Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors

BRCA1 driven breast cancer arises from luminal progenitor cells but how BRCA1 loss-of-function affects the luminal progenitor cell state during premalignant stages of the disease is still unclear. Here, the authors demonstrate an aberrant differentiation of luminal progenitors towards a partial secr...

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Autores principales:	Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A. Lazarus, Mona Shehata, Bruno M. Simões, Alice R. Greenhalgh, Sacha J. Howell, Robert B. Clarke, Carlos Caldas, Timotheus Y. F. Halim, John C. Marioni, Walid T. Khaled
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0737eec01c874e079cadd17fce3d9856
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spelling	oai:doaj.org-article:0737eec01c874e079cadd17fce3d98562021-12-02T15:53:25ZTime-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors10.1038/s41467-021-21783-32041-1723https://doaj.org/article/0737eec01c874e079cadd17fce3d98562021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21783-3https://doaj.org/toc/2041-1723BRCA1 driven breast cancer arises from luminal progenitor cells but how BRCA1 loss-of-function affects the luminal progenitor cell state during premalignant stages of the disease is still unclear. Here, the authors demonstrate an aberrant differentiation of luminal progenitors towards a partial secretory luminal cell phenotype that occurs in a Brca1 deficient mouse model of breast cancer at early stages of tumour initiation and in breast cells from BRCA1 carriers.Karsten BachSara PensaMarija ZarocsincevaKatarzyna KaniaJulie StockisSilvain PinaudKyren A. LazarusMona ShehataBruno M. SimõesAlice R. GreenhalghSacha J. HowellRobert B. ClarkeCarlos CaldasTimotheus Y. F. HalimJohn C. MarioniWalid T. KhaledNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karsten Bach Sara Pensa Marija Zarocsinceva Katarzyna Kania Julie Stockis Silvain Pinaud Kyren A. Lazarus Mona Shehata Bruno M. Simões Alice R. Greenhalgh Sacha J. Howell Robert B. Clarke Carlos Caldas Timotheus Y. F. Halim John C. Marioni Walid T. Khaled Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
description	BRCA1 driven breast cancer arises from luminal progenitor cells but how BRCA1 loss-of-function affects the luminal progenitor cell state during premalignant stages of the disease is still unclear. Here, the authors demonstrate an aberrant differentiation of luminal progenitors towards a partial secretory luminal cell phenotype that occurs in a Brca1 deficient mouse model of breast cancer at early stages of tumour initiation and in breast cells from BRCA1 carriers.
format	article
author	Karsten Bach Sara Pensa Marija Zarocsinceva Katarzyna Kania Julie Stockis Silvain Pinaud Kyren A. Lazarus Mona Shehata Bruno M. Simões Alice R. Greenhalgh Sacha J. Howell Robert B. Clarke Carlos Caldas Timotheus Y. F. Halim John C. Marioni Walid T. Khaled
author_facet	Karsten Bach Sara Pensa Marija Zarocsinceva Katarzyna Kania Julie Stockis Silvain Pinaud Kyren A. Lazarus Mona Shehata Bruno M. Simões Alice R. Greenhalgh Sacha J. Howell Robert B. Clarke Carlos Caldas Timotheus Y. F. Halim John C. Marioni Walid T. Khaled
author_sort	Karsten Bach
title	Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
title_short	Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
title_full	Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
title_fullStr	Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
title_full_unstemmed	Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
title_sort	time-resolved single-cell analysis of brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0737eec01c874e079cadd17fce3d9856
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Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors

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