Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase

Threonine is a biosynthetic precursor to dimethylpyrazine derivatives, but the pathway by which this occurs is not fully established. Here l-throenine-3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase together are shown to convert l-threonine to dimethylpyrazine derivatives as a byproduct of gly...

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Autores principales:	Tomoharu Motoyama, Shogo Nakano, Fumihito Hasebe, Ryo Miyata, Shigenori Kumazawa, Noriyuki Miyoshi, Sohei Ito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0721bf5355e34425a7e030a15af7c97f
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spelling	oai:doaj.org-article:0721bf5355e34425a7e030a15af7c97f2021-12-02T16:09:39ZChemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase10.1038/s42004-021-00545-82399-3669https://doaj.org/article/0721bf5355e34425a7e030a15af7c97f2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42004-021-00545-8https://doaj.org/toc/2399-3669Threonine is a biosynthetic precursor to dimethylpyrazine derivatives, but the pathway by which this occurs is not fully established. Here l-throenine-3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase together are shown to convert l-threonine to dimethylpyrazine derivatives as a byproduct of glycine metabolism.Tomoharu MotoyamaShogo NakanoFumihito HasebeRyo MiyataShigenori KumazawaNoriyuki MiyoshiSohei ItoNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Tomoharu Motoyama Shogo Nakano Fumihito Hasebe Ryo Miyata Shigenori Kumazawa Noriyuki Miyoshi Sohei Ito Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
description	Threonine is a biosynthetic precursor to dimethylpyrazine derivatives, but the pathway by which this occurs is not fully established. Here l-throenine-3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase together are shown to convert l-threonine to dimethylpyrazine derivatives as a byproduct of glycine metabolism.
format	article
author	Tomoharu Motoyama Shogo Nakano Fumihito Hasebe Ryo Miyata Shigenori Kumazawa Noriyuki Miyoshi Sohei Ito
author_facet	Tomoharu Motoyama Shogo Nakano Fumihito Hasebe Ryo Miyata Shigenori Kumazawa Noriyuki Miyoshi Sohei Ito
author_sort	Tomoharu Motoyama
title	Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
title_short	Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
title_full	Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
title_fullStr	Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
title_full_unstemmed	Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase
title_sort	chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by l-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate coa ligase/l-threonine aldolase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0721bf5355e34425a7e030a15af7c97f
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Chemoenzymatic synthesis of 3-ethyl-2,5-dimethylpyrazine by L-threonine 3-dehydrogenase and 2-amino-3-ketobutyrate CoA ligase/L-threonine aldolase

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