Fundamental and Clinical Applications of Materials Based on Cancer-Associated Fibroblasts in Cancers

Cancer stromal cells play a role in promoting tumor relapse and therapeutic resistance. Therefore, the current treatment paradigms for cancers are usually insufficient to eradicate cancer cells, and anti-cancer therapeutic strategies targeting stromal cells have been developed. Cancer-associated fib...

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Autores principales:	Jingtian Mu, Shengtao Gao, Jin Yang, Fanglong Wu, Hongmei Zhou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer-associated fibroblasts cancer biochip three-dimensional co-cultivation nanomaterials Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0750ba8a41a440209be110db1e019489
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spelling	oai:doaj.org-article:0750ba8a41a440209be110db1e0194892021-11-11T17:08:13ZFundamental and Clinical Applications of Materials Based on Cancer-Associated Fibroblasts in Cancers10.3390/ijms2221116711422-00671661-6596https://doaj.org/article/0750ba8a41a440209be110db1e0194892021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11671https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cancer stromal cells play a role in promoting tumor relapse and therapeutic resistance. Therefore, the current treatment paradigms for cancers are usually insufficient to eradicate cancer cells, and anti-cancer therapeutic strategies targeting stromal cells have been developed. Cancer-associated fibroblasts (CAFs) are perpetually activated fibroblasts in the tumor stroma. CAFs are the most abundant and highly heterogeneous stromal cells, and they are critically involved in cancer occurrence and progression. These effects are due to their various roles in the remodeling of the extracellular matrix, maintenance of cancer stemness, modulation of tumor metabolism, and promotion of therapy resistance. Recently, biomaterials and nanomaterials based on CAFs have been increasingly developed to perform gene or protein expression analysis, three-dimensional (3D) co-cultivation, and targeted drug delivery in cancer treatment. In this review, we systematically summarize the current research to fully understand the relevant materials and their functional diversity in CAFs, and we highlight the potential clinical applications of CAFs-oriented biomaterials and nanomaterials in anti-cancer therapy.Jingtian MuShengtao GaoJin YangFanglong WuHongmei ZhouMDPI AGarticlecancer-associated fibroblastscancerbiochipthree-dimensional co-cultivationnanomaterialsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11671, p 11671 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer-associated fibroblasts cancer biochip three-dimensional co-cultivation nanomaterials Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cancer-associated fibroblasts cancer biochip three-dimensional co-cultivation nanomaterials Biology (General) QH301-705.5 Chemistry QD1-999 Jingtian Mu Shengtao Gao Jin Yang Fanglong Wu Hongmei Zhou Fundamental and Clinical Applications of Materials Based on Cancer-Associated Fibroblasts in Cancers
description	Cancer stromal cells play a role in promoting tumor relapse and therapeutic resistance. Therefore, the current treatment paradigms for cancers are usually insufficient to eradicate cancer cells, and anti-cancer therapeutic strategies targeting stromal cells have been developed. Cancer-associated fibroblasts (CAFs) are perpetually activated fibroblasts in the tumor stroma. CAFs are the most abundant and highly heterogeneous stromal cells, and they are critically involved in cancer occurrence and progression. These effects are due to their various roles in the remodeling of the extracellular matrix, maintenance of cancer stemness, modulation of tumor metabolism, and promotion of therapy resistance. Recently, biomaterials and nanomaterials based on CAFs have been increasingly developed to perform gene or protein expression analysis, three-dimensional (3D) co-cultivation, and targeted drug delivery in cancer treatment. In this review, we systematically summarize the current research to fully understand the relevant materials and their functional diversity in CAFs, and we highlight the potential clinical applications of CAFs-oriented biomaterials and nanomaterials in anti-cancer therapy.
format	article
author	Jingtian Mu Shengtao Gao Jin Yang Fanglong Wu Hongmei Zhou
author_facet	Jingtian Mu Shengtao Gao Jin Yang Fanglong Wu Hongmei Zhou
author_sort	Jingtian Mu
title	Fundamental and Clinical Applications of Materials Based on Cancer-Associated Fibroblasts in Cancers
title_short	Fundamental and Clinical Applications of Materials Based on Cancer-Associated Fibroblasts in Cancers
title_full	Fundamental and Clinical Applications of Materials Based on Cancer-Associated Fibroblasts in Cancers
title_fullStr	Fundamental and Clinical Applications of Materials Based on Cancer-Associated Fibroblasts in Cancers
title_full_unstemmed	Fundamental and Clinical Applications of Materials Based on Cancer-Associated Fibroblasts in Cancers
title_sort	fundamental and clinical applications of materials based on cancer-associated fibroblasts in cancers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0750ba8a41a440209be110db1e019489
work_keys_str_mv	AT jingtianmu fundamentalandclinicalapplicationsofmaterialsbasedoncancerassociatedfibroblastsincancers AT shengtaogao fundamentalandclinicalapplicationsofmaterialsbasedoncancerassociatedfibroblastsincancers AT jinyang fundamentalandclinicalapplicationsofmaterialsbasedoncancerassociatedfibroblastsincancers AT fanglongwu fundamentalandclinicalapplicationsofmaterialsbasedoncancerassociatedfibroblastsincancers AT hongmeizhou fundamentalandclinicalapplicationsofmaterialsbasedoncancerassociatedfibroblastsincancers
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Fundamental and Clinical Applications of Materials Based on Cancer-Associated Fibroblasts in Cancers

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