CD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process

Abstract CD31hiEmcnhi vessels were a subtype of vessels in the murine skeletal system, with high levels of platelet and endothelial cell adhesion molecule-1 (PECAM-1/CD31) and endomucin (Emcn). They were reported coupling angiogenesis and osteogenesis during bone development. We investigated the dis...

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Autores principales: Jimeng Wang, Yi Gao, Pengzhen Cheng, Donglin Li, Huijie Jiang, Chuanlei Ji, Shuaishuai Zhang, Chao Shen, Junqin Li, Yue Song, Tianqing Cao, Chunmei Wang, Liu Yang, Guoxian Pei
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/072b2720bbc444dc87b23fdcafce42e3
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spelling oai:doaj.org-article:072b2720bbc444dc87b23fdcafce42e32021-12-02T12:30:44ZCD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process10.1038/s41598-017-04150-52045-2322https://doaj.org/article/072b2720bbc444dc87b23fdcafce42e32017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04150-5https://doaj.org/toc/2045-2322Abstract CD31hiEmcnhi vessels were a subtype of vessels in the murine skeletal system, with high levels of platelet and endothelial cell adhesion molecule-1 (PECAM-1/CD31) and endomucin (Emcn). They were reported coupling angiogenesis and osteogenesis during bone development. We investigated the distribution of these vessels in rat tibiae and their temporal and spatial distribution during the bone defect repair process to improve our understanding of the importance of these vessels. We confirmed that CD31hiEmcnhi vessels were specially distributed around the trabecular bones near metaphysis and endosteum in rat tibiae. At 3 days post bone injury, CD31hiEmcnhi vessels proliferated and were extensively distributed across the entire repair area. At 7 and 14 days post-injury, these vessels decreased but were specially distributed around the growing trabecular bones near the frontier growth area, suggesting that these vessels support new bone formation. The distribution of CD31hiEmcnhi vessels and the transcriptions of Hif-1α and VEGFA, as well as BMP2 and Osterix decreased at 7 and 14 days post-injury under osteoporotic conditions, in combination with insufficient osteogenesis. Our research is of great significance to help understand the important role of CD31hiEmcnhi vessels in supporting new trabecular bones formation during bone defect repair process.Jimeng WangYi GaoPengzhen ChengDonglin LiHuijie JiangChuanlei JiShuaishuai ZhangChao ShenJunqin LiYue SongTianqing CaoChunmei WangLiu YangGuoxian PeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Jimeng Wang
Yi Gao
Pengzhen Cheng
Donglin Li
Huijie Jiang
Chuanlei Ji
Shuaishuai Zhang
Chao Shen
Junqin Li
Yue Song
Tianqing Cao
Chunmei Wang
Liu Yang
Guoxian Pei
CD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process
description Abstract CD31hiEmcnhi vessels were a subtype of vessels in the murine skeletal system, with high levels of platelet and endothelial cell adhesion molecule-1 (PECAM-1/CD31) and endomucin (Emcn). They were reported coupling angiogenesis and osteogenesis during bone development. We investigated the distribution of these vessels in rat tibiae and their temporal and spatial distribution during the bone defect repair process to improve our understanding of the importance of these vessels. We confirmed that CD31hiEmcnhi vessels were specially distributed around the trabecular bones near metaphysis and endosteum in rat tibiae. At 3 days post bone injury, CD31hiEmcnhi vessels proliferated and were extensively distributed across the entire repair area. At 7 and 14 days post-injury, these vessels decreased but were specially distributed around the growing trabecular bones near the frontier growth area, suggesting that these vessels support new bone formation. The distribution of CD31hiEmcnhi vessels and the transcriptions of Hif-1α and VEGFA, as well as BMP2 and Osterix decreased at 7 and 14 days post-injury under osteoporotic conditions, in combination with insufficient osteogenesis. Our research is of great significance to help understand the important role of CD31hiEmcnhi vessels in supporting new trabecular bones formation during bone defect repair process.
format article
author Jimeng Wang
Yi Gao
Pengzhen Cheng
Donglin Li
Huijie Jiang
Chuanlei Ji
Shuaishuai Zhang
Chao Shen
Junqin Li
Yue Song
Tianqing Cao
Chunmei Wang
Liu Yang
Guoxian Pei
author_facet Jimeng Wang
Yi Gao
Pengzhen Cheng
Donglin Li
Huijie Jiang
Chuanlei Ji
Shuaishuai Zhang
Chao Shen
Junqin Li
Yue Song
Tianqing Cao
Chunmei Wang
Liu Yang
Guoxian Pei
author_sort Jimeng Wang
title CD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process
title_short CD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process
title_full CD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process
title_fullStr CD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process
title_full_unstemmed CD31hiEmcnhi Vessels Support New Trabecular Bone Formation at the Frontier Growth Area in the Bone Defect Repair Process
title_sort cd31hiemcnhi vessels support new trabecular bone formation at the frontier growth area in the bone defect repair process
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/072b2720bbc444dc87b23fdcafce42e3
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