The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase

The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase

Elp3 is the catalytic subunit of the eukaryotic Elongator complex that catalyzes posttranscriptional tRNA modifications. Here the authors present the crystal structures of an acetyl-CoA analog bound bacterial Elp3 and a monomeric archaeal Elp3 and show that Elp3 functions as a tRNA modification enzy...

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Autores principales: Ting-Yu Lin, Nour El Hana Abbassi, Karol Zakrzewski, Andrzej Chramiec-Głąbik, Małgorzata Jemioła-Rzemińska, Jan Różycki, Sebastian Glatt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/07373f1f587f4350adbb3cc243359271
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spelling oai:doaj.org-article:07373f1f587f4350adbb3cc2433592712021-12-02T14:39:20ZThe Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase10.1038/s41467-019-08579-22041-1723https://doaj.org/article/07373f1f587f4350adbb3cc2433592712019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08579-2https://doaj.org/toc/2041-1723Elp3 is the catalytic subunit of the eukaryotic Elongator complex that catalyzes posttranscriptional tRNA modifications. Here the authors present the crystal structures of an acetyl-CoA analog bound bacterial Elp3 and a monomeric archaeal Elp3 and show that Elp3 functions as a tRNA modification enzyme in all domains of life.Ting-Yu LinNour El Hana AbbassiKarol ZakrzewskiAndrzej Chramiec-GłąbikMałgorzata Jemioła-RzemińskaJan RóżyckiSebastian GlattNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ting-Yu Lin
Nour El Hana Abbassi
Karol Zakrzewski
Andrzej Chramiec-Głąbik
Małgorzata Jemioła-Rzemińska
Jan Różycki
Sebastian Glatt
The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase
description Elp3 is the catalytic subunit of the eukaryotic Elongator complex that catalyzes posttranscriptional tRNA modifications. Here the authors present the crystal structures of an acetyl-CoA analog bound bacterial Elp3 and a monomeric archaeal Elp3 and show that Elp3 functions as a tRNA modification enzyme in all domains of life.
format article
author Ting-Yu Lin
Nour El Hana Abbassi
Karol Zakrzewski
Andrzej Chramiec-Głąbik
Małgorzata Jemioła-Rzemińska
Jan Różycki
Sebastian Glatt
author_facet Ting-Yu Lin
Nour El Hana Abbassi
Karol Zakrzewski
Andrzej Chramiec-Głąbik
Małgorzata Jemioła-Rzemińska
Jan Różycki
Sebastian Glatt
author_sort Ting-Yu Lin
title The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase
title_short The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase
title_full The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase
title_fullStr The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase
title_full_unstemmed The Elongator subunit Elp3 is a non-canonical tRNA acetyltransferase
title_sort elongator subunit elp3 is a non-canonical trna acetyltransferase
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/07373f1f587f4350adbb3cc243359271
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AT nourelhanaabbassi theelongatorsubunitelp3isanoncanonicaltrnaacetyltransferase
AT karolzakrzewski theelongatorsubunitelp3isanoncanonicaltrnaacetyltransferase
AT andrzejchramiecgłabik theelongatorsubunitelp3isanoncanonicaltrnaacetyltransferase
AT małgorzatajemiołarzeminska theelongatorsubunitelp3isanoncanonicaltrnaacetyltransferase
AT janrozycki theelongatorsubunitelp3isanoncanonicaltrnaacetyltransferase
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