EFFECT OF ANTI-VEGF THERAPY ON THE STRUCTURAL STATE OF THE RETINA IN DIABETIC MACULAR EDEMA

Objective: to analyze the structural state of the central area of the retina in diabetic macular edema in the background anti-VEGF therapy. Methods. The study included 38 patients (40 eyes) with diabetic macular edema. All patients received anti-VEGF-ranibizumab therapy at a dose of 0.05 ml. The res...

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Autores principales:	M. M. Bikbov, R. R. Fayzrakhmanov, R. M. Zaynullin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	diabetic macular edema macular pigment optical density ranibizumab Science Q
Acceso en línea:	https://doaj.org/article/07533e3575e4407eae46b74a18c42f37
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spelling	oai:doaj.org-article:07533e3575e4407eae46b74a18c42f372021-11-23T06:14:36ZEFFECT OF ANTI-VEGF THERAPY ON THE STRUCTURAL STATE OF THE RETINA IN DIABETIC MACULAR EDEMA2541-94202587-959610.12737/23717https://doaj.org/article/07533e3575e4407eae46b74a18c42f372016-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/314https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Objective: to analyze the structural state of the central area of the retina in diabetic macular edema in the background anti-VEGF therapy. Methods. The study included 38 patients (40 eyes) with diabetic macular edema. All patients received anti-VEGF-ranibizumab therapy at a dose of 0.05 ml. The results were analyzed after three intravitreal injections with 1 month interval. We assessed visual acuity, morphological and anatomical structure of the macular area, the sensitivity of the retina and macular pigment optical density Results. Analyzing optical density of the macular pigment we revealed a significant increase of all parameters in 73 % of patients after the therapy. The average value of the optical density before treatment was at 0.102 ± 0.01 du, on the background of anti-VEGF-therapy this figure went up to 0.213 ± 0.01 (p < 0.05). According to the optical coherence tomography average retinal thickness before treatment made 404.62 ± 15.23 ßm, after the treatment - 300.91 ± 6.43 ßm (р < 0,05). When comparing data of optical coherence tomography and macular pigment optical density we revealed more pronounced decrease in the macular pigment optical density in the area of the retinal edema and a significant increase in the basic parameters on the background of the therapy. Conclusion. Anti-VEGF-therapy significantly improves visual acuity, the recovery profile of macular edema and reduces the zone in patients with diabetic macular edema.M. M. BikbovR. R. FayzrakhmanovR. M. ZaynullinScientific Сentre for Family Health and Human Reproduction Problemsarticlediabetic macular edemamacular pigment optical densityranibizumabScienceQRUActa Biomedica Scientifica, Vol 1, Iss 6, Pp 24-27 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	diabetic macular edema macular pigment optical density ranibizumab Science Q
spellingShingle	diabetic macular edema macular pigment optical density ranibizumab Science Q M. M. Bikbov R. R. Fayzrakhmanov R. M. Zaynullin EFFECT OF ANTI-VEGF THERAPY ON THE STRUCTURAL STATE OF THE RETINA IN DIABETIC MACULAR EDEMA
description	Objective: to analyze the structural state of the central area of the retina in diabetic macular edema in the background anti-VEGF therapy. Methods. The study included 38 patients (40 eyes) with diabetic macular edema. All patients received anti-VEGF-ranibizumab therapy at a dose of 0.05 ml. The results were analyzed after three intravitreal injections with 1 month interval. We assessed visual acuity, morphological and anatomical structure of the macular area, the sensitivity of the retina and macular pigment optical density Results. Analyzing optical density of the macular pigment we revealed a significant increase of all parameters in 73 % of patients after the therapy. The average value of the optical density before treatment was at 0.102 ± 0.01 du, on the background of anti-VEGF-therapy this figure went up to 0.213 ± 0.01 (p < 0.05). According to the optical coherence tomography average retinal thickness before treatment made 404.62 ± 15.23 ßm, after the treatment - 300.91 ± 6.43 ßm (р < 0,05). When comparing data of optical coherence tomography and macular pigment optical density we revealed more pronounced decrease in the macular pigment optical density in the area of the retinal edema and a significant increase in the basic parameters on the background of the therapy. Conclusion. Anti-VEGF-therapy significantly improves visual acuity, the recovery profile of macular edema and reduces the zone in patients with diabetic macular edema.
format	article
author	M. M. Bikbov R. R. Fayzrakhmanov R. M. Zaynullin
author_facet	M. M. Bikbov R. R. Fayzrakhmanov R. M. Zaynullin
author_sort	M. M. Bikbov
title	EFFECT OF ANTI-VEGF THERAPY ON THE STRUCTURAL STATE OF THE RETINA IN DIABETIC MACULAR EDEMA
title_short	EFFECT OF ANTI-VEGF THERAPY ON THE STRUCTURAL STATE OF THE RETINA IN DIABETIC MACULAR EDEMA
title_full	EFFECT OF ANTI-VEGF THERAPY ON THE STRUCTURAL STATE OF THE RETINA IN DIABETIC MACULAR EDEMA
title_fullStr	EFFECT OF ANTI-VEGF THERAPY ON THE STRUCTURAL STATE OF THE RETINA IN DIABETIC MACULAR EDEMA
title_full_unstemmed	EFFECT OF ANTI-VEGF THERAPY ON THE STRUCTURAL STATE OF THE RETINA IN DIABETIC MACULAR EDEMA
title_sort	effect of anti-vegf therapy on the structural state of the retina in diabetic macular edema
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/07533e3575e4407eae46b74a18c42f37
work_keys_str_mv	AT mmbikbov effectofantivegftherapyonthestructuralstateoftheretinaindiabeticmacularedema AT rrfayzrakhmanov effectofantivegftherapyonthestructuralstateoftheretinaindiabeticmacularedema AT rmzaynullin effectofantivegftherapyonthestructuralstateoftheretinaindiabeticmacularedema
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EFFECT OF ANTI-VEGF THERAPY ON THE STRUCTURAL STATE OF THE RETINA IN DIABETIC MACULAR EDEMA

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