A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor
Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a potential role in HBV-induced liver disease.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/0742f94d66504c4986045226266777a1 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:0742f94d66504c4986045226266777a1 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:0742f94d66504c4986045226266777a12021-12-02T15:02:55ZA genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor10.1038/s41467-020-16517-w2041-1723https://doaj.org/article/0742f94d66504c4986045226266777a12020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16517-whttps://doaj.org/toc/2041-1723Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a potential role in HBV-induced liver disease.Carla EllerLaura HeydmannChe C. ColpittsHoussein El SaghireFederica PiccioniFrank JühlingKarim MajzoubCaroline PonsCharlotte BachJulie LuciforaJoachim LupbergerMichael NassalGlenn S. CowleyNaoto FujiwaraSen-Yung HsiehYujin HoshidaEmanuele FelliPatrick PessauxCamille SureauCatherine SchusterDavid E. RootEloi R. VerrierThomas F. BaumertNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Carla Eller Laura Heydmann Che C. Colpitts Houssein El Saghire Federica Piccioni Frank Jühling Karim Majzoub Caroline Pons Charlotte Bach Julie Lucifora Joachim Lupberger Michael Nassal Glenn S. Cowley Naoto Fujiwara Sen-Yung Hsieh Yujin Hoshida Emanuele Felli Patrick Pessaux Camille Sureau Catherine Schuster David E. Root Eloi R. Verrier Thomas F. Baumert A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor |
| description |
Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a potential role in HBV-induced liver disease. |
| format |
article |
| author |
Carla Eller Laura Heydmann Che C. Colpitts Houssein El Saghire Federica Piccioni Frank Jühling Karim Majzoub Caroline Pons Charlotte Bach Julie Lucifora Joachim Lupberger Michael Nassal Glenn S. Cowley Naoto Fujiwara Sen-Yung Hsieh Yujin Hoshida Emanuele Felli Patrick Pessaux Camille Sureau Catherine Schuster David E. Root Eloi R. Verrier Thomas F. Baumert |
| author_facet |
Carla Eller Laura Heydmann Che C. Colpitts Houssein El Saghire Federica Piccioni Frank Jühling Karim Majzoub Caroline Pons Charlotte Bach Julie Lucifora Joachim Lupberger Michael Nassal Glenn S. Cowley Naoto Fujiwara Sen-Yung Hsieh Yujin Hoshida Emanuele Felli Patrick Pessaux Camille Sureau Catherine Schuster David E. Root Eloi R. Verrier Thomas F. Baumert |
| author_sort |
Carla Eller |
| title |
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor |
| title_short |
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor |
| title_full |
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor |
| title_fullStr |
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor |
| title_full_unstemmed |
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor |
| title_sort |
genome-wide gain-of-function screen identifies cdkn2c as a hbv host factor |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/0742f94d66504c4986045226266777a1 |
| work_keys_str_mv |
AT carlaeller agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT lauraheydmann agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT checcolpitts agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT housseinelsaghire agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT federicapiccioni agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT frankjuhling agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT karimmajzoub agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT carolinepons agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT charlottebach agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT julielucifora agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT joachimlupberger agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT michaelnassal agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT glennscowley agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT naotofujiwara agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT senyunghsieh agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT yujinhoshida agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT emanuelefelli agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT patrickpessaux agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT camillesureau agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT catherineschuster agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT davideroot agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT eloirverrier agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT thomasfbaumert agenomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT carlaeller genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT lauraheydmann genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT checcolpitts genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT housseinelsaghire genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT federicapiccioni genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT frankjuhling genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT karimmajzoub genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT carolinepons genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT charlottebach genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT julielucifora genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT joachimlupberger genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT michaelnassal genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT glennscowley genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT naotofujiwara genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT senyunghsieh genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT yujinhoshida genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT emanuelefelli genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT patrickpessaux genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT camillesureau genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT catherineschuster genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT davideroot genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT eloirverrier genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor AT thomasfbaumert genomewidegainoffunctionscreenidentifiescdkn2casahbvhostfactor |
| _version_ |
1718389058741207040 |