Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure.
L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a debilitating complication of therapy for Parkinson's disease (PD) that result from a progressive sensitization through repeated L-dopa exposures. The MPTP macaque model was used to study the proteome in dopamine-depleted striat...
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2008
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oai:doaj.org-article:073d7fe810194b57805c4854dc0d06d72021-11-25T06:13:25ZStriatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure.1932-620310.1371/journal.pone.0001589https://doaj.org/article/073d7fe810194b57805c4854dc0d06d72008-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18270577/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a debilitating complication of therapy for Parkinson's disease (PD) that result from a progressive sensitization through repeated L-dopa exposures. The MPTP macaque model was used to study the proteome in dopamine-depleted striatum with and without subsequent acute and chronic L-dopa treatment using two-dimensional difference in-gel electrophoresis (2D-DIGE) and mass spectrometry. The present data suggest that the dopamine-depleted striatum is so sensitive to de novo L-dopa treatment that the first ever administration alone would be able (i) to induce rapid post-translational modification-based proteomic changes that are specific to this first exposure and (ii), possibly, lead to irreversible protein level changes that would be not further modified by chronic L-dopa treatment. The apparent equivalence between first and chronic L-dopa administration suggests that priming would be the direct consequence of dopamine loss, the first L-dopa administrations only exacerbating the sensitization process but not inducing it.Birger ScholzMarcus SvenssonHenrik AlmKarl SköldMaria FälthKim KultimaCéline GuigoniEvelyne DoudnikoffQin LiAlan R CrossmanErwan BezardPer E AndrénPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 2, p e1589 (2008) |
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Medicine R Science Q Birger Scholz Marcus Svensson Henrik Alm Karl Sköld Maria Fälth Kim Kultima Céline Guigoni Evelyne Doudnikoff Qin Li Alan R Crossman Erwan Bezard Per E Andrén Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure. |
| description |
L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a debilitating complication of therapy for Parkinson's disease (PD) that result from a progressive sensitization through repeated L-dopa exposures. The MPTP macaque model was used to study the proteome in dopamine-depleted striatum with and without subsequent acute and chronic L-dopa treatment using two-dimensional difference in-gel electrophoresis (2D-DIGE) and mass spectrometry. The present data suggest that the dopamine-depleted striatum is so sensitive to de novo L-dopa treatment that the first ever administration alone would be able (i) to induce rapid post-translational modification-based proteomic changes that are specific to this first exposure and (ii), possibly, lead to irreversible protein level changes that would be not further modified by chronic L-dopa treatment. The apparent equivalence between first and chronic L-dopa administration suggests that priming would be the direct consequence of dopamine loss, the first L-dopa administrations only exacerbating the sensitization process but not inducing it. |
| format |
article |
| author |
Birger Scholz Marcus Svensson Henrik Alm Karl Sköld Maria Fälth Kim Kultima Céline Guigoni Evelyne Doudnikoff Qin Li Alan R Crossman Erwan Bezard Per E Andrén |
| author_facet |
Birger Scholz Marcus Svensson Henrik Alm Karl Sköld Maria Fälth Kim Kultima Céline Guigoni Evelyne Doudnikoff Qin Li Alan R Crossman Erwan Bezard Per E Andrén |
| author_sort |
Birger Scholz |
| title |
Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure. |
| title_short |
Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure. |
| title_full |
Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure. |
| title_fullStr |
Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure. |
| title_full_unstemmed |
Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure. |
| title_sort |
striatal proteomic analysis suggests that first l-dopa dose equates to chronic exposure. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2008 |
| url |
https://doaj.org/article/073d7fe810194b57805c4854dc0d06d7 |
| work_keys_str_mv |
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| _version_ |
1718413964189106176 |