Frontotemporal dementia and primary progressive aphasia, a review

Howard S KirshnerDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USAAbstract: Frontotemporal dementias are neurodegenerative diseases in which symptoms of frontal and/or temporal lobe disease are the first signs of the illness, and as the diseases progress, they resemb...

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Autor principal:	Kirshner HS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/072cf12f6a014a4ebc3436f278fbb4e3
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id	oai:doaj.org-article:072cf12f6a014a4ebc3436f278fbb4e3
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spelling	oai:doaj.org-article:072cf12f6a014a4ebc3436f278fbb4e32021-12-02T05:55:20ZFrontotemporal dementia and primary progressive aphasia, a review1178-2021https://doaj.org/article/072cf12f6a014a4ebc3436f278fbb4e32014-06-01T00:00:00Zhttp://www.dovepress.com/frontotemporal-dementia-and-primary-progressive-aphasia-a-review-a17182https://doaj.org/toc/1178-2021 Howard S KirshnerDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USAAbstract: Frontotemporal dementias are neurodegenerative diseases in which symptoms of frontal and/or temporal lobe disease are the first signs of the illness, and as the diseases progress, they resemble a focal left hemisphere process such as stroke or traumatic brain injury, even more than a neurodegenerative disease. Over time, some patients develop a more generalized dementia. Four clinical subtypes characterize the predominant presentations of this illness: behavioral or frontal variant FTD, progressive nonfluent aphasia, semantic dementia, and logopenic primary progressive aphasia. These clinical variants correlate with regional patterns of atrophy on brain imaging studies such as MRI and PET scanning, as well as with biochemical and molecular genetic variants of the disorder. The treatment is as yet only symptomatic, but advances in molecular genetics promise new therapies.Keywords: FTD, behavior variant or frontal variant FTD, pick's disease, PPA, progressive nonfluent aphasiaKirshner HSDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 1045-1055 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kirshner HS Frontotemporal dementia and primary progressive aphasia, a review
description	Howard S KirshnerDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USAAbstract: Frontotemporal dementias are neurodegenerative diseases in which symptoms of frontal and/or temporal lobe disease are the first signs of the illness, and as the diseases progress, they resemble a focal left hemisphere process such as stroke or traumatic brain injury, even more than a neurodegenerative disease. Over time, some patients develop a more generalized dementia. Four clinical subtypes characterize the predominant presentations of this illness: behavioral or frontal variant FTD, progressive nonfluent aphasia, semantic dementia, and logopenic primary progressive aphasia. These clinical variants correlate with regional patterns of atrophy on brain imaging studies such as MRI and PET scanning, as well as with biochemical and molecular genetic variants of the disorder. The treatment is as yet only symptomatic, but advances in molecular genetics promise new therapies.Keywords: FTD, behavior variant or frontal variant FTD, pick's disease, PPA, progressive nonfluent aphasia
format	article
author	Kirshner HS
author_facet	Kirshner HS
author_sort	Kirshner HS
title	Frontotemporal dementia and primary progressive aphasia, a review
title_short	Frontotemporal dementia and primary progressive aphasia, a review
title_full	Frontotemporal dementia and primary progressive aphasia, a review
title_fullStr	Frontotemporal dementia and primary progressive aphasia, a review
title_full_unstemmed	Frontotemporal dementia and primary progressive aphasia, a review
title_sort	frontotemporal dementia and primary progressive aphasia, a review
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/072cf12f6a014a4ebc3436f278fbb4e3
work_keys_str_mv	AT kirshnerhs frontotemporaldementiaandprimaryprogressiveaphasiaareview
_version_	1718400153428164608

Frontotemporal dementia and primary progressive aphasia, a review

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