2eacbe4d9f
work_keys_str_mv	AT wadasilveira transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT pvbpalma transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT rdsicchieri transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT rarvillacis transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT lrmmandarano transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT tmgoliveira transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT hmrantonio transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT jmandrade transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT vfmuglia transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT srrogatto transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT ctheillet transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT sdumanoir transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype AT dgtiezzi transcriptionfactornetworksderivedfrombreastcancerstemcellscontroltheimmuneresponseinthebasalsubtype
_version_	1718388559235252224

Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype

Ejemplares similares