Understanding the application of stem cell therapy in cardiovascular diseases

Rakesh K Sharma, Donald J Voelker, Roma Sharma, Hanumanth K ReddyUniversity of Arkansas for Medical Sciences, Medical Center of South Arkansas, El Dorado, AR, USAAbstract: Throughout their lifetime, an individual may sustain many injuries and recover spontaneously over a period of time, without even...

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Autores principales:	Sharma RK, Voelker DJ, Sharma R, Reddy HK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/075e008a4e1945a8a4307e4d94426f80
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spelling	oai:doaj.org-article:075e008a4e1945a8a4307e4d94426f802021-12-02T00:09:57ZUnderstanding the application of stem cell therapy in cardiovascular diseases1178-6957https://doaj.org/article/075e008a4e1945a8a4307e4d94426f802012-10-01T00:00:00Zhttp://www.dovepress.com/understanding-the-application-of-stem-cell-therapy-in-cardiovascular-d-a11392https://doaj.org/toc/1178-6957Rakesh K Sharma, Donald J Voelker, Roma Sharma, Hanumanth K ReddyUniversity of Arkansas for Medical Sciences, Medical Center of South Arkansas, El Dorado, AR, USAAbstract: Throughout their lifetime, an individual may sustain many injuries and recover spontaneously over a period of time, without even realizing the injury in the first place. Wound healing occurs due to a proliferation of stem cells capable of restoring the injured tissue. The ability of adult stem cells to repair tissue is dependent upon the intrinsic ability of tissues to proliferate. The amazing capacity of embryonic stem cells to give rise to virtually any type of tissue has intensified the search for similar cell lineage in adults to treat various diseases including cardiovascular diseases. The ability to convert adult stem cells into pluripotent cells that resemble embryonic cells, and to transplant those in the desired organ for regenerative therapy is very attractive, and may offer the possibility of treating harmful disease-causing mutations. The race is on to find the best cells for treatment of cardiovascular disease. There is a need for the ideal stem cell, delivery strategies, myocardial retention, and time of administration in the ideal patient population. There are multiple modes of stem cell delivery to the heart with different cell retention rates that vary depending upon method and site of injection, such as intra coronary, intramyocardial or via coronary sinus. While there are crucial issues such as retention of stem cells, microvascular plugging, biodistribution, homing to myocardium, and various proapoptotic factors in the ischemic myocardium, the regenerative potential of stem cells offers an enormous impact on clinical applications in the management of cardiovascular diseases.Keywords: stem cell therapy, stem cell delivery, cardiovascular diseases, myocardial infarction, cardiomyopathySharma RKVoelker DJSharma RReddy HKDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2012, Iss default, Pp 29-37 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Sharma RK Voelker DJ Sharma R Reddy HK Understanding the application of stem cell therapy in cardiovascular diseases
description	Rakesh K Sharma, Donald J Voelker, Roma Sharma, Hanumanth K ReddyUniversity of Arkansas for Medical Sciences, Medical Center of South Arkansas, El Dorado, AR, USAAbstract: Throughout their lifetime, an individual may sustain many injuries and recover spontaneously over a period of time, without even realizing the injury in the first place. Wound healing occurs due to a proliferation of stem cells capable of restoring the injured tissue. The ability of adult stem cells to repair tissue is dependent upon the intrinsic ability of tissues to proliferate. The amazing capacity of embryonic stem cells to give rise to virtually any type of tissue has intensified the search for similar cell lineage in adults to treat various diseases including cardiovascular diseases. The ability to convert adult stem cells into pluripotent cells that resemble embryonic cells, and to transplant those in the desired organ for regenerative therapy is very attractive, and may offer the possibility of treating harmful disease-causing mutations. The race is on to find the best cells for treatment of cardiovascular disease. There is a need for the ideal stem cell, delivery strategies, myocardial retention, and time of administration in the ideal patient population. There are multiple modes of stem cell delivery to the heart with different cell retention rates that vary depending upon method and site of injection, such as intra coronary, intramyocardial or via coronary sinus. While there are crucial issues such as retention of stem cells, microvascular plugging, biodistribution, homing to myocardium, and various proapoptotic factors in the ischemic myocardium, the regenerative potential of stem cells offers an enormous impact on clinical applications in the management of cardiovascular diseases.Keywords: stem cell therapy, stem cell delivery, cardiovascular diseases, myocardial infarction, cardiomyopathy
format	article
author	Sharma RK Voelker DJ Sharma R Reddy HK
author_facet	Sharma RK Voelker DJ Sharma R Reddy HK
author_sort	Sharma RK
title	Understanding the application of stem cell therapy in cardiovascular diseases
title_short	Understanding the application of stem cell therapy in cardiovascular diseases
title_full	Understanding the application of stem cell therapy in cardiovascular diseases
title_fullStr	Understanding the application of stem cell therapy in cardiovascular diseases
title_full_unstemmed	Understanding the application of stem cell therapy in cardiovascular diseases
title_sort	understanding the application of stem cell therapy in cardiovascular diseases
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/075e008a4e1945a8a4307e4d94426f80
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Understanding the application of stem cell therapy in cardiovascular diseases

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