Frequency of hepatitis B virus-DNA among hepatitis B surface-Ag negative, anti-hepatitis B core antibody-positive blood donors in Yazd, Iran

BACKGROUND: The diagnosis of hepatitis B infection in most blood transfusion centers is based on hepatitis B surface (HBs) antigen detection by an enzyme immunoassay method. This study aimed to determine the frequency of hepatitis B core (HBc) antibody, HBs antibody, and hepatitis B virus (HBV) DNA...

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Autores principales:	Mahtab Vaziri, Hayedeh Javadzadeh Shahshahani
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	anti-hepatitis b core antibody anti-hepatitis b surface antibody blood donor hepatitis b virus-dna Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/0740068b0e8e43ee80a9fbfe75c513f5
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spelling	oai:doaj.org-article:0740068b0e8e43ee80a9fbfe75c513f52021-11-12T10:08:28ZFrequency of hepatitis B virus-DNA among hepatitis B surface-Ag negative, anti-hepatitis B core antibody-positive blood donors in Yazd, Iran0973-62471998-356510.4103/ajts.AJTS_155_18https://doaj.org/article/0740068b0e8e43ee80a9fbfe75c513f52021-01-01T00:00:00Zhttp://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=179;epage=182;aulast=Vazirihttps://doaj.org/toc/0973-6247https://doaj.org/toc/1998-3565BACKGROUND: The diagnosis of hepatitis B infection in most blood transfusion centers is based on hepatitis B surface (HBs) antigen detection by an enzyme immunoassay method. This study aimed to determine the frequency of hepatitis B core (HBc) antibody, HBs antibody, and hepatitis B virus (HBV) DNA among HBs antigen-negative healthy blood donors of Yazd province, Iran.MATERIALS AND METHODS: This cross-sectional study was conducted on 1500 healthy blood donor samples negative for HBs antigen, hepatitis C virus antibody, human immunodeficiency virus antigen/antibody, and rapid plasma regain tests. All samples were screened for HBc antibody test. HBs antibody and real-time polymerase chain reaction were performed for HBc antibody-positive samples.RESULTS: HBc antibody was positive in 74 (4.9%) samples and 11 (14.9%) of 74 positive samples for HBc antibody were negative for HBs antibody. Sixty-three (85.1%) positive samples for HBc antibody had HBs antibody titer over 10 IU/L, and 43 (58.1%) had HBs antibody titer over 100 IU/L. There was no hepatitis B DNA-positive sample in the present study.CONCLUSIONS: The study results suggest that there is a very low risk for transmission of HBV through blood donors of Yazd, Iran.Mahtab VaziriHayedeh Javadzadeh ShahshahaniWolters Kluwer Medknow Publicationsarticleanti-hepatitis b core antibodyanti-hepatitis b surface antibodyblood donorhepatitis b virus-dnaDiseases of the blood and blood-forming organsRC633-647.5ENAsian Journal of Transfusion Science, Vol 15, Iss 2, Pp 179-182 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-hepatitis b core antibody anti-hepatitis b surface antibody blood donor hepatitis b virus-dna Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	anti-hepatitis b core antibody anti-hepatitis b surface antibody blood donor hepatitis b virus-dna Diseases of the blood and blood-forming organs RC633-647.5 Mahtab Vaziri Hayedeh Javadzadeh Shahshahani Frequency of hepatitis B virus-DNA among hepatitis B surface-Ag negative, anti-hepatitis B core antibody-positive blood donors in Yazd, Iran
description	BACKGROUND: The diagnosis of hepatitis B infection in most blood transfusion centers is based on hepatitis B surface (HBs) antigen detection by an enzyme immunoassay method. This study aimed to determine the frequency of hepatitis B core (HBc) antibody, HBs antibody, and hepatitis B virus (HBV) DNA among HBs antigen-negative healthy blood donors of Yazd province, Iran.MATERIALS AND METHODS: This cross-sectional study was conducted on 1500 healthy blood donor samples negative for HBs antigen, hepatitis C virus antibody, human immunodeficiency virus antigen/antibody, and rapid plasma regain tests. All samples were screened for HBc antibody test. HBs antibody and real-time polymerase chain reaction were performed for HBc antibody-positive samples.RESULTS: HBc antibody was positive in 74 (4.9%) samples and 11 (14.9%) of 74 positive samples for HBc antibody were negative for HBs antibody. Sixty-three (85.1%) positive samples for HBc antibody had HBs antibody titer over 10 IU/L, and 43 (58.1%) had HBs antibody titer over 100 IU/L. There was no hepatitis B DNA-positive sample in the present study.CONCLUSIONS: The study results suggest that there is a very low risk for transmission of HBV through blood donors of Yazd, Iran.
format	article
author	Mahtab Vaziri Hayedeh Javadzadeh Shahshahani
author_facet	Mahtab Vaziri Hayedeh Javadzadeh Shahshahani
author_sort	Mahtab Vaziri
title	Frequency of hepatitis B virus-DNA among hepatitis B surface-Ag negative, anti-hepatitis B core antibody-positive blood donors in Yazd, Iran
title_short	Frequency of hepatitis B virus-DNA among hepatitis B surface-Ag negative, anti-hepatitis B core antibody-positive blood donors in Yazd, Iran
title_full	Frequency of hepatitis B virus-DNA among hepatitis B surface-Ag negative, anti-hepatitis B core antibody-positive blood donors in Yazd, Iran
title_fullStr	Frequency of hepatitis B virus-DNA among hepatitis B surface-Ag negative, anti-hepatitis B core antibody-positive blood donors in Yazd, Iran
title_full_unstemmed	Frequency of hepatitis B virus-DNA among hepatitis B surface-Ag negative, anti-hepatitis B core antibody-positive blood donors in Yazd, Iran
title_sort	frequency of hepatitis b virus-dna among hepatitis b surface-ag negative, anti-hepatitis b core antibody-positive blood donors in yazd, iran
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/0740068b0e8e43ee80a9fbfe75c513f5
work_keys_str_mv	AT mahtabvaziri frequencyofhepatitisbvirusdnaamonghepatitisbsurfaceagnegativeantihepatitisbcoreantibodypositiveblooddonorsinyazdiran AT hayedehjavadzadehshahshahani frequencyofhepatitisbvirusdnaamonghepatitisbsurfaceagnegativeantihepatitisbcoreantibodypositiveblooddonorsinyazdiran
_version_	1718431029983707136

Frequency of hepatitis B virus-DNA among hepatitis B surface-Ag negative, anti-hepatitis B core antibody-positive blood donors in Yazd, Iran

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