Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models

The rising frequency of ART-conceived births is accompanied by the need for an improved understanding of the implications of ART on gametes and embryos. Increasing evidence from mouse models and human epidemiological data suggests that ART procedures may play a role in the pathophysiology of certain...

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Autores principales:	Alex Horánszky, Jessica L. Becker, Melinda Zana, Anne C. Ferguson-Smith, András Dinnyés
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	genomic imprinting imprinting disorders assisted reproductive technology DNA methylation mouse models iPSCs Genetics QH426-470
Acceso en línea:	https://doaj.org/article/073101edb9684d6f9c6ffca73a21cc5d
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spelling	oai:doaj.org-article:073101edb9684d6f9c6ffca73a21cc5d2021-11-25T17:41:00ZEpigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models10.3390/genes121117042073-4425https://doaj.org/article/073101edb9684d6f9c6ffca73a21cc5d2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1704https://doaj.org/toc/2073-4425The rising frequency of ART-conceived births is accompanied by the need for an improved understanding of the implications of ART on gametes and embryos. Increasing evidence from mouse models and human epidemiological data suggests that ART procedures may play a role in the pathophysiology of certain imprinting disorders (IDs), including Beckwith-Wiedemann syndrome, Silver-Russell syndrome, Prader-Willi syndrome, and Angelman syndrome. The underlying molecular basis of this association, however, requires further elucidation. In this review, we discuss the epigenetic and imprinting alterations of in vivo mouse models and human iPSC models of ART. Mouse models have demonstrated aberrant regulation of imprinted genes involved with ART-related IDs. In the past decade, iPSC technology has provided a platform for patient-specific cellular models of culture-associated perturbed imprinting. However, despite ongoing efforts, a deeper understanding of the susceptibility of iPSCs to epigenetic perturbation is required if they are to be reliably used for modelling ART-associated IDs. Comparing the patterns of susceptibility of imprinted genes in mouse models and IPSCs in culture improves the current understanding of the underlying mechanisms of ART-linked IDs with implications for our understanding of the influence of environmental factors such as culture and hormone treatments on epigenetically important regions of the genome such as imprints.Alex HoránszkyJessica L. BeckerMelinda ZanaAnne C. Ferguson-SmithAndrás DinnyésMDPI AGarticlegenomic imprintingimprinting disordersassisted reproductive technologyDNA methylationmouse modelsiPSCsGeneticsQH426-470ENGenes, Vol 12, Iss 1704, p 1704 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	genomic imprinting imprinting disorders assisted reproductive technology DNA methylation mouse models iPSCs Genetics QH426-470
spellingShingle	genomic imprinting imprinting disorders assisted reproductive technology DNA methylation mouse models iPSCs Genetics QH426-470 Alex Horánszky Jessica L. Becker Melinda Zana Anne C. Ferguson-Smith András Dinnyés Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models
description	The rising frequency of ART-conceived births is accompanied by the need for an improved understanding of the implications of ART on gametes and embryos. Increasing evidence from mouse models and human epidemiological data suggests that ART procedures may play a role in the pathophysiology of certain imprinting disorders (IDs), including Beckwith-Wiedemann syndrome, Silver-Russell syndrome, Prader-Willi syndrome, and Angelman syndrome. The underlying molecular basis of this association, however, requires further elucidation. In this review, we discuss the epigenetic and imprinting alterations of in vivo mouse models and human iPSC models of ART. Mouse models have demonstrated aberrant regulation of imprinted genes involved with ART-related IDs. In the past decade, iPSC technology has provided a platform for patient-specific cellular models of culture-associated perturbed imprinting. However, despite ongoing efforts, a deeper understanding of the susceptibility of iPSCs to epigenetic perturbation is required if they are to be reliably used for modelling ART-associated IDs. Comparing the patterns of susceptibility of imprinted genes in mouse models and IPSCs in culture improves the current understanding of the underlying mechanisms of ART-linked IDs with implications for our understanding of the influence of environmental factors such as culture and hormone treatments on epigenetically important regions of the genome such as imprints.
format	article
author	Alex Horánszky Jessica L. Becker Melinda Zana Anne C. Ferguson-Smith András Dinnyés
author_facet	Alex Horánszky Jessica L. Becker Melinda Zana Anne C. Ferguson-Smith András Dinnyés
author_sort	Alex Horánszky
title	Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models
title_short	Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models
title_full	Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models
title_fullStr	Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models
title_full_unstemmed	Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models
title_sort	epigenetic mechanisms of art-related imprinting disorders: lessons from ipsc and mouse models
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/073101edb9684d6f9c6ffca73a21cc5d
work_keys_str_mv	AT alexhoranszky epigeneticmechanismsofartrelatedimprintingdisorderslessonsfromipscandmousemodels AT jessicalbecker epigeneticmechanismsofartrelatedimprintingdisorderslessonsfromipscandmousemodels AT melindazana epigeneticmechanismsofartrelatedimprintingdisorderslessonsfromipscandmousemodels AT annecfergusonsmith epigeneticmechanismsofartrelatedimprintingdisorderslessonsfromipscandmousemodels AT andrasdinnyes epigeneticmechanismsofartrelatedimprintingdisorderslessonsfromipscandmousemodels
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Epigenetic Mechanisms of ART-Related Imprinting Disorders: Lessons From iPSC and Mouse Models

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