The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent

Abstract Loss of skeletal muscle mass and function occurs with increasing age. Calorie restriction (CR) increases the lifespan of C57Bl/6 mice, but not in the shorter-lived DBA/2 strain. There is some evidence that calorie restriction reduces or delays many of the age-related defects that occur in r...

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Autores principales:	Luisa Boldrin, Jacob A. Ross, Charlotte Whitmore, Bruno Doreste, Charlotte Beaver, Ayad Eddaoudi, Daniel J. Pearce, Jennifer E. Morgan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/074cae7fc6c94624a824616992ad4d08
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spelling	oai:doaj.org-article:074cae7fc6c94624a824616992ad4d082021-12-02T15:05:06ZThe effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent10.1038/s41598-017-04896-y2045-2322https://doaj.org/article/074cae7fc6c94624a824616992ad4d082017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04896-yhttps://doaj.org/toc/2045-2322Abstract Loss of skeletal muscle mass and function occurs with increasing age. Calorie restriction (CR) increases the lifespan of C57Bl/6 mice, but not in the shorter-lived DBA/2 strain. There is some evidence that calorie restriction reduces or delays many of the age-related defects that occur in rodent skeletal muscle. We therefore investigated the effect of short (2.5 month) and longer term (8.5 and 18.5 months) CR on skeletal muscle in male and female C57Bl/6 and DBA/2 mice. We found that short-term CR increased the satellite cell number and collagen VI content of muscle, but resulted in a delayed regenerative response to injury.Consistent with this, the in vitro proliferation of satellite cells derived from these muscles was reduced by CR. The percentage of stromal cells, macrophages, hematopoietic stem cells and fibroadipogenic cells in the mononucleated cell population derived from skeletal muscle was reduced by CR at various stages. But overall, these changes are neither consistent over time, nor between strain and sex. The fact that changes induced by CR do not persist with time and the dissimilarities between the two mouse strains, combined with sex differences, urge caution in applying CR to improve skeletal muscle function across the lifespan in humans.Luisa BoldrinJacob A. RossCharlotte WhitmoreBruno DoresteCharlotte BeaverAyad EddaoudiDaniel J. PearceJennifer E. MorganNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luisa Boldrin Jacob A. Ross Charlotte Whitmore Bruno Doreste Charlotte Beaver Ayad Eddaoudi Daniel J. Pearce Jennifer E. Morgan The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent
description	Abstract Loss of skeletal muscle mass and function occurs with increasing age. Calorie restriction (CR) increases the lifespan of C57Bl/6 mice, but not in the shorter-lived DBA/2 strain. There is some evidence that calorie restriction reduces or delays many of the age-related defects that occur in rodent skeletal muscle. We therefore investigated the effect of short (2.5 month) and longer term (8.5 and 18.5 months) CR on skeletal muscle in male and female C57Bl/6 and DBA/2 mice. We found that short-term CR increased the satellite cell number and collagen VI content of muscle, but resulted in a delayed regenerative response to injury.Consistent with this, the in vitro proliferation of satellite cells derived from these muscles was reduced by CR. The percentage of stromal cells, macrophages, hematopoietic stem cells and fibroadipogenic cells in the mononucleated cell population derived from skeletal muscle was reduced by CR at various stages. But overall, these changes are neither consistent over time, nor between strain and sex. The fact that changes induced by CR do not persist with time and the dissimilarities between the two mouse strains, combined with sex differences, urge caution in applying CR to improve skeletal muscle function across the lifespan in humans.
format	article
author	Luisa Boldrin Jacob A. Ross Charlotte Whitmore Bruno Doreste Charlotte Beaver Ayad Eddaoudi Daniel J. Pearce Jennifer E. Morgan
author_facet	Luisa Boldrin Jacob A. Ross Charlotte Whitmore Bruno Doreste Charlotte Beaver Ayad Eddaoudi Daniel J. Pearce Jennifer E. Morgan
author_sort	Luisa Boldrin
title	The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent
title_short	The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent
title_full	The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent
title_fullStr	The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent
title_full_unstemmed	The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent
title_sort	effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/074cae7fc6c94624a824616992ad4d08
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The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent

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