Pulmonary function changes in older adults with and without metabolic syndrome

Abstract The low-grade inflammation associated with metabolic syndrome (MS) triggers functional and structural alterations in several organs. Whereas lung function impairment is well reported for older adult population, the effect of MS on functional and immunological responses in the lungs remains...

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Autores principales:	Maysa Alves Rodrigues Brandao-Rangel, Renilson Moraes-Ferreira, Manoel Carneiro Oliveira-Junior, Alana Santos-Dias, André Luis Lacerda Bachi, Giovana Gabriela-Pereira, Simone de Oliveira Freitas, Amanda Cristina Araújo-Rosa, Luis Vicente Franco Oliveira, Claudio Ricardo Frison, Wagner Luiz do Prado, Raghavan Pillai Raju, P Babu Balagopal, Rodolfo P Vieira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/07218e8e0d22440b811a1b9a940d50f2
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spelling	oai:doaj.org-article:07218e8e0d22440b811a1b9a940d50f22021-12-02T16:38:24ZPulmonary function changes in older adults with and without metabolic syndrome10.1038/s41598-021-96766-x2045-2322https://doaj.org/article/07218e8e0d22440b811a1b9a940d50f22021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96766-xhttps://doaj.org/toc/2045-2322Abstract The low-grade inflammation associated with metabolic syndrome (MS) triggers functional and structural alterations in several organs. Whereas lung function impairment is well reported for older adult population, the effect of MS on functional and immunological responses in the lungs remains unclear. In this cross-sectional study we determined whether MS alters pulmonary function, and immunological responses in older adults with MS. The study sample consisted of older adults with MS (68 ± 3 years old; n = 77) and without MS (67 ± 3 years old; n = 77). Impulse oscillometry was used to evaluate airway and tissue resistance, and reactance. Biomarkers of inflammation and fibrosis were assessed in the blood and in breath condensate. The total resistance of the respiratory system (R5Hz; p < 0.009), and the resistance of the proximal (R20Hz; p < 0.001) and distal (R5Hz–R20Hz; p < 0.004) airways were higher in MS individuals compared to those without MS. Pro-inflammatory (leptin, IL-1beta, IL-8, p < 0.001; TNF-alpha, p < 0.04) and anti-inflammatory cytokines (adiponectin, IL-1ra, IL-10, p < 0.001), anti-fibrotic (relaxin 1, relaxin 3, Klotho, p < 0.001) and pro-fibrotic (VEGF, p < 0.001) factors were increased in sera and in breath condensate individuals with MS. The results show that MS adversely affect lung mechanics, function, and immunological response in older adults. The data offer a metabolic basis for the inflammaging of the lungs and suggest the lungs as a potential therapeutic target for controlling the immune response and delaying the onset of impaired lung function in older adults with MS.Maysa Alves Rodrigues Brandao-RangelRenilson Moraes-FerreiraManoel Carneiro Oliveira-JuniorAlana Santos-DiasAndré Luis Lacerda BachiGiovana Gabriela-PereiraSimone de Oliveira FreitasAmanda Cristina Araújo-RosaLuis Vicente Franco OliveiraClaudio Ricardo FrisonWagner Luiz do PradoRaghavan Pillai RajuP Babu BalagopalRodolfo P VieiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maysa Alves Rodrigues Brandao-Rangel Renilson Moraes-Ferreira Manoel Carneiro Oliveira-Junior Alana Santos-Dias André Luis Lacerda Bachi Giovana Gabriela-Pereira Simone de Oliveira Freitas Amanda Cristina Araújo-Rosa Luis Vicente Franco Oliveira Claudio Ricardo Frison Wagner Luiz do Prado Raghavan Pillai Raju P Babu Balagopal Rodolfo P Vieira Pulmonary function changes in older adults with and without metabolic syndrome
description	Abstract The low-grade inflammation associated with metabolic syndrome (MS) triggers functional and structural alterations in several organs. Whereas lung function impairment is well reported for older adult population, the effect of MS on functional and immunological responses in the lungs remains unclear. In this cross-sectional study we determined whether MS alters pulmonary function, and immunological responses in older adults with MS. The study sample consisted of older adults with MS (68 ± 3 years old; n = 77) and without MS (67 ± 3 years old; n = 77). Impulse oscillometry was used to evaluate airway and tissue resistance, and reactance. Biomarkers of inflammation and fibrosis were assessed in the blood and in breath condensate. The total resistance of the respiratory system (R5Hz; p < 0.009), and the resistance of the proximal (R20Hz; p < 0.001) and distal (R5Hz–R20Hz; p < 0.004) airways were higher in MS individuals compared to those without MS. Pro-inflammatory (leptin, IL-1beta, IL-8, p < 0.001; TNF-alpha, p < 0.04) and anti-inflammatory cytokines (adiponectin, IL-1ra, IL-10, p < 0.001), anti-fibrotic (relaxin 1, relaxin 3, Klotho, p < 0.001) and pro-fibrotic (VEGF, p < 0.001) factors were increased in sera and in breath condensate individuals with MS. The results show that MS adversely affect lung mechanics, function, and immunological response in older adults. The data offer a metabolic basis for the inflammaging of the lungs and suggest the lungs as a potential therapeutic target for controlling the immune response and delaying the onset of impaired lung function in older adults with MS.
format	article
author	Maysa Alves Rodrigues Brandao-Rangel Renilson Moraes-Ferreira Manoel Carneiro Oliveira-Junior Alana Santos-Dias André Luis Lacerda Bachi Giovana Gabriela-Pereira Simone de Oliveira Freitas Amanda Cristina Araújo-Rosa Luis Vicente Franco Oliveira Claudio Ricardo Frison Wagner Luiz do Prado Raghavan Pillai Raju P Babu Balagopal Rodolfo P Vieira
author_facet	Maysa Alves Rodrigues Brandao-Rangel Renilson Moraes-Ferreira Manoel Carneiro Oliveira-Junior Alana Santos-Dias André Luis Lacerda Bachi Giovana Gabriela-Pereira Simone de Oliveira Freitas Amanda Cristina Araújo-Rosa Luis Vicente Franco Oliveira Claudio Ricardo Frison Wagner Luiz do Prado Raghavan Pillai Raju P Babu Balagopal Rodolfo P Vieira
author_sort	Maysa Alves Rodrigues Brandao-Rangel
title	Pulmonary function changes in older adults with and without metabolic syndrome
title_short	Pulmonary function changes in older adults with and without metabolic syndrome
title_full	Pulmonary function changes in older adults with and without metabolic syndrome
title_fullStr	Pulmonary function changes in older adults with and without metabolic syndrome
title_full_unstemmed	Pulmonary function changes in older adults with and without metabolic syndrome
title_sort	pulmonary function changes in older adults with and without metabolic syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07218e8e0d22440b811a1b9a940d50f2
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Pulmonary function changes in older adults with and without metabolic syndrome

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