Association between proteinuria and placental pathology in preeclampsia: A retrospective study

Introduction: Preeclampsia develops due to placental insufficiency and systemic proinflammatory and antiangiogenic mediator release, with ensuing systemic endothelial dysfunction. Nephrotic-range proteinuria appears to be associated with worse pregnancy outcomes. The relationship between differing d...

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Autores principales:	Dominique Suzanne Genest, Dorothée Dal Soglio, Sylvie Girard, Evelyne Rey
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/071dd74690d94faebbf56308d0ca8643
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spelling	oai:doaj.org-article:071dd74690d94faebbf56308d0ca86432021-12-01T23:34:14ZAssociation between proteinuria and placental pathology in preeclampsia: A retrospective study2050-312110.1177/20503121211058053https://doaj.org/article/071dd74690d94faebbf56308d0ca86432021-11-01T00:00:00Zhttps://doi.org/10.1177/20503121211058053https://doaj.org/toc/2050-3121Introduction: Preeclampsia develops due to placental insufficiency and systemic proinflammatory and antiangiogenic mediator release, with ensuing systemic endothelial dysfunction. Nephrotic-range proteinuria appears to be associated with worse pregnancy outcomes. The relationship between differing degrees of proteinuria and the severity of placental alterations has not been studied. Methods: This is a single-centre retrospective comparison of 150 singleton pregnancies complicated by preeclampsia and varying degrees of proteinuria. Maternal demographic, obstetrical and fetal outcome data were obtained from chart review. The placental histologic evaluations were performed by a placental pathologist blinded to all other clinical information. Results: Preeclamptic women with massive proteinuria had evidence of more severe maternal vascular malperfusion lesions. The severity of the lesions was progressive through mild, moderate and massive proteinuria. Women with massive proteinuria had a higher incidence of renal dysfunction and severe hypertension, and had earlier preterm deliveries compared to preeclamptic women with mild and moderate proteinuria (p < 0.05). Conclusion: Preeclampsia with more severe proteinuria is associated with a higher prevalence of placental maternal vascular malperfusion.Dominique Suzanne GenestDorothée Dal SoglioSylvie GirardEvelyne ReySAGE PublishingarticleMedicine (General)R5-920ENSAGE Open Medicine, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Dominique Suzanne Genest Dorothée Dal Soglio Sylvie Girard Evelyne Rey Association between proteinuria and placental pathology in preeclampsia: A retrospective study
description	Introduction: Preeclampsia develops due to placental insufficiency and systemic proinflammatory and antiangiogenic mediator release, with ensuing systemic endothelial dysfunction. Nephrotic-range proteinuria appears to be associated with worse pregnancy outcomes. The relationship between differing degrees of proteinuria and the severity of placental alterations has not been studied. Methods: This is a single-centre retrospective comparison of 150 singleton pregnancies complicated by preeclampsia and varying degrees of proteinuria. Maternal demographic, obstetrical and fetal outcome data were obtained from chart review. The placental histologic evaluations were performed by a placental pathologist blinded to all other clinical information. Results: Preeclamptic women with massive proteinuria had evidence of more severe maternal vascular malperfusion lesions. The severity of the lesions was progressive through mild, moderate and massive proteinuria. Women with massive proteinuria had a higher incidence of renal dysfunction and severe hypertension, and had earlier preterm deliveries compared to preeclamptic women with mild and moderate proteinuria (p < 0.05). Conclusion: Preeclampsia with more severe proteinuria is associated with a higher prevalence of placental maternal vascular malperfusion.
format	article
author	Dominique Suzanne Genest Dorothée Dal Soglio Sylvie Girard Evelyne Rey
author_facet	Dominique Suzanne Genest Dorothée Dal Soglio Sylvie Girard Evelyne Rey
author_sort	Dominique Suzanne Genest
title	Association between proteinuria and placental pathology in preeclampsia: A retrospective study
title_short	Association between proteinuria and placental pathology in preeclampsia: A retrospective study
title_full	Association between proteinuria and placental pathology in preeclampsia: A retrospective study
title_fullStr	Association between proteinuria and placental pathology in preeclampsia: A retrospective study
title_full_unstemmed	Association between proteinuria and placental pathology in preeclampsia: A retrospective study
title_sort	association between proteinuria and placental pathology in preeclampsia: a retrospective study
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/071dd74690d94faebbf56308d0ca8643
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Association between proteinuria and placental pathology in preeclampsia: A retrospective study

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