Alternation in Effective Connectivity With Cognitive Aging: A Longitudinal Study of Elderly Populations

In this research, we investigated the alterations in the directionality and strength of regional interactions within functionally changed brain networks and their relationship to cognitive decline during the aging process in normal elderly individuals. Thirty-seven cognitively normal elderly people...

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Autores principales:	Xingxing Cao, Tao Liu, Jiyang Jiang, Hao Liu, Jing Zhang, Nicole A. Kochan, Haijun Niu, Henry Brodaty, Perminder S. Sachdev, Wei Wen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cognitive aging fMRI effective connectivity executive function dynamic causal modeling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/0764a53fb6c147949c9cf2f4478cf903
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spelling	oai:doaj.org-article:0764a53fb6c147949c9cf2f4478cf9032021-11-12T06:30:38ZAlternation in Effective Connectivity With Cognitive Aging: A Longitudinal Study of Elderly Populations1663-436510.3389/fnagi.2021.755931https://doaj.org/article/0764a53fb6c147949c9cf2f4478cf9032021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.755931/fullhttps://doaj.org/toc/1663-4365In this research, we investigated the alterations in the directionality and strength of regional interactions within functionally changed brain networks and their relationship to cognitive decline during the aging process in normal elderly individuals. Thirty-seven cognitively normal elderly people received resting-state fMRI scans and cognitive assessments at baseline (age = 78.65 ± 3.56 years) and at 4-year follow-up. Functional connectivity analyses were used to identify networks containing brain regions whose functions changed with age as regions of interest. The spectral dynamic causal modeling (spDCM) method was used to estimate the causal interactions within networks in subjects at different time points and in subjects with different cognitive levels to explore the alterations with cognitive aging. The results showed that, at both time points, all the networks, except the frontal-parietal network (FPN) at baseline, had mutual interactions between each pair of nodes. Furthermore, when the subjects were divided with global cognition level, lost connections were only found in the subgroup with better performance. These indicated that elderly people appeared to need more interaction pathways between brain areas with cognitive decline. We also observed that the strength of the flow of information from the left angular gyrus to the precuneus, which is associated with activation of memory retrieval and the functional hub involved in various cognitive domains, was predictive of declines in executive function with the aging process, making it a potential predictor of such situation.Xingxing CaoTao LiuTao LiuJiyang JiangHao LiuJing ZhangNicole A. KochanNicole A. KochanHaijun NiuHenry BrodatyHenry BrodatyPerminder S. SachdevPerminder S. SachdevWei WenWei WenFrontiers Media S.A.articlecognitive agingfMRIeffective connectivityexecutive functiondynamic causal modelingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognitive aging fMRI effective connectivity executive function dynamic causal modeling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	cognitive aging fMRI effective connectivity executive function dynamic causal modeling Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xingxing Cao Tao Liu Tao Liu Jiyang Jiang Hao Liu Jing Zhang Nicole A. Kochan Nicole A. Kochan Haijun Niu Henry Brodaty Henry Brodaty Perminder S. Sachdev Perminder S. Sachdev Wei Wen Wei Wen Alternation in Effective Connectivity With Cognitive Aging: A Longitudinal Study of Elderly Populations
description	In this research, we investigated the alterations in the directionality and strength of regional interactions within functionally changed brain networks and their relationship to cognitive decline during the aging process in normal elderly individuals. Thirty-seven cognitively normal elderly people received resting-state fMRI scans and cognitive assessments at baseline (age = 78.65 ± 3.56 years) and at 4-year follow-up. Functional connectivity analyses were used to identify networks containing brain regions whose functions changed with age as regions of interest. The spectral dynamic causal modeling (spDCM) method was used to estimate the causal interactions within networks in subjects at different time points and in subjects with different cognitive levels to explore the alterations with cognitive aging. The results showed that, at both time points, all the networks, except the frontal-parietal network (FPN) at baseline, had mutual interactions between each pair of nodes. Furthermore, when the subjects were divided with global cognition level, lost connections were only found in the subgroup with better performance. These indicated that elderly people appeared to need more interaction pathways between brain areas with cognitive decline. We also observed that the strength of the flow of information from the left angular gyrus to the precuneus, which is associated with activation of memory retrieval and the functional hub involved in various cognitive domains, was predictive of declines in executive function with the aging process, making it a potential predictor of such situation.
format	article
author	Xingxing Cao Tao Liu Tao Liu Jiyang Jiang Hao Liu Jing Zhang Nicole A. Kochan Nicole A. Kochan Haijun Niu Henry Brodaty Henry Brodaty Perminder S. Sachdev Perminder S. Sachdev Wei Wen Wei Wen
author_facet	Xingxing Cao Tao Liu Tao Liu Jiyang Jiang Hao Liu Jing Zhang Nicole A. Kochan Nicole A. Kochan Haijun Niu Henry Brodaty Henry Brodaty Perminder S. Sachdev Perminder S. Sachdev Wei Wen Wei Wen
author_sort	Xingxing Cao
title	Alternation in Effective Connectivity With Cognitive Aging: A Longitudinal Study of Elderly Populations
title_short	Alternation in Effective Connectivity With Cognitive Aging: A Longitudinal Study of Elderly Populations
title_full	Alternation in Effective Connectivity With Cognitive Aging: A Longitudinal Study of Elderly Populations
title_fullStr	Alternation in Effective Connectivity With Cognitive Aging: A Longitudinal Study of Elderly Populations
title_full_unstemmed	Alternation in Effective Connectivity With Cognitive Aging: A Longitudinal Study of Elderly Populations
title_sort	alternation in effective connectivity with cognitive aging: a longitudinal study of elderly populations
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0764a53fb6c147949c9cf2f4478cf903
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Alternation in Effective Connectivity With Cognitive Aging: A Longitudinal Study of Elderly Populations

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