Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress

Objectives: Aluminum phosphide (AIP) is the commonly used pesticide in agriculture, which induces oxidative stress in almost all major body systems and organs. The aim of this study was to evaluate the efficacy of nanocurcumin and curcumin on serum oxidative stress level in subacute toxicity with AI...

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Autores principales:	Somayyeh Mohammadi Pasand, Akram Ranjbar, Nejat Kheiripour, Hassan Ghasemi, Hassan Rafieemehr
Formato:	article
Lenguaje:	EN
Publicado:	Hamadan University of Medical Sciences 2020
Materias:	nanocurcumin curcumin aluminum phosphide serum Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/0761954e0cde4dc793f50187d4e43a7f
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spelling	oai:doaj.org-article:0761954e0cde4dc793f50187d4e43a7f2021-11-20T10:15:41ZAntioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress10.34172/ajmb.2020.082345-4113https://doaj.org/article/0761954e0cde4dc793f50187d4e43a7f2020-12-01T00:00:00Zhttp://ajmb.umsha.ac.ir/PDF/ajmb-8-53.pdfhttps://doaj.org/toc/2345-4113Objectives: Aluminum phosphide (AIP) is the commonly used pesticide in agriculture, which induces oxidative stress in almost all major body systems and organs. The aim of this study was to evaluate the efficacy of nanocurcumin and curcumin on serum oxidative stress level in subacute toxicity with AIP. Materials and Methods: In this study 36 male Wistar rats (220-250 g) were randomly divided into six groups. Control (C) receiving normal saline; group AIPreceiving AIP (2 mg/kg daily); group Cur receiving curcumin (100 mg/kg daily); group Nano-cur receiving nanocurcumin (100 mg/kg daily); group AIP+ Cur receiving AIP (2 mg/kg daily) and curcumin (100 mg/kg daily); and group AIP and Nano-cur receiving AIP (2 mg/kg daily) and nanocurcumin (100 mg/kg daily). Serum total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), and catalase (CAT) activity were measured. Results: AIP administration led to a significant increase in LPO, and decreased the CAT activity, TAC, and TTG compared to the control group (P<0.05). Curcumin and nanocurcumin caused a significant decrease in the levels of LPO compared to the AIP-exposed groups (P<0.05). Moreover, in the nanocurcumin-treated groups, compared to a poisoned group, TAC and TTG increased significantly (P<0.01). There were no significant changes in CAT activity improvement. Conclusion: Nanocurcumin and curcumin improved the AIP-induced oxidative damage.Somayyeh Mohammadi PasandAkram RanjbarNejat KheiripourHassan GhasemiHassan RafieemehrHamadan University of Medical Sciencesarticlenanocurcumincurcuminaluminum phosphideserumMedical technologyR855-855.5ENAvicenna Journal of Medical Biochemistry, Vol 8, Iss 2, Pp 53-57 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanocurcumin curcumin aluminum phosphide serum Medical technology R855-855.5
spellingShingle	nanocurcumin curcumin aluminum phosphide serum Medical technology R855-855.5 Somayyeh Mohammadi Pasand Akram Ranjbar Nejat Kheiripour Hassan Ghasemi Hassan Rafieemehr Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress
description	Objectives: Aluminum phosphide (AIP) is the commonly used pesticide in agriculture, which induces oxidative stress in almost all major body systems and organs. The aim of this study was to evaluate the efficacy of nanocurcumin and curcumin on serum oxidative stress level in subacute toxicity with AIP. Materials and Methods: In this study 36 male Wistar rats (220-250 g) were randomly divided into six groups. Control (C) receiving normal saline; group AIPreceiving AIP (2 mg/kg daily); group Cur receiving curcumin (100 mg/kg daily); group Nano-cur receiving nanocurcumin (100 mg/kg daily); group AIP+ Cur receiving AIP (2 mg/kg daily) and curcumin (100 mg/kg daily); and group AIP and Nano-cur receiving AIP (2 mg/kg daily) and nanocurcumin (100 mg/kg daily). Serum total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), and catalase (CAT) activity were measured. Results: AIP administration led to a significant increase in LPO, and decreased the CAT activity, TAC, and TTG compared to the control group (P<0.05). Curcumin and nanocurcumin caused a significant decrease in the levels of LPO compared to the AIP-exposed groups (P<0.05). Moreover, in the nanocurcumin-treated groups, compared to a poisoned group, TAC and TTG increased significantly (P<0.01). There were no significant changes in CAT activity improvement. Conclusion: Nanocurcumin and curcumin improved the AIP-induced oxidative damage.
format	article
author	Somayyeh Mohammadi Pasand Akram Ranjbar Nejat Kheiripour Hassan Ghasemi Hassan Rafieemehr
author_facet	Somayyeh Mohammadi Pasand Akram Ranjbar Nejat Kheiripour Hassan Ghasemi Hassan Rafieemehr
author_sort	Somayyeh Mohammadi Pasand
title	Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress
title_short	Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress
title_full	Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress
title_fullStr	Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress
title_full_unstemmed	Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress
title_sort	antioxidative effects of nanocurcumin and curcumin against aluminum phosphide-induced serum oxidative stress
publisher	Hamadan University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/0761954e0cde4dc793f50187d4e43a7f
work_keys_str_mv	AT somayyehmohammadipasand antioxidativeeffectsofnanocurcuminandcurcuminagainstaluminumphosphideinducedserumoxidativestress AT akramranjbar antioxidativeeffectsofnanocurcuminandcurcuminagainstaluminumphosphideinducedserumoxidativestress AT nejatkheiripour antioxidativeeffectsofnanocurcuminandcurcuminagainstaluminumphosphideinducedserumoxidativestress AT hassanghasemi antioxidativeeffectsofnanocurcuminandcurcuminagainstaluminumphosphideinducedserumoxidativestress AT hassanrafieemehr antioxidativeeffectsofnanocurcuminandcurcuminagainstaluminumphosphideinducedserumoxidativestress
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Antioxidative Effects of Nanocurcumin and Curcumin Against Aluminum Phosphide-induced Serum Oxidative Stress

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