Salvianolic Acid B-Loaded Chitosan/hydroxyapatite Scaffolds Promotes The Repair Of Segmental Bone Defect By Angiogenesis And Osteogenesis

Chuanlei Ji,* Long Bi,* Jing Li, Junjun Fan Department of Orthopedics Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Li; Junjun FanDepartment of Orthopedics Surger...

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Autores principales:	Ji C, Bi L, Li J, Fan J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Angiogenesis Bone tissue engineering Controlled release Drug-loaded bone scaffold Osteogenesis Salvianolic acid B Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0733c721d3b54d32af28cd8edd4cb463
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spelling	oai:doaj.org-article:0733c721d3b54d32af28cd8edd4cb4632021-12-02T05:45:59ZSalvianolic Acid B-Loaded Chitosan/hydroxyapatite Scaffolds Promotes The Repair Of Segmental Bone Defect By Angiogenesis And Osteogenesis1178-2013https://doaj.org/article/0733c721d3b54d32af28cd8edd4cb4632019-10-01T00:00:00Zhttps://www.dovepress.com/salvianolic-acid-b-loaded-chitosanhydroxyapatite-scaffolds-promotes-th-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chuanlei Ji,* Long Bi,* Jing Li, Junjun Fan Department of Orthopedics Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Li; Junjun FanDepartment of Orthopedics Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, People’s Republic of ChinaEmail zyfmmu@fmmu.edu.cn; fanjunjunys@163.comBackground: Salvianolic acid B has been proven as an effective drug to promote osteogenesis and angiogenesis which could be beneficial for bone repair.Purpose: The objective of this study was to construct a salvianolic acid B-loaded chitosan/hydroxyapatite (Sal B-CS/HA) bone scaffold with controlled release and effective bioactivity.Methods: The characteristics, controlled release behavior and bioactivity of Sal B-CS/HA scaffold were evaluated in vitro. The bone repair effect was evaluated in the rabbit radius defect model.Results: The results showed that chemical and physical characteristics of salvianolic acid B and chitosan/hydroxyapatite (CS/HA) material did not obviously change after the drug loading procedure; the drug release of salvianolic acid B was stable and continuous from the Sal B-CS/HA scaffold for 8 weeks in vitro; the biocompatibility of the Sal B-CS/HA was favorable by evaluation of cell morphology and proliferation; the osteogenic and angiogenic bioactivities of the Sal B-CS/HA scaffold were proved to be effective by in vivo and in vitro tests.Conclusion: Our results suggest that this salvianolic acid B-loaded bone scaffold has potential to be used for bone defect repair with both osteogenic and angiogenic bioactivities.Keywords: angiogenesis, bone tissue engineering, controlled release, drug-loaded bone scaffold, osteogenesis, salvianolic acid BJi CBi LLi JFan JDove Medical PressarticleAngiogenesisBone tissue engineeringControlled releaseDrug-loaded bone scaffoldOsteogenesisSalvianolic acid BMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 8271-8284 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Angiogenesis Bone tissue engineering Controlled release Drug-loaded bone scaffold Osteogenesis Salvianolic acid B Medicine (General) R5-920
spellingShingle	Angiogenesis Bone tissue engineering Controlled release Drug-loaded bone scaffold Osteogenesis Salvianolic acid B Medicine (General) R5-920 Ji C Bi L Li J Fan J Salvianolic Acid B-Loaded Chitosan/hydroxyapatite Scaffolds Promotes The Repair Of Segmental Bone Defect By Angiogenesis And Osteogenesis
description	Chuanlei Ji,* Long Bi,* Jing Li, Junjun Fan Department of Orthopedics Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Li; Junjun FanDepartment of Orthopedics Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, People’s Republic of ChinaEmail zyfmmu@fmmu.edu.cn; fanjunjunys@163.comBackground: Salvianolic acid B has been proven as an effective drug to promote osteogenesis and angiogenesis which could be beneficial for bone repair.Purpose: The objective of this study was to construct a salvianolic acid B-loaded chitosan/hydroxyapatite (Sal B-CS/HA) bone scaffold with controlled release and effective bioactivity.Methods: The characteristics, controlled release behavior and bioactivity of Sal B-CS/HA scaffold were evaluated in vitro. The bone repair effect was evaluated in the rabbit radius defect model.Results: The results showed that chemical and physical characteristics of salvianolic acid B and chitosan/hydroxyapatite (CS/HA) material did not obviously change after the drug loading procedure; the drug release of salvianolic acid B was stable and continuous from the Sal B-CS/HA scaffold for 8 weeks in vitro; the biocompatibility of the Sal B-CS/HA was favorable by evaluation of cell morphology and proliferation; the osteogenic and angiogenic bioactivities of the Sal B-CS/HA scaffold were proved to be effective by in vivo and in vitro tests.Conclusion: Our results suggest that this salvianolic acid B-loaded bone scaffold has potential to be used for bone defect repair with both osteogenic and angiogenic bioactivities.Keywords: angiogenesis, bone tissue engineering, controlled release, drug-loaded bone scaffold, osteogenesis, salvianolic acid B
format	article
author	Ji C Bi L Li J Fan J
author_facet	Ji C Bi L Li J Fan J
author_sort	Ji C
title	Salvianolic Acid B-Loaded Chitosan/hydroxyapatite Scaffolds Promotes The Repair Of Segmental Bone Defect By Angiogenesis And Osteogenesis
title_short	Salvianolic Acid B-Loaded Chitosan/hydroxyapatite Scaffolds Promotes The Repair Of Segmental Bone Defect By Angiogenesis And Osteogenesis
title_full	Salvianolic Acid B-Loaded Chitosan/hydroxyapatite Scaffolds Promotes The Repair Of Segmental Bone Defect By Angiogenesis And Osteogenesis
title_fullStr	Salvianolic Acid B-Loaded Chitosan/hydroxyapatite Scaffolds Promotes The Repair Of Segmental Bone Defect By Angiogenesis And Osteogenesis
title_full_unstemmed	Salvianolic Acid B-Loaded Chitosan/hydroxyapatite Scaffolds Promotes The Repair Of Segmental Bone Defect By Angiogenesis And Osteogenesis
title_sort	salvianolic acid b-loaded chitosan/hydroxyapatite scaffolds promotes the repair of segmental bone defect by angiogenesis and osteogenesis
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/0733c721d3b54d32af28cd8edd4cb463
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Salvianolic Acid B-Loaded Chitosan/hydroxyapatite Scaffolds Promotes The Repair Of Segmental Bone Defect By Angiogenesis And Osteogenesis

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