Salvianolic Acid B-Loaded Chitosan/hydroxyapatite Scaffolds Promotes The Repair Of Segmental Bone Defect By Angiogenesis And Osteogenesis
Chuanlei Ji,* Long Bi,* Jing Li, Junjun Fan Department of Orthopedics Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Li; Junjun FanDepartment of Orthopedics Surger...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2019
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| Acceso en línea: | https://doaj.org/article/0733c721d3b54d32af28cd8edd4cb463 |
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| Sumario: | Chuanlei Ji,* Long Bi,* Jing Li, Junjun Fan Department of Orthopedics Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Li; Junjun FanDepartment of Orthopedics Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, People’s Republic of ChinaEmail zyfmmu@fmmu.edu.cn; fanjunjunys@163.comBackground: Salvianolic acid B has been proven as an effective drug to promote osteogenesis and angiogenesis which could be beneficial for bone repair.Purpose: The objective of this study was to construct a salvianolic acid B-loaded chitosan/hydroxyapatite (Sal B-CS/HA) bone scaffold with controlled release and effective bioactivity.Methods: The characteristics, controlled release behavior and bioactivity of Sal B-CS/HA scaffold were evaluated in vitro. The bone repair effect was evaluated in the rabbit radius defect model.Results: The results showed that chemical and physical characteristics of salvianolic acid B and chitosan/hydroxyapatite (CS/HA) material did not obviously change after the drug loading procedure; the drug release of salvianolic acid B was stable and continuous from the Sal B-CS/HA scaffold for 8 weeks in vitro; the biocompatibility of the Sal B-CS/HA was favorable by evaluation of cell morphology and proliferation; the osteogenic and angiogenic bioactivities of the Sal B-CS/HA scaffold were proved to be effective by in vivo and in vitro tests.Conclusion: Our results suggest that this salvianolic acid B-loaded bone scaffold has potential to be used for bone defect repair with both osteogenic and angiogenic bioactivities.Keywords: angiogenesis, bone tissue engineering, controlled release, drug-loaded bone scaffold, osteogenesis, salvianolic acid B |
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