CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) is highly expressed in several cancers. Here the authors investigate the role of CaMKK2 expression in the tumour microenvironment and show that CaMKK2 expression in tumour-associated macrophages promotes tumour growth by suppressing T cell anti-t...

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Autores principales:	Luigi Racioppi, Erik R. Nelson, Wei Huang, Debarati Mukherjee, Scott A. Lawrence, William Lento, Anna Maria Masci, Yiquin Jiao, Sunghee Park, Brian York, Yaping Liu, Amy E. Baek, David H. Drewry, William J. Zuercher, Francesca R. Bertani, Luca Businaro, Joseph Geradts, Allison Hall, Anthony R. Means, Nelson Chao, Ching-yi Chang, Donald P. McDonnell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/072c9c0330034d37ac61bcbbffebcda1
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spelling	oai:doaj.org-article:072c9c0330034d37ac61bcbbffebcda12021-12-02T16:58:07ZCaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer10.1038/s41467-019-10424-52041-1723https://doaj.org/article/072c9c0330034d37ac61bcbbffebcda12019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10424-5https://doaj.org/toc/2041-1723Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) is highly expressed in several cancers. Here the authors investigate the role of CaMKK2 expression in the tumour microenvironment and show that CaMKK2 expression in tumour-associated macrophages promotes tumour growth by suppressing T cell anti-tumour activity.Luigi RacioppiErik R. NelsonWei HuangDebarati MukherjeeScott A. LawrenceWilliam LentoAnna Maria MasciYiquin JiaoSunghee ParkBrian YorkYaping LiuAmy E. BaekDavid H. DrewryWilliam J. ZuercherFrancesca R. BertaniLuca BusinaroJoseph GeradtsAllison HallAnthony R. MeansNelson ChaoChing-yi ChangDonald P. McDonnellNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luigi Racioppi Erik R. Nelson Wei Huang Debarati Mukherjee Scott A. Lawrence William Lento Anna Maria Masci Yiquin Jiao Sunghee Park Brian York Yaping Liu Amy E. Baek David H. Drewry William J. Zuercher Francesca R. Bertani Luca Businaro Joseph Geradts Allison Hall Anthony R. Means Nelson Chao Ching-yi Chang Donald P. McDonnell CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
description	Calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) is highly expressed in several cancers. Here the authors investigate the role of CaMKK2 expression in the tumour microenvironment and show that CaMKK2 expression in tumour-associated macrophages promotes tumour growth by suppressing T cell anti-tumour activity.
format	article
author	Luigi Racioppi Erik R. Nelson Wei Huang Debarati Mukherjee Scott A. Lawrence William Lento Anna Maria Masci Yiquin Jiao Sunghee Park Brian York Yaping Liu Amy E. Baek David H. Drewry William J. Zuercher Francesca R. Bertani Luca Businaro Joseph Geradts Allison Hall Anthony R. Means Nelson Chao Ching-yi Chang Donald P. McDonnell
author_facet	Luigi Racioppi Erik R. Nelson Wei Huang Debarati Mukherjee Scott A. Lawrence William Lento Anna Maria Masci Yiquin Jiao Sunghee Park Brian York Yaping Liu Amy E. Baek David H. Drewry William J. Zuercher Francesca R. Bertani Luca Businaro Joseph Geradts Allison Hall Anthony R. Means Nelson Chao Ching-yi Chang Donald P. McDonnell
author_sort	Luigi Racioppi
title	CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
title_short	CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
title_full	CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
title_fullStr	CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
title_full_unstemmed	CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
title_sort	camkk2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/072c9c0330034d37ac61bcbbffebcda1
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CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

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