Vaccination as a preventative measure contributing to immune fitness

Abstract The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect consequences may include maintenance of homeostasis through prevention of infection-induced complications; trained immunity that re-programs innate cells to respond more efficiently to later, unre...

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Autores principales:	Béatrice Laupèze, Giuseppe Del Giudice, Mark T. Doherty, Robbert Van der Most
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/07346b6c4d044d88ad114ce7ad6a5c8b
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spelling	oai:doaj.org-article:07346b6c4d044d88ad114ce7ad6a5c8b2021-12-02T16:06:33ZVaccination as a preventative measure contributing to immune fitness10.1038/s41541-021-00354-z2059-0105https://doaj.org/article/07346b6c4d044d88ad114ce7ad6a5c8b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00354-zhttps://doaj.org/toc/2059-0105Abstract The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect consequences may include maintenance of homeostasis through prevention of infection-induced complications; trained immunity that re-programs innate cells to respond more efficiently to later, unrelated threats; slowing or reversing immune senescence by altering the epigenetic clock, and leveraging the pool of memory B and T cells to improve responses to new infections. Vaccines may exploit the plasticity of the immune system to drive longer-term immune responses that promote health at a broader level than just the prevention of single, specific infections. In this perspective, we discuss the concept of “immune fitness” and how to potentially build a resilient immune system that could contribute to better health. We argue that vaccines may contribute positively to immune fitness in ways that are only beginning to be understood, and that life-course vaccination is a fundamental tool for achieving healthy aging.Béatrice LaupèzeGiuseppe Del GiudiceMark T. DohertyRobbert Van der MostNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Béatrice Laupèze Giuseppe Del Giudice Mark T. Doherty Robbert Van der Most Vaccination as a preventative measure contributing to immune fitness
description	Abstract The primary goal of vaccination is the prevention of pathogen-specific infection. The indirect consequences may include maintenance of homeostasis through prevention of infection-induced complications; trained immunity that re-programs innate cells to respond more efficiently to later, unrelated threats; slowing or reversing immune senescence by altering the epigenetic clock, and leveraging the pool of memory B and T cells to improve responses to new infections. Vaccines may exploit the plasticity of the immune system to drive longer-term immune responses that promote health at a broader level than just the prevention of single, specific infections. In this perspective, we discuss the concept of “immune fitness” and how to potentially build a resilient immune system that could contribute to better health. We argue that vaccines may contribute positively to immune fitness in ways that are only beginning to be understood, and that life-course vaccination is a fundamental tool for achieving healthy aging.
format	article
author	Béatrice Laupèze Giuseppe Del Giudice Mark T. Doherty Robbert Van der Most
author_facet	Béatrice Laupèze Giuseppe Del Giudice Mark T. Doherty Robbert Van der Most
author_sort	Béatrice Laupèze
title	Vaccination as a preventative measure contributing to immune fitness
title_short	Vaccination as a preventative measure contributing to immune fitness
title_full	Vaccination as a preventative measure contributing to immune fitness
title_fullStr	Vaccination as a preventative measure contributing to immune fitness
title_full_unstemmed	Vaccination as a preventative measure contributing to immune fitness
title_sort	vaccination as a preventative measure contributing to immune fitness
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/07346b6c4d044d88ad114ce7ad6a5c8b
work_keys_str_mv	AT beatricelaupeze vaccinationasapreventativemeasurecontributingtoimmunefitness AT giuseppedelgiudice vaccinationasapreventativemeasurecontributingtoimmunefitness AT marktdoherty vaccinationasapreventativemeasurecontributingtoimmunefitness AT robbertvandermost vaccinationasapreventativemeasurecontributingtoimmunefitness
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Vaccination as a preventative measure contributing to immune fitness

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