C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease

IFN-γ is central in inflammatory pathogenesis, response to infection and autoimmune diseases. Here the authors show that MMP12 expression is reduced in patients with SLE and that MMP12 post-translationally truncates IFN-y, inhibiting its function and affecting pathogenesis of mouse models of periton...

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Autores principales:	Antoine Dufour, Caroline L. Bellac, Ulrich Eckhard, Nestor Solis, Theo Klein, Reinhild Kappelhoff, Nikolaus Fortelny, Parker Jobin, Jacob Rozmus, Jennifer Mark, Paul Pavlidis, Vincent Dive, Sean J. Barbour, Christopher M. Overall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0735812dd0a14d5b956358f44b2c4acb
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spelling	oai:doaj.org-article:0735812dd0a14d5b956358f44b2c4acb2021-12-02T17:32:02ZC-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease10.1038/s41467-018-04717-42041-1723https://doaj.org/article/0735812dd0a14d5b956358f44b2c4acb2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04717-4https://doaj.org/toc/2041-1723IFN-γ is central in inflammatory pathogenesis, response to infection and autoimmune diseases. Here the authors show that MMP12 expression is reduced in patients with SLE and that MMP12 post-translationally truncates IFN-y, inhibiting its function and affecting pathogenesis of mouse models of peritonitis, SLE and rheumatoid arthritis.Antoine DufourCaroline L. BellacUlrich EckhardNestor SolisTheo KleinReinhild KappelhoffNikolaus FortelnyParker JobinJacob RozmusJennifer MarkPaul PavlidisVincent DiveSean J. BarbourChristopher M. OverallNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antoine Dufour Caroline L. Bellac Ulrich Eckhard Nestor Solis Theo Klein Reinhild Kappelhoff Nikolaus Fortelny Parker Jobin Jacob Rozmus Jennifer Mark Paul Pavlidis Vincent Dive Sean J. Barbour Christopher M. Overall C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease
description	IFN-γ is central in inflammatory pathogenesis, response to infection and autoimmune diseases. Here the authors show that MMP12 expression is reduced in patients with SLE and that MMP12 post-translationally truncates IFN-y, inhibiting its function and affecting pathogenesis of mouse models of peritonitis, SLE and rheumatoid arthritis.
format	article
author	Antoine Dufour Caroline L. Bellac Ulrich Eckhard Nestor Solis Theo Klein Reinhild Kappelhoff Nikolaus Fortelny Parker Jobin Jacob Rozmus Jennifer Mark Paul Pavlidis Vincent Dive Sean J. Barbour Christopher M. Overall
author_facet	Antoine Dufour Caroline L. Bellac Ulrich Eckhard Nestor Solis Theo Klein Reinhild Kappelhoff Nikolaus Fortelny Parker Jobin Jacob Rozmus Jennifer Mark Paul Pavlidis Vincent Dive Sean J. Barbour Christopher M. Overall
author_sort	Antoine Dufour
title	C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease
title_short	C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease
title_full	C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease
title_fullStr	C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease
title_full_unstemmed	C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease
title_sort	c-terminal truncation of ifn-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0735812dd0a14d5b956358f44b2c4acb
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C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease

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